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Diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solu... — RxCUI 1236048

Name: Diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral… (RxCUI 1236048)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 1236048 Semantic clinical drug · SCD ● Current RxNorm concept 12 FDA products 12 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1236048

Official nameDiphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asdiphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 10 ML Oral Solution; diphenhydrAMINE HCl 6.25 MG / phenylephrine HCl 2.5 MG in 5 mL Oral Solution; diphenhydramine HCl 6.25 MG / phenylephrine HCl 2.5 MG per 5 ML Oral Solution

FDA products mapped12

Package NDCs mapped12

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
What can I actually use this cream or spray for?
You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...

📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 1.25 MG/ML / pheny... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution RxCUI 1236048 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 5

The active substance itself — no strength, form, or brand attached yet.
- Diphenhydramine 3498 IN
- Phenylephrine 8163 IN
- Diphenhydramine / phenylephrine 690693 MIN
- Diphenhydramine hydrochloride 1362 PIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Diphenhydramine / phenylephrine Oral Solution 692769 SCDF
- Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Solution 2646978 SCDFP
- Diphenhydramine / phenylephrine Oral Liquid Product 1158428 SCDG
- Diphenhydramine / phenylephrine Oral Product 1158429 SCDG
- Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Liquid Product 2663527 SCDGP
- Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2662612 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 2

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Diphenhydramine hydrochloride 1.25 MG/ML 1049883 SCDC
- Phenylephrine hydrochloride 0.5 MG/ML 707273 SCDC
Packs 2

Fixed collections of drugs packaged and sold together, like dose packs.
- {1 (brompheniramine maleate 0.2 MG/ML / dextromethorphan hydrobromide 1 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) / 1 (diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) } Pack 1666116 GPCK
- {1 (dextromethorphan hydrobromide 1 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) / 1 (diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) } Pack 1730190 GPCK

Showing up to 8 concepts per family — 17 of 18 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

{1 (brompheniramine maleate 0.2 MG/ML / dextromethorphan hydrobromide 1 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) / 1 (diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) } Pack GPCK · 1666116
Diphenhydramine hydrochloride 1.25 MG/ML SCDC · 1049883
Phenylephrine hydrochloride 0.5 MG/ML SCDC · 707273
Diphenhydramine / phenylephrine Oral Solution SCDF · 692769
Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Solution SCDFP · 2646978
Diphenhydramine / phenylephrine Oral Liquid Product SCDG · 1158428
Diphenhydramine / phenylephrine Oral Product SCDG · 1158429
Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Liquid Product SCDGP · 2663527
Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product SCDGP · 2662612
{1 (dextromethorphan hydrobromide 1 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) / 1 (diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution) } Pack GPCK · 1730190

📦 FDA Products & Package NDCs

12 products · 12 package NDCs

12 package NDCs map to RxCUI 1236048 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00363-0058-04	118 mL in 1 BOTTLE, PLASTIC (0363-0058-04)	Cold and Congestion Childrens Nighttime	Walgreens	2016-03-31
00363-4590-08	1 KIT in 1 KIT (0363-4590-08) * 118 mL in 1 BOTTLE, PLASTI...	Daytime Cold and Cough and NightTime Cold and Congestion Childrens	Walgreens	2022-03-04
11673-0059-08	1 KIT in 1 KIT (11673-059-08) * 118 mL in 1 BOTTLE, PLASTI...	Daytime Cold and Cough and NightTime Cold and Congestion Childrens	TARGET Corporation	2015-07-31
21130-0379-04	1 BOTTLE, PLASTIC in 1 BOX (21130-379-04) / 118 mL in 1 BOT...	Childrens Cold and Cough Nighttime	Safeway, Inc.	2015-12-31
49580-0379-04	1 BOTTLE, PLASTIC in 1 BOX (49580-0379-4) / 118 mL in 1 BOT...	Childrens Triacting Nighttime Cold and Cough ReadyInCase	P & L Development, LLC	2014-11-30
51316-0939-04	1 KIT in 1 KIT (51316-939-04) * 1 BOTTLE in 1 CARTON (5131...	Daytime Cold and Cough Nighttime Cold and Congestion	CVS	2025-01-31
63941-0984-04	1 BOTTLE, PLASTIC in 1 BOX (63941-984-04) / 118 mL in 1 BOT...	Nighttime Cold and Cough childrens	Best Choice (Valu Merchandisers Company)	2022-06-10
80070-0340-04	1 BOTTLE in 1 CARTON (80070-340-04) / 118 mL in 1 BOTTLE	Dimetapp Nighttime Cold and Congestion	Foundation Consumer Brands	2021-09-15
80070-0350-08	1 KIT in 1 CARTON (80070-350-08) * 1 BOTTLE in 1 CARTON (8...	Dimetapp Cold and Cough and Nighttime Cold and Congestion	Foundation Consumer Brands	2021-09-15
80070-0360-12	1 KIT in 1 CARTON (80070-360-12) * 1 BOTTLE in 1 CARTON (8...	Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion	Foundation Consumer Brands	2021-09-15
82442-0536-08	1 KIT in 1 KIT (82442-536-08) * 118 mL in 1 BOTTLE, PLASTI...	TARGET CHILDRENS DT AND NT COLD and COUGH	TARGET CORPORATION	2024-06-14
82673-0103-04	1 BOTTLE in 1 BOX (82673-103-04) / 118 mL in 1 BOTTLE	Childrens Nighttime Cold and Cough	KinderFarms, LLC	2022-04-29

Observed labelers: Foundation Consumer Brands (3) · TARGET Corporation (2) · Walgreens (2) · Best Choice (Valu Merchandisers Company) (1) · CVS (1) · KinderFarms, LLC (1) · +2 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.