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24 HR naproxen 375 MG Extended Release Oral Tablet — RxCUI 1116320

RxNorm drug concept · Semantic clinical drug
RxCUI 1116320 Semantic clinical drug · SCD ● Current RxNorm concept 14 FDA products 14 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1116320
Official name24 HR naproxen 375 MG Extended Release Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asnaproxen 375 MG (naproxen sodium 413 MG) 24 HR Extended Release Oral Tablet; naproxen sodium 375 MG 24HR Extended Release Oral Tablet
FDA products mapped14
Package NDCs mapped14
Reported Medicaid activity (SDUD)2,868 prescriptions · 8 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Naproxen: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • They're very similar — naproxen sodium is just the salt form of naproxen, and it dissolves in water more quickly. That means your body absorbs naproxen sodium a bit faster, so it t...
  • What's the difference between naproxen and naproxen sodium — are they the same thing?
  • You can take it either way, but taking it with food, milk, or a full glass of water is a good idea because it helps protect your stomach. Naproxen can irritate the lining of your s...
  • Can I take naproxen on an empty stomach, or do I need to eat first?
📖 Read our full Naproxen guide →

🕸️ Concept Web — How 24 HR naproxen 375 MG Extended Release Oral Tabl... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept 24 HR naproxen 375 MG Extended Release Oral Tablet RxCUI 1116320

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Naproxen 7258
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Naprelan 218599
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Naproxen Extended Release Oral Tablet 373006
    • Naproxen Oral Product 1157517
    • Naproxen Pill 1157518
    • Naproxen Extended Release Oral Tablet [Naprelan] 369974
    • Naprelan Oral Product 1178761
    • Naprelan Pill 1178762
    • Extended Release Oral Tablet 316945
    • Oral Product 1151131
    • +1 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 13 of 14 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Naproxen 375 MG SCDC · 316327
  • Naproxen Extended Release Oral Tablet SCDF · 373006
  • Naproxen Oral Product SCDG · 1157517
  • Naproxen Pill SCDG · 1157518

Brand-Name Concepts

📦 FDA Products & Package NDCs

14 products · 14 package NDCs
14 package NDCs map to RxCUI 1116320 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00480-0951-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0480-... Naproxen Sodium Teva Pharmaceuticals, Inc. 2022-11-01
00480-0952-58 75 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0480-0... Naproxen sodium Teva Pharmaceuticals, Inc. 2022-11-01
00480-0953-56 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0480-0... Naproxen Sodium Teva Pharmaceuticals, Inc. 2022-11-01
24979-0249-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979... Naprelan Upsher-Smith Laboratories, LLC 2025-12-31
24979-0250-68 75 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979-... Naprelan Upsher-Smith Laboratories, LLC 2025-12-31
24979-0251-06 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979-... Naprelan Upsher-Smith Laboratories, LLC 2025-12-31
24979-0252-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979... Naproxen Sodium Upsher-Smith Laboratories, LLC 2024-04-25
24979-0253-68 75 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979-... Naproxen Sodium Upsher-Smith Laboratories, LLC 2024-04-25
24979-0254-06 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (24979-... Naproxen Sodium Upsher-Smith Laboratories, LLC 2024-04-25
47781-0153-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (47781... Naproxen Sodium Alvogen Inc. 2015-03-11
47781-0154-75 75 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (47781-... Naproxen Sodium Alvogen Inc. 2015-03-11
52427-0272-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (52427... Naprelan Almatica Pharma LLC 2014-01-17
52427-0273-75 75 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (52427-... Naprelan Almatica Pharma LLC 2014-01-17
69420-1375-01 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69420... Naproxen Sodium SA3, LLC 2019-05-01
Observed labelers: Upsher-Smith Laboratories, LLC (6) · Teva Pharmaceuticals, Inc. (3) · Almatica Pharma LLC (2) · Alvogen Inc. (2) · SA3, LLC (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.