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Acetaminophen 325 MG / phenylephrine hydrochloride 5 MG Oral Tablet — RxCUI 1046378

RxNorm drug concept · Semantic clinical drug
RxCUI 1046378 Semantic clinical drug · SCD ● Current RxNorm concept 50 FDA products 55 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1046378
Official nameAcetaminophen 325 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / phenylephrine hydrochloride 5 MG Oral Tablet; acetaminophen 325 MG / phenylephrine HCl 5 MG Oral Tablet
FDA products mapped50
Package NDCs mapped55
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It depends on the product. The injection raises low blood pressure during anesthesia and, for some products, septic shock. Eye drops dilate the pupil, nasal products relieve conges...
  • Be careful. Over-the-counter phenylephrine should not be used with a prescription MAOI or within 2 weeks of stopping one. If you aren't sure whether your medicine is an MAOI, ask m...
  • With the injection, the most common are nausea, vomiting and headache. Call for help right away if you have chest pain, a very slow heartbeat, or pain or skin changes around the IV...
  • Stop and talk to a doctor if you get nervousness, dizziness or sleeplessness. Also stop if symptoms last more than 7 days or come with a fever. Don't use more than the label recomm...
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 325 MG / phenylephrine hydrochlori... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / phenylephrine hydrochloride 5 MG Oral Tablet RxCUI 1046378

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Phenylephrine 8163
    • Acetaminophen / phenylephrine 214186
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / phenylephrine Oral Tablet 373379
    • Acetaminophen / phenylephrine hydrochloride Oral Tablet 2649220
    • Acetaminophen / phenylephrine Oral Product 1151913
    • Acetaminophen / phenylephrine Pill 1151914
    • Acetaminophen / phenylephrine hydrochloride Oral Product 2663092
    • Acetaminophen / phenylephrine hydrochloride Pill 2662558
    • Oral Tablet 317541
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 2

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

50 products · 55 package NDCs
55 package NDCs map to RxCUI 1046378 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00135-0607-02 3 BLISTER PACK in 1 CARTON (0135-0607-02) / 8 TABLET, FILM... Panadol Cold and Flu NonDrowsy Haleon US Holdings LLC 2017-06-01
00135-0607-03 50 PACKET in 1 CARTON (0135-0607-03) / 2 TABLET, FILM COATE... Panadol Cold and Flu NonDrowsy Haleon US Holdings LLC 2017-06-01
00135-7031-01 50 PACKET in 1 CARTON (0135-7031-01) / 2 TABLET, FILM COATE... Panadol Cold and Flu NonDrowsy Haleon US Holdings LLC 2022-12-20
00135-7031-02 24 TABLET, FILM COATED in 1 BLISTER PACK (0135-7031-02) Panadol Cold and Flu NonDrowsy Haleon US Holdings LLC 2022-12-20
00363-4066-08 2 BLISTER PACK in 1 CARTON (0363-4066-08) / 12 TABLET, FILM... Sinus and Headache Walgreen Company 2005-07-26
11822-5022-08 2 BLISTER PACK in 1 CARTON (11822-5022-8) / 12 TABLET in 1... Sinus Pressure and Pain PE Maximum Strength Rite Aid Corporation 2005-06-23
21130-0466-08 2 BLISTER PACK in 1 CARTON (21130-466-08) / 12 TABLET, FILM... Pain Relief Non Drowsy Daytime Better Living Brands, LLC 2005-07-26
21130-0474-08 2 BLISTER PACK in 1 CARTON (21130-474-08) / 12 TABLET, FILM... Pain Relief Sinus Congestion Better Living Brands, LLC 2024-06-28
21130-0502-21 2 BLISTER PACK in 1 CARTON (21130-502-21) / 12 TABLET in 1... Sinus Relief MAXIMUM STRENGTH Better Living Brands, LLC 2005-06-23
30142-0466-08 2 BLISTER PACK in 1 CARTON (30142-466-08) / 12 TABLET, FILM... Sinus Plus Headache Kroger Company 2021-05-11
36800-0320-06 2 BLISTER PACK in 1 CARTON (36800-320-06) / 12 TABLET, COAT... Sinus Pressure plus Pain PE TOPCO ASSOCIATES LLC 2021-06-18
36800-0322-05 2 BLISTER PACK in 1 CARTON (36800-322-05) / 12 TABLET, COAT... Sinus plus Headache TOPCARE 2020-07-01
37808-0466-08 2 BLISTER PACK in 1 CARTON (37808-466-08) / 12 TABLET, FILM... Sinus Congestion and Pain Daytime Non-Drowsy H E B 2005-07-26
41163-0664-08 2 BLISTER PACK in 1 CARTON (41163-664-08) / 12 TABLET, FILM... Sinus Congestion and Pain Daytime United Natural Foods, Inc. dba UNFI 2005-07-26
42507-0223-05 2 BLISTER PACK in 1 CARTON (42507-223-05) / 12 TABLET, COAT... Sinus and Headache HYVEE INC 2025-10-22
42507-0320-06 2 BLISTER PACK in 1 CARTON (42507-320-06) / 12 TABLET, COAT... Sinus Pressure and Pain PE HYVEE INC 2025-10-22
46122-0443-62 2 BLISTER PACK in 1 CARTON (46122-443-62) / 12 TABLET in 1... Sinus Pressure Pain Maximum Strength, Non-Drowsy Amerisource Bergen 2005-06-23
50580-0435-01 2 BLISTER PACK in 1 CARTON (50580-435-01) / 12 TABLET, FILM... Sudafed PE Sinus Pressure Plus Pain Kenvue Brands LLC 2019-06-17
50580-0547-25 2 BLISTER PACK in 1 CARTON (50580-547-25) / 12 TABLET, FILM... SUDAFED PE Pressure Plus Pain Kenvue Brands LLC 2012-07-01
50580-0598-02 2 BLISTER PACK in 1 CARTON (50580-598-02) / 12 TABLET, FILM... TYLENOL SINUS PLUS HEADACHE DAY Kenvue Brands LLC 2019-05-08
50804-0123-05 2 PACKAGE in 1 CARTON (50804-123-05) / 12 TABLET, COATED in... Sinus and Headache GOODSENSE 2020-06-01
50804-0220-06 2 BLISTER PACK in 1 CARTON (50804-220-06) / 12 TABLET, COAT... sinus pressure and pain pe GOODSENSE 2020-08-01
50844-0467-02 1 BLISTER PACK in 1 CARTON (50844-467-02) / 12 TABLET, FILM... Sinus and Headache Daytime L.N.K. International, Inc. 2005-07-26
50844-0467-08 2 BLISTER PACK in 1 CARTON (50844-467-08) / 12 TABLET, FILM... Sinus and Headache Daytime L.N.K. International, Inc. 2005-07-26
51467-0008-01 2 BLISTER PACK in 1 BOX (51467-008-01) / 12 TABLET in 1 BLI... COLTALIN-ND FORTUNE PHARMACAL COMPANY LIMITED 2004-03-01
51467-0008-02 3 BLISTER PACK in 1 BOX (51467-008-02) / 12 TABLET in 1 BLI... COLTALIN-ND FORTUNE PHARMACAL COMPANY LIMITED 2016-04-26
51467-0013-01 2 BLISTER PACK in 1 BOX (51467-013-01) / 12 TABLET in 1 BLI... COLTALIN-ND FORTUNE PHARMACAL COMPANY LIMITED 2026-01-30
51467-0013-02 3 BLISTER PACK in 1 BOX (51467-013-02) / 12 TABLET in 1 BLI... COLTALIN-ND FORTUNE PHARMACAL COMPANY LIMITED 2026-01-30
53943-0220-06 2 BLISTER PACK in 1 PACKAGE (53943-220-06) / 12 TABLET, COA... Sinus Pressure plus Pain PE DISCOUNT DRUG MART 2020-09-01
53943-0323-05 2 BLISTER PACK in 1 CARTON (53943-323-05) / 12 TABLET, COAT... SINUS AND HEADACHE DISCOUNT DRUG MART 2020-09-01
55301-0446-08 2 BLISTER PACK in 1 CARTON (55301-446-08) / 12 TABLET, FILM... Sinus Headache and Pain Day, Non-drowsy ARMY AND AIR FORCE EXCHANGE SERVICE 2005-07-26
55301-0902-08 2 BLISTER PACK in 1 CARTON (55301-902-08) / 12 TABLET in 1... Suphedrine PE Sinus Pressure Plus Pain ARMY AND AIR FORCE EXCHANGE SERVICE 2021-09-16
55319-0496-08 2 BLISTER PACK in 1 CARTON (55319-496-08) / 12 TABLET, FILM... Sinus and Headache Family Dollar Services Inc 2024-01-02
55319-0702-08 2 BLISTER PACK in 1 CARTON (55319-702-08) / 12 TABLET in 1... Sinus Pressure and Pain Family Dollar Services Inc 2024-01-04
55910-0466-08 2 BLISTER PACK in 1 CARTON (55910-466-08) / 12 TABLET, FILM... Sinus and Headache Daytime DOLGENCORP, LLC 2005-07-26
55910-0925-08 2 BLISTER PACK in 1 CARTON (55910-925-08) / 12 TABLET in 1... Sinus Pressure and Pain Maximum Strength DOLGENCORP, LLC 2005-06-23
57344-0923-05 2 BLISTER PACK in 1 CARTON (57344-923-05) / 12 TABLET, COAT... Sinus and Headache AAA Pharmaceutical, Inc. 2020-08-01
59779-0466-08 2 BLISTER PACK in 1 CARTON (59779-466-08) / 12 TABLET, FILM... SINUS PAIN AND CONGESTION DAYTIME CVS Pharmacy 2005-07-26
59779-0779-08 1 KIT in 1 CARTON (59779-779-08) * 12 TABLET, FILM COATED... SINUS PAIN AND CONGESTION CVS Pharmacy 2005-07-26
59779-0802-08 2 BLISTER PACK in 1 CARTON (59779-802-08) / 12 TABLET in 1... Sinus PE Pressure plus Pain MAXIMUM STRENGTH CVS Pharmacy 2005-06-23
63868-0582-24 2 BLISTER PACK in 1 CARTON (63868-582-24) / 12 TABLET, COAT... Sinus plus Headache CHAIN DRUG MARKETING ASSOCIATION INC 2020-06-15
63941-0220-06 2 BLISTER PACK in 1 CARTON (63941-220-06) / 12 TABLET, COAT... Sinus Pressure plus Pain PE VALU MERCHANDISERS COMPANY 2020-10-01
67091-0209-24 2 BLISTER PACK in 1 CARTON (67091-209-24) / 12 TABLET in 1... Nasal Decongestant PE and Pain Relief Maximum Strength WinCo Foods, LLC 2005-06-23
67091-0213-24 2 BLISTER PACK in 1 CARTON (67091-213-24) / 12 TABLET, FILM... Sinus Congestion and Pain Relief Non-Drowsy WinCo Foods, LLC 2005-07-26
68998-0220-06 2 BLISTER PACK in 1 CARTON (68998-220-06) / 12 TABLET, COAT... Sinus Pressure plus Pain PE MARC GLASSMAN, INC. 2020-06-22
68998-0323-05 2 BLISTER PACK in 1 CARTON (68998-323-05) / 12 TABLET, COAT... Sinus plus Headache MARC GLASSMAN, INC. 2020-06-15
69168-0270-95 18 TABLET in 1 BLISTER PACK (69168-270-95) Sinus Headache PEMaximum Strength Non-Drowsy Maximum Strength Non-Drowsy Allegiant Health 2014-12-22
70000-0161-01 2 BLISTER PACK in 1 CARTON (70000-0161-1) / 12 TABLET in 1... Sinus Pressure and Pain Maximum Strength Cardinal Health 110, LLC. DBA Leader 2005-06-23
70000-0568-01 2 BLISTER PACK in 1 CARTON (70000-0568-1) / 12 TABLET, FILM... Sinus and Headache Cardinal Health 110, LLC. DBA Leader 2005-07-26
72036-0320-06 2 BLISTER PACK in 1 CARTON (72036-320-06) / 12 TABLET, COAT... Sinus Pressure plus Pain PE Harris Teeter 2020-06-19
Observed labelers: FORTUNE PHARMACAL COMPANY LIMITED (4) · Haleon US Holdings LLC (4) · Better Living Brands, LLC (3) · CVS Pharmacy (3) · Kenvue Brands LLC (3) · ARMY AND AIR FORCE EXCHANGE SERVICE (2) · +25 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.