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Acetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet — RxCUI 1101534

Name: Acetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet (RxCUI 1101534)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 1101534 Semantic clinical drug · SCD ● Current RxNorm concept 8 FDA products 17 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1101534

Official nameAcetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asAPAP 500 MG / Phenylephrine Hydrochloride 5 MG Oral Tablet; acetaminophen 500 MG / phenylephrine HCl 5 MG Oral Tablet

FDA products mapped8

Package NDCs mapped17

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
Can I use the nasal spray if I have high blood pressure or heart disease?

📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 500 MG / phenylephrine hydrochlori... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet RxCUI 1101534 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 4

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Phenylephrine 8163 IN
- Acetaminophen / phenylephrine 214186 MIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / phenylephrine Oral Tablet 373379 SCDF
- Acetaminophen / phenylephrine hydrochloride Oral Tablet 2649220 SCDFP
- Acetaminophen / phenylephrine Oral Product 1151913 SCDG
- Acetaminophen / phenylephrine Pill 1151914 SCDG
- Acetaminophen / phenylephrine hydrochloride Oral Product 2663092 SCDGP
- Acetaminophen / phenylephrine hydrochloride Pill 2662558 SCDGP
- Oral Tablet 317541 DF
- Oral Product 1151131 DFG
- +1 more in this family
Clinical & branded drugs 2

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 500 MG 315266 SCDC
- Phenylephrine hydrochloride 5 MG 1020198 SCDC
Packs 1

Fixed collections of drugs packaged and sold together, like dose packs.
- {1 (acetaminophen 500 MG / chlorpheniramine maleate 2 MG / phenylephrine hydrochloride 5 MG Oral Tablet) / 1 (acetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet) } Pack 1101555 GPCK

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 500 MG SCDC · 315266
Phenylephrine hydrochloride 5 MG SCDC · 1020198
Acetaminophen / phenylephrine Oral Tablet SCDF · 373379
Acetaminophen / phenylephrine hydrochloride Oral Tablet SCDFP · 2649220
Acetaminophen / phenylephrine Oral Product SCDG · 1151913
Acetaminophen / phenylephrine Pill SCDG · 1151914
Acetaminophen / phenylephrine hydrochloride Oral Product SCDGP · 2663092
Acetaminophen / phenylephrine hydrochloride Pill SCDGP · 2662558
{1 (acetaminophen 500 MG / chlorpheniramine maleate 2 MG / phenylephrine hydrochloride 5 MG Oral Tablet) / 1 (acetaminophen 500 MG / phenylephrine hydrochloride 5 MG Oral Tablet) } Pack GPCK · 1101555

📦 FDA Products & Package NDCs

8 products · 17 package NDCs

17 package NDCs map to RxCUI 1101534 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
47682-0001-33	50 PACKET in 1 BOX (47682-001-33) / 2 TABLET in 1 PACKET	Green Guard Advanced Sinus Relief	Unifirst First Aid Corporation	2008-12-30
47682-0001-48	125 PACKET in 1 BOX (47682-001-48) / 2 TABLET in 1 PACKET (...	Green Guard Advanced Sinus Relief	Unifirst First Aid Corporation	2008-12-30
47682-0001-99	2 TABLET in 1 PACKET (47682-001-99)	Green Guard Advanced Sinus Relief	Unifirst First Aid Corporation	2008-12-30
47682-0509-03	150 PACKET in 1 BOX (47682-509-03) / 2 TABLET in 1 PACKET (...	Otis Clapp Mygrex	Unifirst First Aid Corporation	2008-12-30
47682-0509-99	2 TABLET in 1 PACKET (47682-509-99)	Otis Clapp Mygrex	Unifirst First Aid Corporation	2008-12-30
47682-0819-13	250 PACKET in 1 BOX (47682-819-13) / 2 TABLET in 1 PACKET (...	Medi First Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
47682-0819-33	50 PACKET in 1 BOX (47682-819-33) / 2 TABLET in 1 PACKET	Medi First Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
47682-0819-48	125 PACKET in 1 BOX (47682-819-48) / 2 TABLET in 1 PACKET	Medi First Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
47682-0819-50	25 PACKET in 1 BOX (47682-819-50) / 2 TABLET in 1 PACKET	Medi First Sinus Pain and Pressure	Unifirst First Aid Corporation	2019-04-16
47682-0819-99	2 TABLET in 1 PACKET (47682-819-99)	Medi First Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
47682-0919-33	50 PACKET in 1 BOX (47682-919-33) / 2 TABLET in 1 PACKET	Medi First Plus Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
47682-0919-48	125 PACKET in 1 BOX (47682-919-48) / 2 TABLET in 1 PACKET	Medi First Plus Sinus Pain and Pressure	Unifirst First Aid Corporation	2008-12-30
68599-4751-03	250 PACKET in 1 BOX (68599-4751-3) / 2 TABLET in 1 PACKET	McKesson Sinus Pain and Pressure Relief	McKesson Medical-Surgical	2022-09-01
73598-1192-01	50 PACKET in 1 BOX (73598-1192-1) / 2 TABLET in 1 PACKET	Pain and Sinus	JHK Inc dba American Safety & First Aid	2024-05-09
73598-1194-01	250 PACKET in 1 BOX (73598-1194-1) / 2 TABLET in 1 PACKET	Pain and Sinus Reliever	JHK DBA American Safety & First Aid	2024-05-09
84269-2546-01	50 PACKET in 1 BOX (84269-2546-1) / 2 TABLET in 1 PACKET	Sinu-Phen Plus Sinus Pain and Pressure	Wildman Business Group	2024-07-01
84269-2546-02	125 PACKET in 1 BOX (84269-2546-2) / 2 TABLET in 1 PACKET	Sinu-Phen Plus Sinus Pain and Pressure	Wildman Business Group	2024-07-01

Observed labelers: Unifirst First Aid Corporation (12) · Wildman Business Group (2) · JHK DBA American Safety & First Aid (1) · JHK Inc dba American Safety & First Aid (1) · McKesson Medical-Surgical (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.