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Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM] — RxCUI 1092378

RxNorm drug concept · Semantic branded drug
RxCUI 1092378 Semantic branded drug · SBD ● Current RxNorm concept 11 FDA products 25 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1092378
Official nameAcetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 500 MG / Diphenhydramine Hydrochloride 25 MG Oral Tablet [Tylenol PM]; Tylenol PM 500 MG / 25 MG Oral Tablet; Tylenol PM Extra Strength (APAP 500 MG / diphenhydramine hydrochloride 25 MG) Oral Tablet
FDA products mapped11
Package NDCs mapped25
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 500 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet [Tylenol PM] RxCUI 1092378

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Tylenol PM 220581
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Tablet 370518
    • Acetaminophen / diphenhydramine hydrochloride Oral Tablet 2647568
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen / diphenhydramine Pill 1151205
    • Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609
    • Acetaminophen / diphenhydramine hydrochloride Pill 2662105
    • Acetaminophen / diphenhydramine Oral Tablet [Tylenol PM] 1092377
    • Acetaminophen / diphenhydramine hydrochloride Oral Tablet [Tylenol PM] 2654810
    • +5 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 17 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet SCD · 1092189
  • Acetaminophen 500 MG SCDC · 315266
  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Acetaminophen / diphenhydramine Oral Tablet SCDF · 370518
  • Acetaminophen / diphenhydramine hydrochloride Oral Tablet SCDFP · 2647568
  • Acetaminophen / diphenhydramine Oral Product SCDG · 1151204
  • Acetaminophen / diphenhydramine Pill SCDG · 1151205
  • Acetaminophen / diphenhydramine hydrochloride Oral Product SCDGP · 2662609
  • Acetaminophen / diphenhydramine hydrochloride Pill SCDGP · 2662105

Brand-Name Concepts

  • Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG [Tylenol PM] SBDC · 1092376
  • Acetaminophen / diphenhydramine Oral Tablet [Tylenol PM] SBDF · 1092377
  • Acetaminophen / diphenhydramine hydrochloride Oral Tablet [Tylenol PM] SBDFP · 2654810
  • Tylenol PM Oral Product SBDG · 1187313
  • Tylenol PM Pill SBDG · 1187314
  • Tylenol PM BN · 220581

📦 FDA Products & Package NDCs

11 products · 25 package NDCs
25 package NDCs map to RxCUI 1092378 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
50269-0552-01 20 POUCH in 1 BOX (50269-552-01) / 2 TABLET, FILM COATED in... Tylenol PM JC World Bell Wholesale Co., Inc. 2016-07-11
50269-0608-06 25 TABLET, FILM COATED in 1 BOX (50269-608-06) Tylenol PM JC World Bell Wholesale Co., Inc. 2018-08-16
50580-0608-01 1 BOTTLE in 1 CARTON (50580-608-01) / 24 TABLET, FILM COATE... Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-02 1 BOTTLE in 1 CARTON (50580-608-02) / 100 TABLET, FILM COAT... Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-03 1 BOTTLE in 1 CARTON (50580-608-03) / 150 TABLET, FILM COAT... Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-04 1 BOTTLE in 1 CARTON (50580-608-04) / 225 TABLET, FILM COAT... Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-05 2 TABLET, FILM COATED in 1 POUCH (50580-608-05) Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-06 50 POUCH in 1 TRAY (50580-608-06) / 2 TABLET, FILM COATED i... Tylenol PM Extra Strength Kenvue Brands LLC 2016-07-11
50580-0608-07 2 POUCH in 1 CARTON (50580-608-07) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength Kenvue Brands LLC 2022-02-14
50580-0608-08 1 BOTTLE in 1 CARTON (50580-608-08) / 50 TABLET, FILM COATE... Tylenol PM Extra Strength Kenvue Brands LLC 2022-06-01
53209-1002-02 25 BLISTER PACK in 1 POUCH (53209-1002-2) / 2 TABLET, FILM... Tylenol PM Extra Strength Morning Star OTC 2025-06-19
66715-6417-02 2 POUCH in 1 CARTON (66715-6417-2) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength, CVP HEALTH Lil' Drug Store Products, Inc. 2022-10-11
66715-6417-07 25 POUCH in 1 CARTON (66715-6417-7) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength, CVP HEALTH Lil' Drug Store Products, Inc. 2022-04-19
66715-6417-08 30 POUCH in 1 CARTON (66715-6417-8) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength, CVP HEALTH Lil' Drug Store Products, Inc. 2022-04-19
66715-6517-02 2 POUCH in 1 CARTON (66715-6517-2) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength, CVP HEALTH Lil' Drug Store Products, Inc. 2022-05-06
66715-9817-02 2 POUCH in 1 CARTON (66715-9817-2) / 2 TABLET, FILM COATED... Lil Drug Store Tylenol PM Extra Strength Lil' Drug Store Products, Inc. 2017-10-20
66715-9817-03 3 POUCH in 1 CARTON (66715-9817-3) / 2 TABLET, FILM COATED... Lil Drug Store Tylenol PM Extra Strength Lil' Drug Store Products, Inc. 2019-08-15
67414-0608-00 2500 POUCH in 1 BOX (67414-608-00) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength Jones Healthcare Group - Packaging Services, Inc 2018-01-25
67414-0608-06 50 POUCH in 1 TRAY (67414-608-06) / 2 TABLET, FILM COATED i... Tylenol PM Extra Strength Jones Healthcare Group - Packaging Services, Inc 2018-01-25
67751-0241-01 1 POUCH in 1 CARTON (67751-241-01) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength Navajo Manufacturing Company Inc. 2025-03-11
67751-0241-02 2 POUCH in 1 CARTON (67751-241-02) / 2 TABLET, FILM COATED... Tylenol PM Extra Strength Navajo Manufacturing Company Inc. 2025-09-23
70264-0028-01 50 POUCH in 1 BOX (70264-028-01) / 2 TABLET, FILM COATED in... TYLENOL PM EXTRA STRENGTH R J General Corporation 2021-05-01
73097-0013-02 1 POUCH in 1 CARTON (73097-013-02) / 2 TABLET, FILM COATED... Tylenol PM Savings Distributors LLC 2019-07-22
73097-0013-40 20 POUCH in 1 CARTON (73097-013-40) / 2 TABLET, FILM COATED... Tylenol PM Savings Distributors LLC 2019-07-22
73097-0013-50 25 POUCH in 1 CARTON (73097-013-50) / 2 TABLET, FILM COATED... Tylenol PM Savings Distributors LLC 2019-07-22
Observed labelers: Kenvue Brands LLC (8) · Lil' Drug Store Products, Inc. (6) · Savings Distributors LLC (3) · JC World Bell Wholesale Co., Inc. (2) · Jones Healthcare Group - Packaging Services, Inc (2) · Navajo Manufacturing Company Inc. (2) · +2 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.