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Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution — RxCUI 1012377

RxNorm drug concept · Semantic clinical drug
RxCUI 1012377 Semantic clinical drug · SCD ● Current RxNorm concept 33 FDA products 45 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1012377
Official nameBupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asbupivacaine hydrochloride 0.25 % / epinephrine (as epinephrine bitartrate) 1:200,000 Injectable Solution; BUPivacaine HCl 0.25 % / EPINEPHrine 1:200,000 Injectable Solution
FDA products mapped33
Package NDCs mapped45
Reported Medicaid activity (SDUD)73,859 prescriptions · 47 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Epinephrine Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Use it at the first signs of a severe allergic reaction (anaphylaxis), such as trouble breathing, swelling, hives, vomiting or feeling faint. It is for emergencies, so don't wait t...
  • For AUVI-Q, inject into the outer thigh, through clothing if needed. Never inject it into a vein, your buttock, or your fingers, hands or feet. In young children, hold the leg firm...
  • Yes. Epinephrine is emergency treatment only, not a substitute for medical care. You need monitoring, and you may need more treatment. If symptoms don't improve, a second dose can...
  • Do I still need to go to the hospital after using it?
📖 Read our full Epinephrine Injection guide →

🕸️ Concept Web — How Bupivacaine hydrochloride 2.5 MG/ML / epinephrin... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution RxCUI 1012377

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Bupivacaine 1815
    • Epinephrine 3992
    • Bupivacaine / epinephrine 107606
    • Bupivacaine hydrochloride 267396
  2. Brand names 2

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Marcaine with Epinephrine 1372694
    • Sensorcaine with Epinephrine 219871
  3. Dose forms 12

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Bupivacaine / epinephrine Injectable Solution 374372
    • Bupivacaine hydrochloride / epinephrine Injectable Solution 2647181
    • Bupivacaine / epinephrine Injectable Product 1151351
    • Bupivacaine hydrochloride / epinephrine Injectable Product 2662588
    • Bupivacaine / epinephrine Injectable Solution [Marcaine with Epinephrine] 1012394
    • Bupivacaine / epinephrine Injectable Solution [Sensorcaine with Epinephrine] 1012416
    • Bupivacaine hydrochloride / epinephrine Injectable Solution [Marcaine with Epinephrine] 2657226
    • Bupivacaine hydrochloride / epinephrine Injectable Solution [Sensorcaine with Epinephrine] 2655129
    • +4 more in this family
  4. Clinical & branded drugs 6

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 20 of 24 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Bupivacaine hydrochloride 2.5 MG/ML SCDC · 1012376
  • Epinephrine 0.005 MG/ML SCDC · 330427
  • Bupivacaine / epinephrine Injectable Solution SCDF · 374372
  • Bupivacaine hydrochloride / epinephrine Injectable Solution SCDFP · 2647181
  • Bupivacaine / epinephrine Injectable Product SCDG · 1151351
  • Bupivacaine hydrochloride / epinephrine Injectable Product SCDGP · 2662588

Brand-Name Concepts

📦 FDA Products & Package NDCs

33 products · 45 package NDCs
45 package NDCs map to RxCUI 1012377 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00404-9828-30 1 VIAL, SINGLE-DOSE in 1 BAG (0404-9828-30) / 30 mL in 1 VI... Bupivacaine Hydrochloride and Epinephrine Henry Schein, Inc. 2022-01-09
00409-0525-25 25 VIAL, MULTI-DOSE in 1 TRAY (0409-0525-25) / 50 mL in 1 V... Marcaine Hospira, Inc. 2024-12-09
00409-1159-01 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1159-01) / 10 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2005-05-06
00409-1159-02 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1159-02) / 30 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2005-08-15
00409-1160-01 25 VIAL, MULTI-DOSE in 1 TRAY (0409-1160-01) / 50 mL in 1 V... Bupivacaine Hydrochloride Hospira, Inc. 2005-04-30
00409-1162-01 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1162-01) / 10 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2006-03-08
00409-1162-02 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1162-02) / 30 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2005-11-22
00409-1163-01 25 VIAL, MULTI-DOSE in 1 TRAY (0409-1163-01) / 50 mL in 1 V... Bupivacaine Hydrochloride Hospira, Inc. 2005-03-31
00409-1165-01 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1165-01) / 10 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2005-12-06
00409-1165-02 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1165-02) / 30 mL in 1... Bupivacaine Hydrochloride Hospira, Inc. 2005-06-08
00409-1530-25 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1530-25) / 30 mL in 1... Marcaine Hospira, Inc. 2025-08-25
00409-1541-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1541-10) / 30 mL in... Marcaine with Epinephrine Hospira, Inc. 2022-09-06
00409-1582-10 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-1582-10) / 10 mL in 1... Marcaine Hospira, Inc. 2005-07-27
00409-1582-29 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1582-29) / 30 mL in... Marcaine Hospira, Inc. 2005-08-08
00409-1587-50 1 VIAL, MULTI-DOSE in 1 CARTON (0409-1587-50) / 50 mL in 1... Marcaine Hospira, Inc. 2006-01-17
00409-1746-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1746-10) / 10 mL in... Marcaine with Epinephrine Hospira, Inc. 2005-12-09
00409-1746-30 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1746-30) / 30 mL in... Marcaine with Epinephrine Hospira, Inc. 2005-09-12
00409-1749-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1749-10) / 10 mL in... Marcaine with Epinephrine Hospira, Inc. 2005-09-22
00409-1749-29 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1749-29) / 30 mL in... Marcaine with Epinephrine Hospira, Inc. 2005-09-12
00409-1752-50 1 VIAL, MULTI-DOSE in 1 CARTON (0409-1752-50) / 50 mL in 1... Marcaine with Epinephrine Hospira, Inc. 2006-02-06
00409-1755-50 1 VIAL, MULTI-DOSE in 1 CARTON (0409-1755-50) / 50 mL in 1... Marcaine with Epinephrine Hospira, Inc. 2006-03-22
00409-2253-25 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2253-25) / 30 mL in 1... Marcaine Hospira, Inc. 2025-04-14
00409-2510-25 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2510-25) / 10 mL in 1... Marcaine Hospira, Inc. 2025-08-28
00409-3812-01 1 VIAL, MULTI-DOSE in 1 CARTON (0409-3812-01) / 50 mL in 1... Marcaine with Epinephrine Hospira, Inc. 2022-09-06
00409-4208-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-4208-10) / 30 mL in... Marcaine with Epinephrine Hospira, Inc. 2022-09-26
00409-5010-25 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-5010-25) / 10 mL in 1... Marcaine Hospira, Inc. 2025-02-03
00409-5738-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-5738-10) / 10 mL in... Marcaine with Epinephrine Hospira, Inc. 2022-09-06
00409-6581-01 1 VIAL, MULTI-DOSE in 1 CARTON (0409-6581-01) / 50 mL in 1... Marcaine with Epinephrine Hospira, Inc. 2022-09-26
00409-7535-25 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-7535-25) / 30 mL in 1... Marcaine Hospira, Inc. 2025-05-27
00409-8126-10 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-8126-10) / 10 mL in... Marcaine with Epinephrine Hospira, Inc. 2022-09-06
00409-9042-01 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-9042-01) / 10 mL in... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2005-08-26
00409-9042-17 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-9042-17) / 30 mL in 1... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2011-03-21
00409-9043-01 25 CARTON in 1 BOX (0409-9043-01) / 1 VIAL, MULTI-DOSE in 1... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2005-11-29
00409-9045-01 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-9045-01) / 10 mL in... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2005-09-08
00409-9045-17 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-9045-17) / 30 mL in 1... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2011-03-21
00409-9046-01 25 CARTON in 1 BOX (0409-9046-01) / 1 VIAL, MULTI-DOSE in 1... Bupivacaine Hydrochloride and Epinephrine Hospira, Inc. 2005-07-26
51662-1397-01 50 mL in 1 VIAL, MULTI-DOSE (51662-1397-1) SENSORCAINE(R) (BUPIVACAINE HCI AND EPINEPHRINE) HF Acquisition Co LLC, DBA HealthFirst 2019-10-08
51662-1397-02 1 VIAL, MULTI-DOSE in 1 POUCH (51662-1397-2) / 50 mL in 1 V... SENSORCAINE(R) (BUPIVACAINE HCI AND EPINEPHRINE) HF Acquisition Co LLC, DBA HealthFirst 2021-01-26
51662-1397-03 25 POUCH in 1 CASE (51662-1397-3) / 1 VIAL, MULTI-DOSE in 1... SENSORCAINE(R) (BUPIVACAINE HCI AND EPINEPHRINE) HF Acquisition Co LLC, DBA HealthFirst 2021-01-26
63323-0461-57 25 VIAL, MULTI-DOSE in 1 TRAY (63323-461-57) / 50 mL in 1 V... SENSORCAINE Fresenius Kabi USA, LLC 2010-11-19
63323-0463-57 25 VIAL, MULTI-DOSE in 1 TRAY (63323-463-57) / 50 mL in 1 V... SENSORCAINE Fresenius Kabi USA, LLC 2010-11-19
63323-0468-17 25 VIAL, SINGLE-DOSE in 1 TRAY (63323-468-17) / 10 mL in 1... SENSORCAINE MPF Fresenius Kabi USA, LLC 2010-11-19
63323-0468-37 25 VIAL, SINGLE-DOSE in 1 TRAY (63323-468-37) / 30 mL in 1... SENSORCAINE MPF Fresenius Kabi USA, LLC 2010-11-19
63323-0472-17 25 VIAL, SINGLE-DOSE in 1 TRAY (63323-472-17) / 10 mL in 1... SENSORCAINE MPF Fresenius Kabi USA, LLC 2010-11-19
63323-0472-37 25 VIAL, SINGLE-DOSE in 1 TRAY (63323-472-37) / 30 mL in 1... SENSORCAINE MPF Fresenius Kabi USA, LLC 2010-11-19
Observed labelers: Hospira, Inc. (35) · Fresenius Kabi USA, LLC (6) · HF Acquisition Co LLC, DBA HealthFirst (3) · Henry Schein, Inc. (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🧾 Billing Codes (HCPCS)

Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.
CodeDescriptorMapped packagesSources
J0665 Inj, bupivacaine, nos, 0.5mg 19 CMS
⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.