Home › NDC Lookup › RxCUI directory › RxCUI 1012381

Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution [Marcain... — RxCUI 1012381

Name: Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution [Ma… (RxCUI 1012381)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic branded drug

RxCUI 1012381 Semantic branded drug · SBD ● Current RxNorm concept 18 FDA products 21 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1012381

Official nameBupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution [Marcaine with Epinephrine]

Concept typeSemantic branded drug (SBD)

RxNorm statusCurrent RxNorm concept

Also known asMarcaine 0.25 % / epinephrine 1:200,000 Injectable Solution; Marcaine with Epinephrine 0.25/1:200000 (bupivacaine hydrochloride / epinephrine (as bitartrate) ) Injectable Solution

FDA products mapped18

Package NDCs mapped21

Reported Medicaid activity (SDUD)6,725 prescriptions · 25 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Epinephrine Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Use it at the first signs of a severe allergic reaction (anaphylaxis), such as trouble breathing, swelling, hives, vomiting or feeling faint. It is for emergencies, so don't wait t...
For AUVI-Q, inject into the outer thigh, through clothing if needed. Never inject it into a vein, your buttock, or your fingers, hands or feet. In young children, hold the leg firm...
Yes. Epinephrine is emergency treatment only, not a substitute for medical care. You need monitoring, and you may need more treatment. If symptoms don't improve, a second dose can...
Do I still need to go to the hospital after using it?

📖 Read our full Epinephrine Injection guide →

🕸️ Concept Web — How Bupivacaine hydrochloride 2.5 MG/ML / epinephrin... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution [Marcaine with Epinephrine] RxCUI 1012381 Semantic branded drug · SBD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 4

The active substance itself — no strength, form, or brand attached yet.
- Bupivacaine 1815 IN
- Epinephrine 3992 IN
- Bupivacaine / epinephrine 107606 MIN
- Bupivacaine hydrochloride 267396 PIN
Brand names 1

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Marcaine with Epinephrine 1372694 BN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Bupivacaine / epinephrine Injectable Solution 374372 SCDF
- Bupivacaine hydrochloride / epinephrine Injectable Solution 2647181 SCDFP
- Bupivacaine / epinephrine Injectable Product 1151351 SCDG
- Bupivacaine hydrochloride / epinephrine Injectable Product 2662588 SCDGP
- Bupivacaine / epinephrine Injectable Solution [Marcaine with Epinephrine] 1012394 SBDF
- Bupivacaine hydrochloride / epinephrine Injectable Solution [Marcaine with Epinephrine] 2657226 SBDFP
- Marcaine with Epinephrine Injectable Product 1180419 SBDG
- Injectable Solution 316949 DF
- +1 more in this family
Clinical & branded drugs 4

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution 1012377 SCD
- Bupivacaine hydrochloride 2.5 MG/ML 1012376 SCDC
- Epinephrine 0.005 MG/ML 330427 SCDC
- Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML [Marcaine with Epinephrine] 1012379 SBDC

Showing up to 8 concepts per family — 17 of 18 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution SCD · 1012377
Bupivacaine hydrochloride 2.5 MG/ML SCDC · 1012376
Epinephrine 0.005 MG/ML SCDC · 330427
Bupivacaine / epinephrine Injectable Solution SCDF · 374372
Bupivacaine hydrochloride / epinephrine Injectable Solution SCDFP · 2647181
Bupivacaine / epinephrine Injectable Product SCDG · 1151351
Bupivacaine hydrochloride / epinephrine Injectable Product SCDGP · 2662588

Brand-Name Concepts

Bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML [Marcaine with Epinephrine] SBDC · 1012379
Bupivacaine / epinephrine Injectable Solution [Marcaine with Epinephrine] SBDF · 1012394
Bupivacaine hydrochloride / epinephrine Injectable Solution [Marcaine with Epinephrine] SBDFP · 2657226
Marcaine with Epinephrine Injectable Product SBDG · 1180419
Marcaine with Epinephrine BN · 1372694

📦 FDA Products & Package NDCs

18 products · 21 package NDCs

21 package NDCs map to RxCUI 1012381 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00409-0525-25	25 VIAL, MULTI-DOSE in 1 TRAY (0409-0525-25) / 50 mL in 1 V...	Marcaine	Hospira, Inc.	2024-12-09
00409-1530-25	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-1530-25) / 30 mL in 1...	Marcaine	Hospira, Inc.	2025-08-25
00409-1541-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1541-10) / 30 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-06
00409-1582-10	10 VIAL, SINGLE-DOSE in 1 TRAY (0409-1582-10) / 10 mL in 1...	Marcaine	Hospira, Inc.	2005-07-27
00409-1582-29	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1582-29) / 30 mL in...	Marcaine	Hospira, Inc.	2005-08-08
00409-1587-50	1 VIAL, MULTI-DOSE in 1 CARTON (0409-1587-50) / 50 mL in 1...	Marcaine	Hospira, Inc.	2006-01-17
00409-1746-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1746-10) / 10 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2005-12-09
00409-1746-30	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1746-30) / 30 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2005-09-12
00409-1749-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1749-10) / 10 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2005-09-22
00409-1749-29	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-1749-29) / 30 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2005-09-12
00409-1752-50	1 VIAL, MULTI-DOSE in 1 CARTON (0409-1752-50) / 50 mL in 1...	Marcaine with Epinephrine	Hospira, Inc.	2006-02-06
00409-1755-50	1 VIAL, MULTI-DOSE in 1 CARTON (0409-1755-50) / 50 mL in 1...	Marcaine with Epinephrine	Hospira, Inc.	2006-03-22
00409-2253-25	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2253-25) / 30 mL in 1...	Marcaine	Hospira, Inc.	2025-04-14
00409-2510-25	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2510-25) / 10 mL in 1...	Marcaine	Hospira, Inc.	2025-08-28
00409-3812-01	1 VIAL, MULTI-DOSE in 1 CARTON (0409-3812-01) / 50 mL in 1...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-06
00409-4208-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-4208-10) / 30 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-26
00409-5010-25	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-5010-25) / 10 mL in 1...	Marcaine	Hospira, Inc.	2025-02-03
00409-5738-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-5738-10) / 10 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-06
00409-6581-01	1 VIAL, MULTI-DOSE in 1 CARTON (0409-6581-01) / 50 mL in 1...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-26
00409-7535-25	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-7535-25) / 30 mL in 1...	Marcaine	Hospira, Inc.	2025-05-27
00409-8126-10	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-8126-10) / 10 mL in...	Marcaine with Epinephrine	Hospira, Inc.	2022-09-06

Observed labelers: Hospira, Inc. (21) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🧾 Billing Codes (HCPCS)

Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.

Code	Descriptor	Mapped packages	Sources
J0665	Inj, bupivacaine, nos, 0.5mg	9	CMS

⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.