Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet — RxCUI 978001
RxNorm drug concept · Semantic clinical drug
RxCUI 978001
Semantic clinical drug · SCD
● Current RxNorm concept 39 FDA products
73 package NDCs
Snapshot Jul 14, 2026
What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.
🗂️ Key Facts
RxCUI978001
Official nameLoperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asloperamide HCl 2 MG / simethicone 125 MG Oral Tablet
FDA products mapped39
Package NDCs mapped73
Reported Medicaid activity (SDUD)220 prescriptions · 5 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026
📖 Skip the Codes — Read It in Plain English.
Our pharmacist-built guide to Loperamide: what it is, how it’s used, side effects, and interactions.
📗 Our plain-language guide HelloPharmacist
- It controls the symptoms of diarrhea, including travelers' diarrhea in over-the-counter products. Prescription-labeled capsules are also used for chronic diarrhea in adults with in...
- Take it by mouth, usually after loose stools, following the label chart for your age and weight. Drink lots of clear fluids so you don't get dehydrated. With liquids, shake well an...
- No. Taking more than directed can cause serious, even fatal, heart rhythm problems. If diarrhea lasts more than 2 days or gets worse, stop and call your doctor.
- Can I take extra if the diarrhea isn't stopping?
🕸️ Concept Web — How Loperamide hydrochloride 2 MG / simethicone 125... Connects
One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept
Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet
RxCUI 978001 Semantic clinical drug · SCD
Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.
-
Ingredients 4
The active substance itself — no strength, form, or brand attached yet.
-
Loperamide
6468IN -
Simethicone
9796IN -
Loperamide / simethicone
214681MIN -
Loperamide hydrochloride
82038PIN
-
Loperamide
-
Brand names 1
The same medicine's trade names. A brand name alone says nothing about strength or form.
-
Imodium Multi-Symptom Relief
1426822BN
-
Imodium Multi-Symptom Relief
-
Dose forms 13
The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
-
Loperamide / simethicone Oral Tablet
378714SCDF -
Loperamide hydrochloride / simethicone Oral Tablet
2645977SCDFP -
Loperamide / simethicone Oral Product
1165325SCDG -
Loperamide / simethicone Pill
1165326SCDG -
Loperamide hydrochloride / simethicone Oral Product
2661327SCDGP -
Loperamide hydrochloride / simethicone Pill
2662231SCDGP -
Loperamide / simethicone Oral Tablet [Imodium Multi-Symptom Relief]
1426824SBDF -
Loperamide hydrochloride / simethicone Oral Tablet [Imodium Multi-Symptom Relief]
2657374SBDFP - +5 more in this family
-
Loperamide / simethicone Oral Tablet
-
Clinical & branded drugs 4
Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
-
Loperamide hydrochloride 2 MG
977997SCDC -
Simethicone 125 MG
317493SCDC -
Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet [Imodium Multi-Symptom Relief]
1426827SBD -
Loperamide hydrochloride 2 MG / simethicone 125 MG [Imodium Multi-Symptom Relief]
1426823SBDC
-
Loperamide hydrochloride 2 MG
Showing up to 8 concepts per family — 17 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.
🔀 Generic ⇄ Brand Crosswalk
The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.
Generic (Clinical) Concepts
-
Loperamide hydrochloride 2 MG
SCDC · 977997 -
Simethicone 125 MG
SCDC · 317493 -
Loperamide / simethicone Oral Tablet
SCDF · 378714 -
Loperamide hydrochloride / simethicone Oral Tablet
SCDFP · 2645977 -
Loperamide / simethicone Oral Product
SCDG · 1165325 -
Loperamide / simethicone Pill
SCDG · 1165326 -
Loperamide hydrochloride / simethicone Oral Product
SCDGP · 2661327 -
Loperamide hydrochloride / simethicone Pill
SCDGP · 2662231
Brand-Name Concepts
-
Loperamide hydrochloride 2 MG / simethicone 125 MG Oral Tablet [Imodium Multi-Symptom Relief]
SBD · 1426827 -
Loperamide hydrochloride 2 MG / simethicone 125 MG [Imodium Multi-Symptom Relief]
SBDC · 1426823 -
Loperamide / simethicone Oral Tablet [Imodium Multi-Symptom Relief]
SBDF · 1426824 -
Loperamide hydrochloride / simethicone Oral Tablet [Imodium Multi-Symptom Relief]
SBDFP · 2657374 -
Imodium Multi-Symptom Relief Oral Product
SBDG · 1426825 -
Imodium Multi-Symptom Relief Pill
SBDG · 1426826 -
Imodium Multi-Symptom Relief
BN · 1426822
📦 FDA Products & Package NDCs
39 products · 73 package NDCs
73 package NDCs map to RxCUI 978001 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
| Package NDC | Package | Brand / generic name | Labeler | Marketing start |
|---|---|---|---|---|
| 00113-0087-53 | 12 BLISTER PACK in 1 CARTON (0113-0087-53) / 1 TABLET in 1... | good sense anti diarrheal anti gas | L. Perrigo Company | 2018-10-11 |
| 00113-0087-62 | 24 BLISTER PACK in 1 CARTON (0113-0087-62) / 1 TABLET in 1... | good sense anti diarrheal anti gas | L. Perrigo Company | 2019-06-10 |
| 00113-1087-89 | 18 BLISTER PACK in 1 CARTON (0113-1087-89) / 1 TABLET in 1... | Good Sense Anti Diarrheal Anti Gas | L. Perrigo Company | 2019-01-29 |
| 00363-1830-53 | 12 BLISTER PACK in 1 CARTON (0363-1830-53) / 1 TABLET in 1... | anti diarrheal and anti gas | Walgreen Company | 2018-10-10 |
| 00363-1830-62 | 24 BLISTER PACK in 1 CARTON (0363-1830-62) / 1 TABLET in 1... | anti diarrheal and anti gas | Walgreen Company | 2019-06-25 |
| 00363-9606-75 | 2 BLISTER PACK in 1 CARTON (0363-9606-75) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | WALGREEN CO. | 2022-08-03 |
| 00363-9606-76 | 4 BLISTER PACK in 1 CARTON (0363-9606-76) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | WALGREEN CO. | 2022-08-03 |
| 11673-0646-62 | 24 BLISTER PACK in 1 CARTON (11673-646-62) / 1 TABLET in 1... | up and up anti diarrheal anti gas | Target Corporation | 2021-01-06 |
| 11673-0646-89 | 18 BLISTER PACK in 1 CARTON (11673-646-89) / 1 TABLET in 1... | up and up anti diarrheal anti gas | Target Corporation | 2019-03-14 |
| 21130-0183-62 | 24 BLISTER PACK in 1 CARTON (21130-183-62) / 1 TABLET in 1... | signature care anti diarrheal anti gas | Safeway | 2019-06-25 |
| 21130-0183-89 | 18 BLISTER PACK in 1 CARTON (21130-183-89) / 1 TABLET in 1... | signature care anti diarrheal anti gas | Safeway | 2018-10-10 |
| 21130-0222-24 | 4 BLISTER PACK in 1 CARTON (21130-222-24) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Better Living Brands, LLC | 2023-07-21 |
| 21130-0222-76 | 3 BLISTER PACK in 1 CARTON (21130-222-76) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Better Living Brands, LLC | 2023-07-21 |
| 30142-0581-53 | 12 BLISTER PACK in 1 CARTON (30142-581-53) / 1 TABLET in 1... | Anti Diarrheal Anti Gas | Kroger Company | 2019-04-24 |
| 30142-0581-62 | 24 BLISTER PACK in 1 CARTON (30142-581-62) / 1 TABLET in 1... | Anti Diarrheal Anti Gas | Kroger Company | 2020-02-07 |
| 37808-0714-53 | 12 BLISTER PACK in 1 CARTON (37808-714-53) / 1 TABLET in 1... | anti diarrheal anti gas | H E B | 2018-11-15 |
| 37808-0714-62 | 24 BLISTER PACK in 1 CARTON (37808-714-62) / 1 TABLET in 1... | anti diarrheal anti gas | H E B | 2020-02-03 |
| 41163-0553-89 | 18 BLISTER PACK in 1 CARTON (41163-553-89) / 1 TABLET in 1... | equaline anti diarrheal plus anti gas | United Natural Foods, Inc. dba UNFI | 2019-12-04 |
| 41250-0375-62 | 24 BLISTER PACK in 1 CARTON (41250-375-62) / 1 TABLET in 1... | anti diarrheal plus anti gas | Meijer Distribution Inc | 2020-02-03 |
| 41250-0375-89 | 18 BLISTER PACK in 1 CARTON (41250-375-89) / 1 TABLET in 1... | anti diarrheal plus anti gas | Meijer Distribution Inc | 2018-10-16 |
| 41520-0772-53 | 12 BLISTER PACK in 1 CARTON (41520-772-53) / 1 TABLET in 1... | CareOne Diarrhea and Gas Control | American Sales Company | 2019-01-31 |
| 42507-0699-53 | 12 BLISTER PACK in 1 CARTON (42507-699-53) / 1 TABLET in 1... | anti diarrheal anti gas | HyVee Inc | 2026-02-25 |
| 42507-0699-62 | 24 BLISTER PACK in 1 CARTON (42507-699-62) / 1 TABLET in 1... | anti diarrheal anti gas | HyVee Inc | 2026-02-25 |
| 46122-0620-62 | 24 BLISTER PACK in 1 CARTON (46122-620-62) / 1 TABLET in 1... | good neighbor pharmacy anti diarrheal anti gas | Amerisource Bergen | 2020-06-24 |
| 50580-0338-06 | 1 BLISTER PACK in 1 CARTON (50580-338-06) / 6 TABLET in 1 B... | IMODIUM Multi-Symptom Relief | Kenvue Brands LLC | 2025-03-31 |
| 50580-0338-12 | 2 BLISTER PACK in 1 CARTON (50580-338-12) / 6 TABLET in 1 B... | IMODIUM Multi-Symptom Relief | Kenvue Brands LLC | 2008-07-01 |
| 50580-0338-18 | 3 BLISTER PACK in 1 CARTON (50580-338-18) / 6 TABLET in 1 B... | IMODIUM Multi-Symptom Relief | Kenvue Brands LLC | 2008-07-01 |
| 50580-0338-61 | 4 BLISTER PACK in 1 CARTON (50580-338-61) / 6 TABLET in 1 B... | IMODIUM Multi-Symptom Relief | Kenvue Brands LLC | 2019-06-24 |
| 50580-0338-64 | 4 BLISTER PACK in 1 CARTON (50580-338-64) / 6 TABLET in 1 B... | IMODIUM Multi-Symptom Relief | Kenvue Brands LLC | 2024-02-26 |
| 51660-0069-06 | 6 TABLET in 1 BLISTER PACK (51660-069-06) | Loperamide HCl and Simethicone | Ohm Laboratories Inc. | 2022-01-13 |
| 51660-0069-12 | 2 BLISTER PACK in 1 CARTON (51660-069-12) / 6 TABLET in 1 B... | Loperamide HCl and Simethicone | Ohm Laboratories Inc. | 2022-01-13 |
| 51660-0069-18 | 3 BLISTER PACK in 1 CARTON (51660-069-18) / 6 TABLET in 1 B... | Loperamide HCl and Simethicone | Ohm Laboratories Inc. | 2022-01-13 |
| 51660-0069-24 | 4 BLISTER PACK in 1 CARTON (51660-069-24) / 6 TABLET in 1 B... | Loperamide HCl and Simethicone | Ohm Laboratories Inc. | 2022-01-13 |
| 53041-0263-50 | 1 BLISTER PACK in 1 CARTON (53041-263-50) / 6 TABLET in 1 B... | Loperamide Hydrochloride, Simethicone | Guardian Drug Company | 2021-06-01 |
| 53943-0263-33 | 4 BLISTER PACK in 1 CARTON (53943-263-33) / 6 TABLET in 1 B... | Anti-Diarrheal/Anti-Gas | Discount Drug Mart, Inc | 2025-02-26 |
| 55319-0052-75 | 2 BLISTER PACK in 1 CARTON (55319-052-75) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Family Dollar Stores, LLC | 2023-08-11 |
| 55910-0383-53 | 12 BLISTER PACK in 1 CARTON (55910-383-53) / 1 TABLET in 1... | dg health anti diarrheal anti gas | Dolgencorp, LLC | 2018-10-09 |
| 55910-0383-62 | 24 BLISTER PACK in 1 CARTON (55910-383-62) / 1 TABLET in 1... | dg health anti diarrheal anti gas | Dolgencorp, LLC | 2022-04-07 |
| 55910-0383-89 | 18 BLISTER PACK in 1 CARTON (55910-383-89) / 1 TABLET in 1... | dg health anti diarrheal anti gas | Dolgencorp, LLC | 2018-10-09 |
| 56062-0511-62 | 24 BLISTER PACK in 1 CARTON (56062-511-62) / 1 TABLET in 1... | antidiarrheal multi symptom relief | Publix Super Markets Inc | 2020-08-03 |
| 58602-0815-74 | 1 BLISTER PACK in 1 CARTON (58602-815-74) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2020-12-14 |
| 58602-0815-75 | 2 BLISTER PACK in 1 CARTON (58602-815-75) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2020-12-14 |
| 58602-0815-76 | 4 BLISTER PACK in 1 CARTON (58602-815-76) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2020-12-14 |
| 58602-0815-80 | 3 BLISTER PACK in 1 CARTON (58602-815-80) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2020-12-14 |
| 58602-0868-76 | 4 BLISTER PACK in 1 CARTON (58602-868-76) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2021-02-24 |
| 58602-0869-76 | 4 BLISTER PACK in 1 CARTON (58602-869-76) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2021-02-24 |
| 58602-0869-80 | 3 BLISTER PACK in 1 CARTON (58602-869-80) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Aurohealth LLC | 2021-05-16 |
| 62207-0739-69 | 2 BLISTER PACK in 1 CARTON (62207-739-69) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Granules India Ltd | 2023-03-01 |
| 69230-0325-04 | 1 BLISTER PACK in 1 CARTON (69230-325-04) / 4 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Camber Consumer Care Inc | 2021-06-17 |
| 69230-0325-06 | 1 BLISTER PACK in 1 CARTON (69230-325-06) / 6 TABLET in 1 B... | Loperamide Hydrochloride and Simethicone | Camber Consumer Care Inc | 2021-06-17 |
Observed labelers:
Aurohealth LLC (7) ·
Camber Consumer Care Inc (6) ·
Kenvue Brands LLC (5) ·
Ohm Laboratories Inc. (4) ·
WALMART INC. (4) ·
Bionpharma Inc. (3)
· +28 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.
💲 Pricing (NADAC)
NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.
Per ea · median
$0.2892
Range $0.2892–$0.2892
· middle 50% $0.2892–$0.2892
· 6 NDCs
Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.
🗃️ Sources & Limits
Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
- A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
- Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
- Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
- Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.