Home › NDC Lookup › Ingredients › Niacinamide › 85977-0001-02
4 IN LOOK Ginseng Anit wrink Anti wrinkle essence NIACINAMIDE .5 g/100mL Emulsion, 50 mL — NDC 85977-0001-02 package photo

4 IN LOOK Ginseng Anit wrink Anti wrinkle essence NIACINAMIDE .5 g/100mL Emulsion, 50 mL

by Guangzhou Yanhou Cosmetics Co., Ltd. · 50 mL in 1 BOTTLE (85977-001-02)
NDC 85977-0001-02
🏷️ FDA NDC (as labeled) 85977-001-02 billing pads the product segment with a zero
This package
Contains50 mL Pack sizes4 compare ↓
Also comes in: 30 ml 85977-0001-01 100 ml 85977-0001-03 120 ml 85977-0001-04
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 85977-001-02
Product NDC 85977-001
11-digit billing NDC 85977000102
UNII 25X51I8RD4
Application # 505G(a)(3)
SPL Set ID 3b1c9d30-ebaa-217d-e063-6294a90a1ca7
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-07-30
Route TOPICAL
Dosage form EMULSION
Substance NIACINAMIDE
Why two NDCs? The FDA registers this code as 85977-001-02 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 85977-0001-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerGuangzhou Yanhou Cosmetics Co., Ltd.
FDA application505G(a)(3) (OTC MONOGRAPH DRUG)
Labeler code85977
First marketedJul 2025
Product typeHuman Otc Drug
Portfolio2 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

This is a topical emulsion containing niacinamide (vitamin B3) marketed as an anti-wrinkle essence. It is sold as an over-the-counter monograph product, meaning it is formulated under FDA's established rules for this category of skincare. Niacinamide is commonly found in anti-aging and skin-conditioning products, where it is typically used to support skin appearance and texture. The product is applied directly to the skin.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII TR046Y3K1G
    A liquid alcohol derived from petroleum or plant sources. It acts as a solvent and humectant in medicines, helping dissolve active ingredients and retain moisture in the formulation.
  • UNII L4EL31FWIL
    A synthetic peptide (short chain of amino acids) used as a conditioning or texture-enhancing agent in topical formulations. It helps improve product feel and skin compatibility in creams and lotions.
  • UNII W59H9296ZG
    A synthetic polymer made from acrylic compounds and vinylpyrrolidone. It works as a film-former and thickener in topical products, helping create a smooth texture and improve how the medication spreads on skin.
  • UNII 9PA5A687X5
    Asiatic acid is a natural compound extracted from plants that acts as an emollient and skin-conditioning agent in topical formulations. It helps soften and smooth the product's texture while supporting skin hydration.
  • UNII PKO39VY215
    A natural compound derived from Centella asiatica plant, used as an active botanical extract or skin-conditioning agent in topical formulations to support ingredient stability and product efficacy.
  • UNII 831AQW699W
    A beneficial bacterium sometimes added to medications or supplements. It may act as a probiotic ingredient intended to support digestive health, though in this product it serves as an active or functional component rather than a traditional inactive filler or binder.
  • UNII 3XUS85K0RA
    Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
  • UNII C9H2L21V7U
    A fat derived from coconut or palm oil containing shorter fatty acid chains. It serves as a solvent and carrier to help dissolve or suspend active ingredients, improving absorption and stability in liquid formulations.
  • UNII 8HO6PVN24W
    Carnosine is a naturally occurring compound made from two amino acids. In medicines, it may serve as a buffer to help maintain the product's pH stability.
  • UNII 4YS74Q4G4J
    A plant extract from Centella asiatica containing natural compounds called triterpenoids. It's used as an active ingredient in some formulations for its purported skin-supporting properties, though it functions as a botanical additive rather than a structural component of the medicine.
  • UNII BDZ3DQM98W
    Ergothioneine is a naturally occurring compound found in mushrooms and some bacteria. It's used in medicines as an antioxidant to help protect the product from degradation during storage.
  • UNII 147D247K3P
    Ethylhexylglycerin is a synthetic preservative used to prevent bacteria and mold from growing in medicines and personal care products. It helps keep the product safe and stable throughout its shelf life.
  • UNII NNE56F2N14
    A synthetic compound derived from glycerin and polyethylene glycol. It acts as an emulsifier and solubilizer to help mix water and oil-based ingredients and keep them blended throughout the product's shelf life.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 79Y1949PYO
    Gold is a precious metal used in some medications as an active therapeutic ingredient rather than a typical inactive filler. It may be included in certain formulations for its purported anti-inflammatory or immunomodulatory properties in specific medical treatments.
  • UNII H1109Z9J4N
    A natural emulsifier derived from soybean oil. It helps mix oil and water-based ingredients together, ensuring even distribution of active ingredients throughout the medicine.
  • UNII G1L3HT4CMH
    A synthetic compound used in medicines as a preservative and antimicrobial agent. It helps prevent bacterial and fungal growth, extending the product's shelf life.
  • UNII 4U3GMG1OT1
    A humectant and skin-conditioning agent derived from cellulose or similar plant sources. It helps retain moisture in the formulation and may improve texture or spreadability in topical products.
  • UNII 3B8D35Y7S4
    A weak organic acid made from natural or synthetic sources. It works as a pH buffer and preservative to maintain the medicine's stability and prevent bacterial growth during storage.
  • UNII BQX4W45LG8
    A beneficial bacterium used as a probiotic ingredient. It helps maintain the medicine's stability and viability during storage and may support the product's intended health benefits through fermentation.
  • UNII M7O1N24J82
    Madecassic acid is a natural compound extracted from Centella asiatica plant. In medications, it acts as an active pharmaceutical ingredient or functional excipient that may support skin health and wound healing in topical formulations.
  • UNII 8JC99XGU4W
    Soluble fish skin collagen is a protein derived from fish skin that acts as a binder and thickening agent in medicines. It helps hold ingredients together and gives the product the right texture or consistency.
  • UNII KK181SM5JG
    A synthetic peptide derived from amino acids. In medications and cosmetic formulations, it functions as an active conditioning agent to help maintain skin texture and firmness in topical products.
  • UNII RV743D216M
    A synthetic peptide derived from fatty acids and amino acids. It functions as a skin-conditioning agent and emollient in topical formulations, helping soften and smooth the product texture while supporting skin hydration.
  • UNII CUQ3A77YXI
    Panax ginseng root is a plant extract traditionally used in herbal preparations. In medications, it may serve as an active botanical ingredient or be included for flavoring and as a natural preservative or binder in formulations.
  • UNII WV9CM0O67Z
    Panthenol is a humectant and skin-conditioning agent derived from pantothenic acid. It's added to medicines to help retain moisture and soothe skin irritation.
  • UNII 7YC686GQ8F
    A synthetic oily substance made from castor oil. It works as a solubilizer and emulsifier to help mix oily and water-based ingredients together in the medicine.
  • UNII 7T1F30V5YH
    A synthetic emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together and keeps them from separating in liquid formulations.
  • UNII YSE9PPT4TH
    Hyaluronate sodium is a natural carbohydrate that holds moisture. It's used in medicines as a lubricant, thickener, and moisture-retaining agent to improve texture and delivery of the active ingredient.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

31 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesWATER GLYCERIN BUTYLENE GLYCOL BIFIDOBACTERIUM LONGUM GLYCERETH-26 LIMOSILACTOBACILLUS FERMENTUM ME-3 HYDROXYPROPYL TETRAHYDROPYRANTRIOL PANTHENOL ERGOTHIONEINE AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER 1,2-HEXANEDIOL SODIUM HYALURONATE CENTELLA ASIATICA TRITERPENOIDS POLYSORBATE 20 XANTHAN GUM HYDROXYACETOPHENONE PANAX GINSENG ROOT EXTRACT GOLD PEG-40 HYDROGENATED CASTOR OIL HYDROGENATED LECITHIN (SOYBEAN) ETHYLHEXYLGLYCERIN LACTIC ACID, DL- MADECASSIC ACID ASIATICOSIDE ASIATIC ACID CAPRYLIC/CAPRIC TRIGLYCERIDE CARNOSINE ACETYL HEXAPEPTIDE-8 MARINE COLLAGEN, SOLUBLE PALMITOYL PENTAPEPTIDE-4 PALMITOYL TRIPEPTIDE-1

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 30 ml 100 ml 120 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
4 IN LOOK Ginseng Anit wrink Anti wrinkle essence .5 g/100mLthis 85977-0001-02 Guangzhou 50 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2025
On the market since
Jul 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
85977-0001-01 30 mL in 1 BOTTLE (85977-001-01) 2025-07-30 Active
85977-0001-02 You're viewing this 50 mL in 1 BOTTLE (85977-001-02) 2025-07-30 Active
85977-0001-03 100 mL in 1 BOTTLE (85977-001-03) 2025-07-30 Active
85977-0001-04 120 mL in 1 BOTTLE (85977-001-04) 2025-07-30 Active

You're viewing one of 4 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 85977-0001-02?
NDC 85977-0001-02 contains 50 mL — 50 ml in 1 bottle.
What is the difference between NDC 85977-0001-02 and NDC 85977-0001-01?
Both are 4 IN LOOK Ginseng Anit wrink Anti wrinkle essence NIACINAMIDE .5 g/100mL Emulsion — the drug itself is identical. NDC 85977-0001-02 is the 50 mL package, while NDC 85977-0001-01 is the 30 ml package.
What NDC number is used to bill for this package of 4 IN LOOK Ginseng Anit wrink Anti wrinkle essence NIACINAMIDE .5 g/100mL Emulsion?
Bill NDC 85977-0001-02 — the 11-digit billing format is 85977000102. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 85977-001-02, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 85977-0001-02, written without dashes as 85977000102. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 85977-0001-02, the first segment (85977) is the labeler code FDA assigned to Guangzhou Yanhou Cosmetics Co., Ltd.; the middle segment (0001) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (02) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Guangzhou Yanhou Cosmetics Co., Ltd.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 3 other package presentations of this same product, including 30 ml (85977-0001-01), 100 ml (85977-0001-03), 120 ml (85977-0001-04). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Guangzhou Yanhou Cosmetics Co., Ltd. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 30 words ▾

Effect: with a refreshing andradiant texture,it has a delicatetouch thatiseasy toandst oothabsorb .ltreplenishesthenecessanmoistureandnutrients for the skin,improvesdryness ,wrinkles and firming.reduces fine lines,providesintensivecare,lifts and solidifiesthe skin leaving it soft,smooth.and radiant with youthfulradiance

⏱️ Dosage and Administration 30 words ▾

Usage: After cleansing and toningtake an appropriate amount of thisproduct and pour it into the palm ofyour hand to evenly apply to the face or neck .Gently massage until absorbed

⚠️ Warnings 15 words ▾

For exernal use only,Awoid contact witheyes, Discontinue use ifiritation occursStore in a cool, dry place

🧪 Active Ingredient 2 words ▾

NIACINAMIDE 0.5%

🧪 Inactive Ingredients 61 words ▾

WATER GLYCERIN BUTYLENE GLYCOL BIFIDOBACTERIUM LONGUM GLYCERETH-26 LIMOSILACTOBACILLUS FERMENTUM ME-3 HYDROXYPROPYL TETRAHYDROPYRANTRIOL PANTHENOL ERGOTHIONEINE AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER 1,2-HEXANEDIOL SODIUM HYALURONATE CENTELLA ASIATICA TRITERPENOIDS POLYSORBATE 20 XANTHAN GUM HYDROXYACETOPHENONE PANAX GINSENG ROOT EXTRACT GOLD PEG-40 HYDROGENATED CASTOR OIL HYDROGENATED LECITHIN (SOYBEAN) ETHYLHEXYLGLYCERIN LACTIC ACID, DL- MADECASSIC ACID ASIATICOSIDE ASIATIC ACID CAPRYLIC/CAPRIC TRIGLYCERIDE CARNOSINE ACETYL HEXAPEPTIDE-8 MARINE COLLAGEN, SOLUBLE PALMITOYL PENTAPEPTIDE-4 PALMITOYL TRIPEPTIDE-1

🎯 Purpose 2 words ▾

Anti winkle

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 85976-0001-01 · Galaxy 85977-0002-01 · Guangzhou →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.