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2-Pack Facial Serum 3-O-ETHYL ASCORBIC ACID .5 g/100mL; .2 g/100mL; .005 g/100mL; .07 g/100mL Liquid, 30 mL — NDC 84148-0012-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

2-Pack Facial Serum 3-O-ETHYL ASCORBIC ACID .5 g/100mL; .2 g/100mL; .005 g/100mL; .07 g/100mL Liquid, 30 mL — NDC 84148-012-01 (Billing 84148-0012-01)

by Guangzhou Ariel Biotech Co., Ltd. · 30 mL in 1 BOTTLE

This is a package of 30 mL of 2-Pack Facial Serum 3-O-ETHYL ASCORBIC ACID .5 g/100mL; .2 g/100mL; .005 g/100mL; .07 g/100mL Liquid from Guangzhou Ariel Biotech Co., Ltd., marketed since Nov 2024 and currently FDA-listed. It is this product's only package size.

NDC 84148-0012-01
🏷️ FDA NDC (as labeled) 84148-012-01 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 84148-012-01 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
84148 labeler · 012 product · 01 package
Package marketed since
Nov 26, 2024
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 8414801201 0
FDA record last changed
Aug 27, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 84148-012-01
Product NDC 84148-012
11-digit billing NDC 84148001201
UNII 6MW60CB71P, NJ3V2F02E1, 0022LFJ74Y, M6S840WXG5
Application # M016
SPL Set ID 27c89fc6-016b-d359-e063-6394a90a5602
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-11-26
Route CUTANEOUS
Dosage form LIQUID
Substance 3-O-ETHYL ASCORBIC ACID; HYDROXYPINACOLONE RETINOATE; TARAXACUM OFFICINALE LEAF; PURSLANE
Why two NDCs? The FDA registers this code as 84148-012-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 84148-0012-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

🧪 What is this product?

This is a two-pack facial serum marketed as an over-the-counter skin care product under FDA's OTC monograph rules. The formula contains 3-O-ethyl ascorbic acid, a form of vitamin C typically used in skin products for its antioxidant and brightening properties. It also includes hydroxypinacolone retinoate, a retinoid-type ingredient commonly used in anti-aging skin formulations, along with plant extracts from purslane and dandelion leaf that are often included in skincare products for their soothing and conditioning roles.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
84148-0012-01 You're viewing this Main listing 30 mL in 1 BOTTLE 2024-11-26 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
2-Pack Facial Serum 3-O-ETHYL ASCORBIC ACID .5 g/100mL; .2 g/100mL; .005 g/100mL; .07 g/100mLthis 84148-0012-01 Guangzhou 30 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2024
On the market since
Nov 2024
📍
2026
Currently FDA-listed
2 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII TR046Y3K1G
    A liquid alcohol derived from petroleum or plant sources. It acts as a solvent and humectant in medicines, helping dissolve active ingredients and retain moisture in the formulation.
  • UNII 344S277G0Z
    Allantoin is a naturally derived compound that helps soften and soothe skin. In medicines, it works as a skin-conditioning agent and may help support wound healing and reduce irritation in topical formulations.
  • UNII 94ZLA3W45F
    Arginine is an amino acid used in medicines as a buffer and pH adjuster. It helps maintain the proper acidity level and stability of liquid formulations.
  • UNII 3XUS85K0RA
    Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
  • UNII O4M0347C6A
    C20-22 alcohols are fatty alcohols derived from natural oils or fats. They act as emulsifiers and thickeners in medicines, helping blend oil and water-based ingredients and give the product its desired texture.
  • UNII L4VKP0Y7RP
    A synthetic chemical compound derived from fatty acids with 20-22 carbon atoms, combined with phosphate. It functions as an emulsifier and surfactant to help mix oil and water-based ingredients evenly throughout the medicine.
  • UNII 8D9H4QU99H
    A synthetic fatty acid ester derived from coconut oil, used as an emulsifier and solubilizer to help mix oil and water-based ingredients and improve how the body absorbs certain drugs.
  • UNII SA6A6V432S
    Dimethyl isosorbide is a clear liquid solvent derived from natural sugar sources. It helps dissolve active ingredients and improve their absorption in liquid medicines and topical products.
  • UNII CA2Y0FE3FX
    A salt derived from licorice root extract, used as a flavoring agent and sweetener. It may also help soothe and protect mucous membranes in throat lozenges and cough products.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII H1109Z9J4N
    A natural emulsifier derived from soybean oil. It helps mix oil and water-based ingredients together, ensuring even distribution of active ingredients throughout the medicine.
  • UNII G1L3HT4CMH
    A synthetic compound used in medicines as a preservative and antimicrobial agent. It helps prevent bacterial and fungal growth, extending the product's shelf life.
  • UNII RWW266YE9I
    A buffering agent derived from piperazine chemistry. It helps maintain stable pH levels in liquid medicines, particularly in injectable or ophthalmic formulations, preventing degradation of active ingredients.
  • UNII Q7UI015FF9
    A synthetic polymer material used as a thickener and stabilizer in liquid formulations. It helps create the right texture and prevents separation of ingredients in medicines and topical products.
  • UNII 724GKU717M
    Jojoba oil is a natural liquid wax extracted from jojoba plant seeds. It's used in medicines as an emollient and lubricant to soften and smooth the product, and sometimes as a carrier or penetration enhancer.
  • UNII YSE9PPT4TH
    Hyaluronate sodium is a natural carbohydrate that holds moisture. It's used in medicines as a lubricant, thickener, and moisture-retaining agent to improve texture and delivery of the active ingredient.
  • UNII GW89575KF9
    Squalane is a lightweight oil derived from plant sources or synthesized. It acts as an emollient and lubricant in formulations, helping ingredients blend smoothly and improving product texture and spreadability.
  • UNII R0ZB2556P8
    Tocopherol is a form of vitamin E derived from plant oils. It acts as an antioxidant in medicines to prevent oils and fats from breaking down and spoiling during storage.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

20 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesPOLYACRYLATE CROSSPOLYMER-6，HYDROGENATED LECITHIN，TOCOPHEROL，C20-22 ALKYL PHOSPHATE， XANTHAN GUM，ALLANTOIN，WATER，ARGININE，C20-22 ALCOHOLS，SODIUM HYALURONATE， DIPOTASSIUM GLYCYRRHIZATE，BUTYLENE GLYCOL，GLYCERIN，COCO-CAPRYLATE/CAPRATE， DIMETHYL ISOSORBIDE，SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL，SQUALANE，1,2-HEXANEDIOL， HYDROXYACETOPHENONE，HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerGuangzhou Ariel Biotech Co., Ltd.
FDA applicationM016 (OTC MONOGRAPH DRUG)
Labeler code84148
First marketedNov 2024
Product typeHuman Otc Drug
Portfolio23 products on file

More NDCs from Guangzhou Ariel Biotech Co., Ltd. labeler code 84148

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 40 words ▾

Use After cleansing and toning, apply a small amount of serum to the face and neck, avoiding the eye area. Gently pat into the skin until fully absorbed, Use once daily in the evening for best results. Follow with moisturizer.

⏱️ Dosage and Administration 19 words ▾

Directions Because it contains retinal ingredients, sunscreen should be used in the daytime when using this essence at night

⚠️ Warnings 37 words ▾

Warnings For external use only. Avoid direct contact with eyes. Discontinue use if irritation occurs. Due to the retinol content, use sunscreen during the day when applying this serum at night. Keep out of reach of children.

📦 Storage and Handling 4 words ▾

Other information No Data

🧪 Active Ingredient 28 words ▾

Active Ingredient(s) 3-o-ETHYL ASCORBIC ACID 0.500% PORTULACA OLERACEA EXTRACT 0.070 SAURURUS CHINENSIS LEAF/ROOT EXTRACT 0.005% TARAXACUM OFFICINALE (DANDELION) LEAF EXTRACT 0.005% STEPHANIA TETRANDRA EXTRACT 0.001% HYDROXYPINACOLONE RETINOATE 0.200%

🧪 Inactive Ingredients 24 words ▾

Inactive ingredients POLYACRYLATE CROSSPOLYMER-6，HYDROGENATED LECITHIN，TOCOPHEROL，C20-22 ALKYL PHOSPHATE， XANTHAN GUM，ALLANTOIN，WATER，ARGININE，C20-22 ALCOHOLS，SODIUM HYALURONATE， DIPOTASSIUM GLYCYRRHIZATE，BUTYLENE GLYCOL，GLYCERIN，COCO-CAPRYLATE/CAPRATE， DIMETHYL ISOSORBIDE，SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL，SQUALANE，1,2-HEXANEDIOL， HYDROXYACETOPHENONE，HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

🎯 Purpose 8 words ▾

Purpose Anti aging, promotes collagen, enhances skin radiance

📄 Do Not Use 12 words ▾

Do not use If there is any irritation, please stop using immediately

📄 When Using This Product 27 words ▾

When Using Section: When using this product, avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinve use if any irritation or adverse reaction occurs.

📄 Stop Use and Ask a Doctor If 36 words ▾

For external use only. Avoid direct contact with eyes. Discontinue use if irritation occurs. Due to the retinol content, use sunscreen during the day when applying this serum at night. Keep out of reach of children.

📄 Keep Out of Reach of Children 6 words ▾

Keep out of reach of children.

📄 Package Label / Principal Display Panel 8 words ▾

Package Label - Principal Display Panel label label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Guangzhou Ariel Biotech Co., Ltd.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Guangzhou Ariel Biotech Co., Ltd. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 84148-0011-01 · Guangzhou 84148-0013-01 · Guangzhou →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.