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Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet — RxCUI 1092189

RxNorm drug concept · Semantic clinical drug
RxCUI 1092189 Semantic clinical drug · SCD ● Current RxNorm concept 135 FDA products 237 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1092189
Official nameAcetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet; acetaminophen 500 MG / diphenhydrAMINE HCl 25 MG Oral Tablet
FDA products mapped135
Package NDCs mapped237
Reported Medicaid activity (SDUD)1,872 prescriptions · 9 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 500 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet RxCUI 1092189

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Brand names 3

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Acetadryl 1116529
    • Panadol PM 1094715
    • Tylenol PM 220581
  3. Dose forms 21

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Tablet 370518
    • Acetaminophen / diphenhydramine hydrochloride Oral Tablet 2647568
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen / diphenhydramine Pill 1151205
    • Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609
    • Acetaminophen / diphenhydramine hydrochloride Pill 2662105
    • Acetaminophen / diphenhydramine Oral Tablet [Acetadryl] 1116531
    • Acetaminophen / diphenhydramine Oral Tablet [Panadol PM] 1094717
    • +13 more in this family
  4. Clinical & branded drugs 8

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 23 of 36 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 500 MG SCDC · 315266
  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Acetaminophen / diphenhydramine Oral Tablet SCDF · 370518
  • Acetaminophen / diphenhydramine hydrochloride Oral Tablet SCDFP · 2647568
  • Acetaminophen / diphenhydramine Oral Product SCDG · 1151204
  • Acetaminophen / diphenhydramine Pill SCDG · 1151205
  • Acetaminophen / diphenhydramine hydrochloride Oral Product SCDGP · 2662609
  • Acetaminophen / diphenhydramine hydrochloride Pill SCDGP · 2662105

Brand-Name Concepts

  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Panadol PM] SBD · 1094718
  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM] SBD · 1092378
  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Acetadryl] SBD · 1116532
  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG [Acetadryl] SBDC · 1116530
  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG [Panadol PM] SBDC · 1094716
  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG [Tylenol PM] SBDC · 1092376
  • Acetaminophen / diphenhydramine Oral Tablet [Acetadryl] SBDF · 1116531
  • Acetaminophen / diphenhydramine Oral Tablet [Panadol PM] SBDF · 1094717
  • Acetaminophen / diphenhydramine Oral Tablet [Tylenol PM] SBDF · 1092377
  • Acetaminophen / diphenhydramine hydrochloride Oral Tablet [Acetadryl] SBDFP · 2656551

📦 FDA Products & Package NDCs

135 products · 237 package NDCs
237 package NDCs map to RxCUI 1092189 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00113-0437-71 1 BOTTLE in 1 CARTON (0113-0437-71) / 50 TABLET, FILM COATE... good sense pain relief pm extra strength L. Perrigo Company 1992-07-23
00113-0437-78 1 BOTTLE in 1 CARTON (0113-0437-78) / 100 TABLET, FILM COAT... good sense pain relief pm extra strength L. Perrigo Company 2021-05-24
00135-0608-01 1 BOTTLE in 1 CARTON (0135-0608-01) / 24 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2016-12-01
00135-0608-02 1 BOTTLE in 1 CARTON (0135-0608-02) / 50 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2016-12-01
00135-0608-03 50 PACKET in 1 CARTON (0135-0608-03) / 2 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2016-12-01
00135-7021-01 50 PACKET in 1 CARTON (0135-7021-01) / 2 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2022-05-19
00135-7021-02 1 BOTTLE in 1 CARTON (0135-7021-02) / 24 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2021-12-07
00135-7021-03 1 BOTTLE in 1 CARTON (0135-7021-03) / 50 TABLET, FILM COATE... PANADOL PM Haleon US Holdings LLC 2021-12-07
00363-0556-01 1 BOTTLE, PLASTIC in 1 CARTON (0363-0556-01) / 30 TABLET, C... Pain Reliever PM Extra Strength Walgreen Company 2007-12-17
00363-0556-09 1 BOTTLE, PLASTIC in 1 CARTON (0363-0556-09) / 20 TABLET, C... Pain Reliever PM Extra Strength Walgreen Company 2007-12-17
00363-0714-42 1 BOTTLE in 1 CARTON (0363-0714-42) / 24 TABLET in 1 BOTTLE Extra Strength NiteTime Pain Relief WALGREENS 2021-10-12
00363-0715-01 1 BOTTLE in 1 CARTON (0363-0715-01) / 100 TABLET in 1 BOTTL... Extra Strength Nite-Time Pain Relief WALGREENS 2021-10-12
00363-0760-10 1 BOTTLE, PLASTIC in 1 BOX (0363-0760-10) / 100 TABLET, COA... Pain Reliever PM Extra Strength Walgreens 2015-08-31
00363-0760-50 1 BOTTLE, PLASTIC in 1 BOX (0363-0760-50) / 50 TABLET, COAT... Pain Reliever PM Extra Strength Walgreens 2015-08-31
00363-0863-10 1 BOTTLE, PLASTIC in 1 BOX (0363-0863-10) / 100 TABLET, COA... Pain Reliever PM Extra strength Walgreens 2019-10-30
00363-0863-15 150 TABLET, COATED in 1 BOTTLE, PLASTIC (0363-0863-15) Pain Reliever PM Extra strength Walgreens 2019-10-30
00363-0863-24 1 BOTTLE, PLASTIC in 1 BOX (0363-0863-24) / 24 TABLET, COAT... Pain Reliever PM Extra strength Walgreens 2019-10-30
00363-0863-25 250 TABLET, COATED in 1 BOTTLE, PLASTIC (0363-0863-25) Pain Reliever PM Extra strength Walgreens 2019-10-30
00363-2035-08 1 BOTTLE, PLASTIC in 1 CARTON (0363-2035-08) / 24 TABLET, F... Pain Reliever PM Walgreen Company 1994-05-15
00363-9085-15 1 BOTTLE in 1 CARTON (0363-9085-15) / 15 TABLET in 1 BOTTLE EXTRA STRENGTH PAIN RELIEVER PM WALGREENS CO. 2023-04-13
00363-9661-15 150 TABLET in 1 BOTTLE (0363-9661-15) Acetaminophen Diphenhydramine HCL Walgreens 2024-07-23
00363-9661-25 250 TABLET in 1 BOTTLE (0363-9661-25) Acetaminophen Diphenhydramine HCL Walgreens 2024-07-23
00363-9664-37 375 TABLET in 1 BOTTLE (0363-9664-37) Acetaminophen Diphenhydramine HCL WALGREENS CO. 2024-07-13
00363-9664-60 125 TABLET in 1 BOTTLE (0363-9664-60) Acetaminophen Diphenhydramine HCL WALGREENS CO. 2022-09-30
00363-9799-75 75 TABLET in 1 BOTTLE (0363-9799-75) Acetaminophen Diphenhydramine HCL WALGREEN CO. 2023-03-03
00904-6731-51 1 BOTTLE in 1 CARTON (0904-6731-51) / 50 TABLET, FILM COATE... Acetaminophen PM Major Pharmaceuticals 2018-12-26
11673-0754-10 1 BOTTLE, PLASTIC in 1 BOX (11673-754-10) / 100 TABLET, COA... Pain Reliever PM TARGET Corporation 2023-08-01
11822-0556-01 80 TABLET, COATED in 1 BOTTLE, PLASTIC (11822-0556-1) Pain Relief Acetaminophen PM Rite Aid Corporation 2007-12-17
11822-2350-02 1 BOTTLE, PLASTIC in 1 CARTON (11822-2350-2) / 100 TABLET,... Pain Relief Acetaminophen PM Extra Strength Rite Aid Corporation 1994-05-15
11822-2350-05 1 BOTTLE, PLASTIC in 1 CARTON (11822-2350-5) / 50 TABLET, F... Pain Relief Acetaminophen PM Extra Strength Rite Aid Corporation 1994-05-15
11822-2350-07 300 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (11822-2350-7) Pain Relief Acetaminophen PM Extra Strength Rite Aid Corporation 1994-05-15
11822-2350-08 1 BOTTLE, PLASTIC in 1 CARTON (11822-2350-8) / 24 TABLET, F... Pain Relief Acetaminophen PM Extra Strength Rite Aid Corporation 2023-04-03
11822-2350-09 1 BOTTLE, PLASTIC in 1 CARTON (11822-2350-9) / 150 TABLET,... Pain Relief Acetaminophen PM Extra Strength Rite Aid Corporation 2023-03-16
17714-0133-50 50 TABLET in 1 BOTTLE (17714-133-50) ACETAMINOPHEN PM Advance Pharmaceutical Inc. 2002-01-09
21130-0095-01 1 BOTTLE, PLASTIC in 1 CARTON (21130-095-01) / 24 TABLET, C... Pain Relief PM Safeway 2015-12-23
21130-0095-03 1 BOTTLE, PLASTIC in 1 CARTON (21130-095-03) / 100 TABLET,... Pain Relief PM Safeway 2015-12-23
21130-0095-14 200 TABLET, COATED in 1 BOTTLE, PLASTIC (21130-095-14) Pain Relief PM Safeway 2015-12-23
21130-0224-18 1 BOTTLE in 1 CARTON (21130-224-18) / 80 TABLET in 1 BOTTLE Acetaminophen and Diphenhydramine hydrochloride Better Living Brands, LLC 2023-11-18
21130-0224-73 1 BOTTLE in 1 CARTON (21130-224-73) / 20 TABLET in 1 BOTTLE Acetaminophen and Diphenhydramine hydrochloride Better Living Brands, LLC 2023-11-18
21130-0354-02 20 TABLET in 1 BOTTLE (21130-354-02) Acetaminophen Diphenhydramine HCl BETTER LIVING BRANDS LLC. 2022-12-12
21130-0354-08 80 TABLET in 1 BOTTLE (21130-354-08) Acetaminophen Diphenhydramine HCl BETTER LIVING BRANDS LLC. 2022-12-12
21130-0661-10 100 TABLET in 1 BOTTLE (21130-661-10) Acetaminophen and Diphenhydramine HCL SAFEWAY 2023-06-30
21130-0661-20 200 TABLET in 1 BOTTLE (21130-661-20) Acetaminophen and Diphenhydramine HCL SAFEWAY 2023-06-30
21130-0661-24 24 TABLET in 1 BOTTLE (21130-661-24) Acetaminophen and Diphenhydramine HCL SAFEWAY 2023-06-30
30142-0193-14 1 BOTTLE in 1 CARTON (30142-193-14) / 50 TABLET in 1 BOTTLE Acetaminophen and Diphenhydramine hydrochloride KROGER COMPANY 2021-03-06
30142-0755-01 1 BOTTLE in 1 CARTON (30142-755-01) / 100 TABLET in 1 BOTTL... Extra Strength Acetaminophen PM KROGER COMPANY 2021-05-01
30142-0755-05 1 BOTTLE in 1 CARTON (30142-755-05) / 50 TABLET in 1 BOTTLE Extra Strength Acetaminophen PM KROGER COMPANY 2021-05-01
30142-0755-20 2 BOTTLE in 1 CARTON (30142-755-20) / 100 TABLET in 1 BOTTL... Extra Strength Acetaminophen PM KROGER COMPANY 2021-05-01
36800-0095-03 1 BOTTLE, PLASTIC in 1 CARTON (36800-095-03) / 100 TABLET,... Pain Relief PM Extra Strength TopCo Associates LLC 2012-11-30
36800-0095-17 225 TABLET, COATED in 1 BOTTLE, PLASTIC (36800-095-17) Pain Relief PM Extra Strength TopCo Associates LLC 2019-03-21
Observed labelers: Walgreens (10) · WALMART INC. (10) · Kenvue Brands LLC (8) · Lil' Drug Store Products, Inc. (8) · Meijer, Inc. (8) · Allegiant Health (6) · +88 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.