Home › NDC Lookup › RxCUI directory › RxCUI 1189316

Acetaminophen 500 MG / dextromethorphan hydrobromide 20 MG / phenylephrine hydrochloride 1... — RxCUI 1189316

RxNorm drug concept · Semantic clinical drug
RxCUI 1189316 Semantic clinical drug · SCD ● Current RxNorm concept 17 FDA products 18 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1189316
Official nameAcetaminophen 500 MG / dextromethorphan hydrobromide 20 MG / phenylephrine hydrochloride 10 MG Granules for Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 500 MG / dextromethorphan HBr 20 MG / phenylephrine HCl 10 MG Packet for Oral Solution; acetaminophen 500 MG / dextromethorphan HBr 20 MG / phenylephrine HCl 10 MG Granules for Oral Solution; acetaminophen 500 MG / dextromethorphan hydrobromide 20 MG / phenylephrine hydrochloride 10 MG Powder for Oral Solution; APAP 500 MG / Dextromethorphan Hydrobromide 20 MG / Phenylephrine Hydrochloride 10 MG Granules for Oral Solution
FDA products mapped17
Package NDCs mapped18
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
  • I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
  • You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
  • Can I use the nasal spray if I have high blood pressure or heart disease?
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 500 MG / dextromethorphan hydrobro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / dextromethorphan hydrobromide 20 MG / phenylephrine hydrochloride 10 MG Granules for Oral Solution RxCUI 1189316

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 6

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Dextromethorphan 3289
    • Phenylephrine 8163
    • Acetaminophen / dextromethorphan / phenylephrine 705259
    • Dextromethorphan hydrobromide 102490
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / dextromethorphan / phenylephrine Granules for Oral Solution 1659966
    • Acetaminophen / dextromethorphan hydrobromide / phenylephrine hydrochloride Granules for Oral Solution 2646840
    • Acetaminophen / dextromethorphan / phenylephrine Granule Product 1659965
    • Acetaminophen / dextromethorphan / phenylephrine Oral Product 1155918
    • Acetaminophen / dextromethorphan hydrobromide / phenylephrine hydrochloride Granule Product 2660413
    • Acetaminophen / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Product 2660748
    • Granules for Oral Solution 1540453
    • Granule Product 1294708
    • +1 more in this family
  3. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 500 MG 315266
    • Dextromethorphan hydrobromide 20 MG 1037200
    • Phenylephrine hydrochloride 10 MG 996705
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 18 of 19 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

17 products · 18 package NDCs
18 package NDCs map to RxCUI 1189316 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-6426-06 6 PACKET in 1 CARTON (0067-6426-06) / 237 mL in 1 PACKET (0... THERAFLU MULTI-SYMPTOM SEVERE COLD Haleon US Holdings LLC 2014-07-01
00067-6802-02 6 PACKET in 1 CARTON (0067-6802-02) / 237 mL in 1 PACKET THERAFLU Severe Cold Relief Daytime Haleon US Holdings LLC 2023-01-20
00067-6804-02 1 KIT in 1 PACKAGE, COMBINATION (0067-6804-02) * 6 PACKET... Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime Haleon US Holdings LLC 2023-01-20
00067-7919-12 1 KIT in 1 PACKAGE, COMBINATION (0067-7919-12) * 6 PACKET... Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough Haleon US Holdings LLC 2016-01-01
00067-8200-01 1 KIT in 1 PACKAGE, COMBINATION (0067-8200-01) * 6 PACKET... Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough Haleon US Holdings LLC 2019-09-01
00363-5470-06 6 POWDER, FOR SOLUTION in 1 CARTON (0363-5470-06) Multi Symptom Wal Flu Severe Cold WALGREEN CO. 2018-05-31
00363-5480-12 1 KIT in 1 CARTON (0363-5480-12) * 6 PACKET in 1 CARTON (0... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough WALGREEN CO. 2018-06-22
11673-0877-55 1 KIT in 1 CARTON (11673-877-55) * 1 POWDER, FOR SOLUTION... Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough Target Corporation 2021-07-16
49035-0907-91 6 PACKET in 1 CARTON (49035-907-91) / 1 POWDER, FOR SOLUTIO... Equate Severe Cold Multi Symptom Wal-Mart Stores Inc 2016-07-18
49035-0948-12 1 KIT in 1 CARTON (49035-948-12) * 6 PACKET in 1 CARTON (7... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough WAL-MART STORES INC 2019-07-01
55910-0509-91 6 POWDER, FOR SOLUTION in 1 CARTON (55910-509-91) DG HEALTH MULTI SYMPTOM SEVERE COLD Dolgencorp, LLC 2017-05-22
58933-0542-16 1 KIT in 1 PACKAGE (58933-542-16) * 5 g in 1 PACKET (58933... Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2022-07-20
58933-0550-01 5 g in 1 PACKET (58933-550-01) Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2023-03-22
58933-0550-08 8 PACKET in 1 PACKAGE (58933-550-08) / 5 g in 1 PACKET Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2023-03-22
59779-0768-12 1 KIT in 1 CARTON (59779-768-12) * 6 POWDER, FOR SOLUTION... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough CVS Pharmacy,Inc. 2015-09-21
68163-0547-06 6 POWDER, FOR SOLUTION in 1 CARTON (68163-547-06) Multi Symptom Severe Cold RARITAN PHARMACEUTICALS INC 2019-04-10
72288-0191-55 1 KIT in 1 CARTON (72288-191-55) * 1 POWDER, FOR SOLUTION... basic care daytime severe cold and flu nighttime severe cold cough and flu Amazon.com Services LLC 2023-05-31
72288-0303-91 6 POWDER, FOR SOLUTION in 1 CARTON (72288-303-91) Basic Care Severe Cold and Flu Amazon.com Services LLC 2021-08-11
Observed labelers: Haleon US Holdings LLC (5) · Procter & Gamble Manufactura S de RL de CV (3) · Amazon.com Services LLC (2) · WAL-MART STORES INC (2) · WALGREEN CO. (2) · CVS Pharmacy,Inc. (1) · +3 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.