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Oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray [Afrin] — RxCUI 1000992

RxNorm drug concept · Semantic branded drug
RxCUI 1000992 Semantic branded drug · SBD ● Current RxNorm concept 15 FDA products 25 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1000992
Official nameOxymetazoline hydrochloride 0.5 MG/ML Nasal Spray [Afrin]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asAfrin 0.05 % Nasal Spray; Afrin 0.5 MG/ML Nasal Spray
FDA products mapped15
Package NDCs mapped25
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Oxymetazoline Nasal Spray: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Oxymetazoline nasal spray works quickly to shrink swollen nasal membranes and relieve congestion. Each dose is meant to last 10 to 12 hours, which is why you use it no more than tw...
  • How fast does oxymetazoline nasal spray work, and how long does it last?
  • Using oxymetazoline nasal spray for more than 3 days in a row can trigger something called rebound congestion — where your nose gets stuffy again, sometimes worse than before, as s...
  • Yes, a mild burning, stinging, or sneezing sensation right after using the spray is a known side effect and is usually nothing to worry about. Some people also notice a brief incre...
📖 Read our full Oxymetazoline Nasal Spray guide →

🕸️ Concept Web — How Oxymetazoline hydrochloride 0.5 MG/ML Nasal Spra... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray [Afrin] RxCUI 1000992

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Oxymetazoline 7812
    • Oxymetazoline hydrochloride 106101
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Afrin 215051
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Oxymetazoline Nasal Spray 374488
    • Oxymetazoline hydrochloride Nasal Spray 2648224
    • Oxymetazoline Inhalant Product 1162246
    • Oxymetazoline Nasal Product 1162247
    • Oxymetazoline hydrochloride Inhalant Product 2661262
    • Oxymetazoline hydrochloride Nasal Product 2659520
    • Oxymetazoline Nasal Spray [Afrin] 361926
    • Oxymetazoline hydrochloride Nasal Spray [Afrin] 2656415
    • +5 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 14 of 19 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray SCD · 1000990
  • Oxymetazoline hydrochloride 0.5 MG/ML SCDC · 1000986
  • Oxymetazoline Nasal Spray SCDF · 374488
  • Oxymetazoline hydrochloride Nasal Spray SCDFP · 2648224
  • Oxymetazoline Inhalant Product SCDG · 1162246
  • Oxymetazoline Nasal Product SCDG · 1162247
  • Oxymetazoline hydrochloride Inhalant Product SCDGP · 2661262
  • Oxymetazoline hydrochloride Nasal Product SCDGP · 2659520

Brand-Name Concepts

  • Oxymetazoline hydrochloride 0.5 MG/ML [Afrin] SBDC · 1000991
  • Oxymetazoline Nasal Spray [Afrin] SBDF · 361926
  • Oxymetazoline hydrochloride Nasal Spray [Afrin] SBDFP · 2656415
  • Afrin Inhalant Product SBDG · 1172079
  • Afrin Nasal Product SBDG · 1172081
  • Afrin BN · 215051

📦 FDA Products & Package NDCs

15 products · 25 package NDCs
25 package NDCs map to RxCUI 1000992 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
11523-0034-01 15 mL in 1 BOTTLE (11523-0034-1) Afrin NoDrip Allergy Sinus Night Bayer HealthCare LLC. 2020-11-09
11523-0073-01 1 BOTTLE in 1 CARTON (11523-0073-1) / 15 mL in 1 BOTTLE Afrin Allergy Sinus Nasal Bayer HealthCare LLC. 2016-08-26
11523-0090-01 1 BOTTLE, PUMP in 1 CARTON (11523-0090-1) / 15 mL in 1 BOTT... Children Afrin No Drip Extra Moisturizing Stuffy Nose Pump Mist Stuffy Nose Pump Mist Bayer HealthCare LLC. 2022-07-07
11523-0090-02 2 BOTTLE, PUMP in 1 CARTON (11523-0090-2) / 15 mL in 1 BOTT... Children Afrin No Drip Extra Moisturizing Stuffy Nose Pump Mist Stuffy Nose Pump Mist Bayer HealthCare LLC. 2022-12-02
11523-0147-01 1 KIT in 1 CARTON (11523-0147-1) * 15 mL in 1 BOTTLE, SPRA... Afrin No Drip Pump Mist Bundle Pack Bayer HealthCare LLC. 2024-04-19
11523-1159-01 1 BOTTLE, PUMP in 1 CARTON (11523-1159-1) / 15 mL in 1 BOTT... Afrin Original Pump Mist Bayer HealthCare LLC. 1975-07-14
11523-1167-01 6 mL in 1 BOTTLE, SPRAY (11523-1167-1) Afrin Original Bayer HealthCare LLC. 2022-11-16
11523-1167-02 2 BOTTLE, SPRAY in 1 CARTON (11523-1167-2) / 21 mL in 1 BOT... Afrin Original Bayer HealthCare LLC. 1975-07-14
11523-1167-03 1 BOTTLE, SPRAY in 1 CARTON (11523-1167-3) / 20 mL in 1 BOT... Afrin Original Bayer HealthCare LLC. 1975-07-14
11523-1167-05 1 BOTTLE, SPRAY in 1 CARTON (11523-1167-5) / 30 mL in 1 BOT... Afrin Original Bayer HealthCare LLC. 1975-07-14
11523-1167-06 1 BOTTLE, SPRAY in 1 CARTON (11523-1167-6) / 15 mL in 1 BOT... Afrin Original Bayer HealthCare LLC. 1975-07-14
11523-1168-06 6 BOTTLE in 1 BOX (11523-1168-6) / 6 mL in 1 BOTTLE Afrin Original Nasal Bayer HealthCare LLC. 2020-10-01
11523-1350-01 1 BOTTLE, PUMP in 1 CARTON (11523-1350-1) / 15 mL in 1 BOTT... Afrin No Drip Severe Congestion Bayer HealthCare LLC 2000-08-31
11523-1350-02 2 BOTTLE, PUMP in 1 CARTON (11523-1350-2) / 20 mL in 1 BOTT... Afrin No Drip Severe Congestion Bayer HealthCare LLC 2000-08-31
11523-1350-03 2 BOTTLE, PUMP in 1 CARTON (11523-1350-3) / 15 mL in 1 BOTT... Afrin No Drip Severe Congestion Bayer HealthCare LLC 2022-12-02
11523-1350-04 3 BOTTLE, PUMP in 1 CARTON (11523-1350-4) / 20 mL in 1 BOTT... Afrin No Drip Severe Congestion Bayer HealthCare LLC 2022-12-02
11523-1783-01 1 BOTTLE, PUMP in 1 CARTON (11523-1783-1) / 15 mL in 1 BOTT... Afrin No Drip Extra Moisturizing Bayer HealthCare LLC. 2000-08-31
11523-1783-02 1 BOTTLE, PUMP in 1 CARTON (11523-1783-2) / 20 mL in 1 BOTT... Afrin No Drip Extra Moisturizing Bayer HealthCare LLC. 2000-08-31
11523-1783-03 2 BOTTLE, PUMP in 1 CARTON (11523-1783-3) / 15 mL in 1 BOTT... Afrin No Drip Extra Moisturizing Bayer HealthCare LLC. 2022-09-01
11523-3142-01 1 BOTTLE, PUMP in 1 CARTON (11523-3142-1) / 15 mL in 1 BOTT... Afrin No Drip Original Pump Mist Bayer HealthCare LLC. 1999-08-31
11523-7020-01 1 BOTTLE, SPRAY in 1 CARTON (11523-7020-1) / 15 mL in 1 BOT... Afrin Severe Congestion Bayer HealthCare LLC. 2000-08-31
50269-0017-06 6 BOTTLE in 1 BOX (50269-017-06) / 6 mL in 1 BOTTLE Afrin Original Nasal JC World Bell Wholesale Co., Inc. 2020-10-01
66715-5880-00 1 BOTTLE, SPRAY in 1 BLISTER PACK (66715-5880-0) / 6 mL in... Afrin Original Lil' Drug Store Products, Inc. 2018-02-13
66715-7016-03 1 BOTTLE, SPRAY in 1 BLISTER PACK (66715-7016-3) / 6 mL in... Afrin Original Lil' Drug Store Products, Inc. 2018-11-09
67751-0185-01 15 mL in 1 BOTTLE, SPRAY (67751-185-01) Afrin Navajo Manufacturing Company Inc. 2017-12-04
Observed labelers: Bayer HealthCare LLC. (17) · Bayer HealthCare LLC (4) · Lil' Drug Store Products, Inc. (2) · JC World Bell Wholesale Co., Inc. (1) · Navajo Manufacturing Company Inc. (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.