J2277
J2277 – Inj, motixafortide, 0.25 mg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 2 NDCs crosswalked per 0.25 MG $26.479/unit ASP+6%
📋 J2277 summary
J2277 is a HCPCS Level II J-code used to bill motixafortide, 0.25 mg, billed per 0.25 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J2277: Aphexda
Code J2277
Billing unit 0.25 MG Payment limit $26.479/unit NDC-Crosswalk 2
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ2277
DescriptorInj, motixafortide, 0.25 mg
Billing unit0.25 MG
Payment limit / unit$26.479
Est. ASP / unit$24.980 est.
Mapped NDCs2
Data periodQ3 2026
Last updated2026-08-20
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$26.479
Est. ASP / unit
$24.980 est.
Est. after 2% sequester
$25.949
HCPCS dosage
0.25 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J2277 = 0.25 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J2277 WITH EST. MEDICARE PAY
2 NDCs map to J2277. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($26.479/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 73441-0062-01 | APHEXDA MOTIXAFORTIDE 62 mg/1.7mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Gamida | 1 VIAL, GLASS in 1 CARTON (73441-062-01)... | 62 mg/1.7mL | 248 | $6,566.79 | — | ● Active | CMS + PDAC |
| 82737-0073-01 | Aphexda Motixafortide 62 mg/1.7mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | BioLineRx | 1 VIAL, GLASS in 1 CARTON (82737-073-01)... | 62 mg/1.7mL | 248 | $6,566.79 | — | ● Active | CMS + PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$433.5K
Claims
33
Beneficiaries
30
Spend / beneficiary
$14,450.81
Spend / claim
$13,137.10
Trend by period
Where J2277 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #455 of 824
#450
AMNIOEXCEL BIODEXCEL... Q4137
$457.8K
#451
RENOGRAFT, PER SQ CM... Q4321
$456.2K
#452
ESPEROCT J7204
$454.6K
#453
ALPHANINE SD J7193
$450K
#454
CYCLOSPORINE MODIFIE... J7502
$434.7K
#455
APHEXDA J2277
$433.5K
#456
ALDURAZYME J1931
$424.1K
#457
ONCASPAR J9266
$417.8K
#458
ARISTADA J1944
$412.6K
#459
DEXAMETHASONE SODIUM... J1100
$404.4K
#460
LYUMJEV J1813
$402.9K
Total claims — #734 of 824
#729
HYCAMTIN J8705
34
#730
LAMZEDE J0217
33
#731
ZEMDRI J0291
33
#732
DOXY 100* J1271
33
#733
HALOPERIDOL LACTATE J1630
33
#734
APHEXDA J2277
33
#735
STREPTOMYCIN SULFATE J3000
32
#736
ALPHANATE J7186
32
#737
ELZONRIS J9269
32
#738
TEPADINA(J9342)* J9342
32
#739
ERZOFRI J2428
31
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $433.5K | 30 | 33 | $14,450.81 | $13,137.10 |
| 2025 (Q1-Q4) | $1.33M | 101 | 112 | $13,150.49 | $11,858.93 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📊 What bills under J2277
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Not available in current dataset
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
2 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J2277 billing FAQ
What is HCPCS code J2277?
J2277 is a HCPCS Level II J-code used to bill Inj, motixafortide, 0.25 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2277?
One unit of J2277 represents 0.25 MG. Report the number of units equal to the dose administered divided by 0.25 MG.
How many units of J2277 should I bill?
Divide the dose administered by the code's unit size (0.25 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2277?
The Medicare Part B payment limit is $26.479 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $25.949 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2277?
2 NDCs currently map to J2277 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2277 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.