Home › NDC Lookup › RxCUI directory › RxCUI 1049630

Diphenhydramine hydrochloride 25 MG Oral Tablet — RxCUI 1049630

RxNorm drug concept · Semantic clinical drug
RxCUI 1049630 Semantic clinical drug · SCD ● Current RxNorm concept 214 FDA products 359 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049630
Official nameDiphenhydramine hydrochloride 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG Oral Tablet
FDA products mapped214
Package NDCs mapped359
Reported Medicaid activity (SDUD)150,203 prescriptions · 38 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG Oral Tablet Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG Oral Tablet RxCUI 1049630

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 8

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Banophen 215558
    • Benadryl 203457
    • Nytol 1092413
    • Rest Simply 1101108
    • Simply Sleep 262241
    • Sominex 152371
    • Wal-Dryl Allergy 1090073
    • Wal-Sleep Z 1363470
  3. Dose forms 41

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Tablet 371892
    • Diphenhydramine hydrochloride Oral Tablet 2649122
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine Pill 1158450
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine hydrochloride Pill 2659100
    • Diphenhydramine Oral Tablet [Banophen] 369215
    • Diphenhydramine Oral Tablet [Benadryl] 369212
    • +33 more in this family
  4. Clinical & branded drugs 17

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 26 of 68 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Diphenhydramine Oral Tablet SCDF · 371892
  • Diphenhydramine hydrochloride Oral Tablet SCDFP · 2649122
  • Diphenhydramine Oral Product SCDG · 1158449
  • Diphenhydramine Pill SCDG · 1158450
  • Diphenhydramine hydrochloride Oral Product SCDGP · 2659104
  • Diphenhydramine hydrochloride Pill SCDGP · 2659100

Brand-Name Concepts

📦 FDA Products & Package NDCs

214 products · 359 package NDCs
359 package NDCs map to RxCUI 1049630 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00113-0431-62 12 BLISTER PACK in 1 CARTON (0113-0431-62) / 2 TABLET, FILM... good sense nighttime sleep aid L. Perrigo Company 2001-04-25
00113-0431-78 1 BOTTLE in 1 CARTON (0113-0431-78) / 100 TABLET, FILM COAT... good sense nighttime sleep aid L. Perrigo Company 2021-12-29
00113-0479-62 24 BLISTER PACK in 1 CARTON (0113-0479-62) / 1 TABLET in 1... good sense allergy relief L. Perrigo Company 1991-08-20
00113-0479-78 1 BOTTLE in 1 CARTON (0113-0479-78) / 100 TABLET in 1 BOTTL... good sense allergy relief L. Perrigo Company 1993-10-06
00113-0479-79 400 TABLET in 1 BOTTLE (0113-0479-79) good sense allergy relief L. Perrigo Company 2001-02-26
00363-0100-61 600 TABLET, FILM COATED in 1 BOTTLE (0363-0100-61) ALLERGY RELIEF WALGREENS 2021-12-31
00363-0100-65 365 TABLET, FILM COATED in 1 BOTTLE (0363-0100-65) ALLERGY RELIEF WALGREENS 2021-12-31
00363-0189-46 1 BOTTLE, PLASTIC in 1 CARTON (0363-0189-46) / 96 TABLET in... Sleep II Nighttime Sleep Aid Walgreen Company 1990-04-10
00363-0367-08 2 BLISTER PACK in 1 CARTON (0363-0367-08) / 12 TABLET, FILM... Sleep Aid Nighttime Walgreen Company 2000-06-10
00363-0367-12 1 BOTTLE, PLASTIC in 1 CARTON (0363-0367-12) / 100 TABLET,... Sleep Aid Nighttime Walgreen Company 2000-06-10
00363-0367-13 1 BOTTLE, PLASTIC in 1 CARTON (0363-0367-13) / 250 TABLET,... Sleep Aid Nighttime Walgreen Company 2000-06-10
00363-3291-07 3 BLISTER PACK in 1 CARTON (0363-3291-07) / 12 TABLET, FILM... Allergy Relief Walgreen Company 2024-12-30
00363-3291-08 2 BLISTER PACK in 1 CARTON (0363-3291-08) / 12 TABLET, FILM... Allergy Relief Walgreen Company 2021-09-27
00363-3291-12 1 BOTTLE, PLASTIC in 1 CARTON (0363-3291-12) / 100 TABLET,... Allergy Relief Walgreen Company 2021-09-27
00363-3291-22 4 BLISTER PACK in 1 CARTON (0363-3291-22) / 12 TABLET, FILM... Allergy Relief Walgreen Company 2021-09-27
00363-6141-12 1 BOTTLE, PLASTIC in 1 CARTON (0363-6141-12) / 100 TABLET,... Allergy Relief Walgreen Company 2021-09-23
00363-6720-12 1 BOTTLE, PLASTIC in 1 CARTON (0363-6720-12) / 100 TABLET,... Sleep Aid Walgreen Company 2022-03-18
00363-6720-51 365 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (0363-6720-51) Sleep Aid Walgreen Company 2022-03-18
00363-9023-36 365 TABLET, FILM COATED in 1 BOTTLE (0363-9023-36) Allergy Relief Walgreens 2022-05-31
00363-9024-60 600 TABLET, FILM COATED in 1 BOTTLE (0363-9024-60) Allergy Relief Walgreens 2022-06-14
00536-1214-29 100 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (0536-1214-29) Diphenhydramine HCl Rugby Laboratories 2019-03-28
00904-4274-51 1 BOTTLE, PLASTIC in 1 CARTON (0904-4274-51) / 50 TABLET in... Sleep Tabs Major Pharmaceuticals 1990-04-10
00904-5551-24 2 BLISTER PACK in 1 CARTON (0904-5551-24) / 12 TABLET, FILM... Banophen Major Pharmaceuticals 1990-03-02
00904-5551-59 1 BOTTLE, PLASTIC in 1 CARTON (0904-5551-59) / 100 TABLET,... Banophen Major Pharmaceuticals 1990-03-02
00924-0056-01 50 PACKET in 1 CARTON (0924-0056-01) / 1 TABLET, FILM COATE... PhysiciansCare Allergy Antihistamine Acme United Corporation 2017-11-01
11673-0494-01 1 BOTTLE in 1 CARTON (11673-494-01) / 100 TABLET in 1 BOTTL... Allergy Relief TARGET CORPORATION 2023-10-20
11673-0494-32 300 TABLET in 1 BOTTLE (11673-494-32) Allergy Relief TARGET CORPORATION 2023-10-20
11673-0496-01 1 BOTTLE in 1 CARTON (11673-496-01) / 100 TABLET in 1 BOTTL... Nighttime Sleep Aid TARGET CORPORATION 2024-01-15
11822-0329-01 365 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (11822-0329-1) Allergy Relief Rite Aid Corporation 1990-03-02
11822-0329-02 1 BOTTLE, PLASTIC in 1 CARTON (11822-0329-2) / 100 TABLET,... Allergy Relief Rite Aid Corporation 1990-03-02
11822-0329-04 4 BLISTER PACK in 1 CARTON (11822-0329-4) / 12 TABLET, FILM... Allergy Relief Rite Aid Corporation 1990-03-02
11822-0329-06 1 BOTTLE, PLASTIC in 1 CARTON (11822-0329-6) / 200 TABLET,... Allergy Relief Rite Aid Corporation 1990-03-02
11822-0329-08 2 BLISTER PACK in 1 CARTON (11822-0329-8) / 12 TABLET, FILM... Allergy Relief Rite Aid Corporation 1990-03-02
11822-0672-06 200 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (11822-0672-6) sleep aid Rite Aid Corporation 2015-07-24
11822-3670-02 1 BOTTLE, PLASTIC in 1 CARTON (11822-3670-2) / 100 TABLET,... Sleep Aid Rite Aid Corporation 2000-06-10
11822-3670-08 2 BLISTER PACK in 1 CARTON (11822-3670-8) / 12 TABLET, FILM... Sleep Aid Rite Aid Corporation 2000-06-10
17714-0135-01 100 TABLET in 1 BOTTLE (17714-135-01) Diphenhydramine Hydrochloride Advance Pharmaceutical Inc. 2006-09-26
21130-0329-06 1 BOTTLE, PLASTIC in 1 CARTON (21130-329-06) / 200 TABLET,... Allergy Relief Better Living Brands, LLC 1990-03-02
21130-0329-08 2 BLISTER PACK in 1 CARTON (21130-329-08) / 12 TABLET, FILM... Allergy Relief Better Living Brands, LLC 1990-03-02
21130-0329-12 1 BOTTLE, PLASTIC in 1 CARTON (21130-329-12) / 100 TABLET,... Allergy Relief Better Living Brands, LLC 1990-03-02
21130-0329-22 4 BLISTER PACK in 1 CARTON (21130-329-22) / 12 TABLET, FILM... Allergy Relief Better Living Brands, LLC 1990-03-02
21130-0596-01 1 BOTTLE in 1 CARTON (21130-596-01) / 100 TABLET in 1 BOTTL... Allergy Relief BETTER LIVING BRANDS LLC. 2023-05-31
21130-0596-20 1 BOTTLE in 1 CARTON (21130-596-20) / 200 TABLET in 1 BOTTL... Allergy Relief BETTER LIVING BRANDS LLC. 2023-05-31
21130-0596-35 365 TABLET in 1 BOTTLE (21130-596-35) Allergy Relief BETTER LIVING BRANDS LLC. 2023-07-27
21130-0763-06 1 BOTTLE in 1 CARTON (21130-763-06) / 200 TABLET, FILM COAT... Sleep Aid Nighttime Better Living Brands, LLC 2000-06-10
21130-0763-08 2 BLISTER PACK in 1 CARTON (21130-763-08) / 12 TABLET, FILM... Sleep Aid Nighttime Better Living Brands, LLC 2000-06-10
21130-0763-12 1 BOTTLE, PLASTIC in 1 CARTON (21130-763-12) / 100 TABLET,... Sleep Aid Nighttime Better Living Brands, LLC 2000-06-10
24385-0479-78 1 BOTTLE in 1 CARTON (24385-479-78) / 100 TABLET in 1 BOTTL... Good Neighbor Pharmacy allergy Amerisource Bergen 1998-03-12
29485-9285-02 25 POUCH in 1 BOX (29485-9285-2) / 2 TABLET, FILM COATED in... Allergy Relief Lil' Drug Store Products, Inc. 2016-07-11
29485-9285-03 30 POUCH in 1 BOX (29485-9285-3) / 2 TABLET, FILM COATED in... Allergy Relief Lil' Drug Store Products, Inc. 2016-07-11
Observed labelers: Lil' Drug Store Products, Inc. (18) · Kenvue Brands LLC (13) · CVS Pharmacy (11) · Walgreen Company (11) · Allegiant Health (10) · DOLGENCORP, LLC (9) · +102 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.