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Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet [Imodium Multi-Symptom Reli... — RxCUI 1426827

RxNorm drug concept · Semantic branded drug
RxCUI 1426827 Semantic branded drug · SBD ● Current RxNorm concept 1 FDA product 5 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1426827
Official nameLoperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet [Imodium Multi-Symptom Relief]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asImodium Multi-Symptom Relief (loperamide HCl 2 MG / simethicone 125 MG) Oral Tablet; Imodium Multi-Symptom Relief 2 MG / 125 MG Oral Tablet
FDA products mapped1
Package NDCs mapped5
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Loperamide: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It controls the symptoms of diarrhea, including travelers' diarrhea in over-the-counter products. Prescription-labeled capsules are also used for chronic diarrhea in adults with in...
  • Take it by mouth, usually after loose stools, following the label chart for your age and weight. Drink lots of clear fluids so you don't get dehydrated. With liquids, shake well an...
  • No. Taking more than directed can cause serious, even fatal, heart rhythm problems. If diarrhea lasts more than 2 days or gets worse, stop and call your doctor.
  • Can I take extra if the diarrhea isn't stopping?
📖 Read our full Loperamide guide →

🕸️ Concept Web — How Loperamide hydrochloride 2 MG / simethicone 125... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet [Imodium Multi-Symptom Relief] RxCUI 1426827

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Loperamide 6468
    • Simethicone 9796
    • Loperamide / simethicone 214681
    • Loperamide hydrochloride 82038
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Imodium Multi-Symptom Relief 1426822
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Loperamide / simethicone Oral Tablet 378714
    • Loperamide hydrochloride / simethicone Oral Tablet 2645977
    • Loperamide / simethicone Oral Product 1165325
    • Loperamide / simethicone Pill 1165326
    • Loperamide hydrochloride / simethicone Oral Product 2661327
    • Loperamide hydrochloride / simethicone Pill 2662231
    • Loperamide / simethicone Oral Tablet [Imodium Multi-Symptom Relief] 1426824
    • Loperamide hydrochloride / simethicone Oral Tablet [Imodium Multi-Symptom Relief] 2657374
    • +5 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 17 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet SCD · 978001
  • Loperamide hydrochloride 2 MG SCDC · 977997
  • Simethicone 125 MG SCDC · 317493
  • Loperamide / simethicone Oral Tablet SCDF · 378714
  • Loperamide hydrochloride / simethicone Oral Tablet SCDFP · 2645977
  • Loperamide / simethicone Oral Product SCDG · 1165325
  • Loperamide / simethicone Pill SCDG · 1165326
  • Loperamide hydrochloride / simethicone Oral Product SCDGP · 2661327
  • Loperamide hydrochloride / simethicone Pill SCDGP · 2662231

Brand-Name Concepts

  • Loperamide hydrochloride 2 MG / simethicone 125 MG [Imodium Multi-Symptom Relief] SBDC · 1426823
  • Loperamide / simethicone Oral Tablet [Imodium Multi-Symptom Relief] SBDF · 1426824
  • Loperamide hydrochloride / simethicone Oral Tablet [Imodium Multi-Symptom Relief] SBDFP · 2657374
  • Imodium Multi-Symptom Relief Oral Product SBDG · 1426825
  • Imodium Multi-Symptom Relief Pill SBDG · 1426826
  • Imodium Multi-Symptom Relief BN · 1426822

📦 FDA Products & Package NDCs

1 product · 5 package NDCs
5 package NDCs map to RxCUI 1426827 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
50580-0338-06 1 BLISTER PACK in 1 CARTON (50580-338-06) / 6 TABLET in 1 B... IMODIUM Multi-Symptom Relief Kenvue Brands LLC 2025-03-31
50580-0338-12 2 BLISTER PACK in 1 CARTON (50580-338-12) / 6 TABLET in 1 B... IMODIUM Multi-Symptom Relief Kenvue Brands LLC 2008-07-01
50580-0338-18 3 BLISTER PACK in 1 CARTON (50580-338-18) / 6 TABLET in 1 B... IMODIUM Multi-Symptom Relief Kenvue Brands LLC 2008-07-01
50580-0338-61 4 BLISTER PACK in 1 CARTON (50580-338-61) / 6 TABLET in 1 B... IMODIUM Multi-Symptom Relief Kenvue Brands LLC 2019-06-24
50580-0338-64 4 BLISTER PACK in 1 CARTON (50580-338-64) / 6 TABLET in 1 B... IMODIUM Multi-Symptom Relief Kenvue Brands LLC 2024-02-26
Observed labelers: Kenvue Brands LLC (5) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.