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0.4 ML methotrexate 25 MG/ML Auto-Injector — RxCUI 1441402

RxNorm drug concept · Semantic clinical drug
RxCUI 1441402 Semantic clinical drug · SCD ● Current RxNorm concept 7 FDA products 21 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1441402
Official name0.4 ML methotrexate 25 MG/ML Auto-Injector
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asmethotrexate 10 MG per 0.4 ML Auto-Injector; methotrexate 10 MG in 0.4 ML Auto-Injector
FDA products mapped7
Package NDCs mapped21
Reported Medicaid activity (SDUD)1,295 prescriptions · 10 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Methotrexate Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes — for rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis, once weekly is the correct and intended schedule. This is actually one of the most important safety po...
  • Why am I only taking this once a week? Is that really enough?
  • Common things like mild nausea, tiredness, or mouth soreness are expected and your team can help you manage them. But you should call your doctor immediately — or go to the ER — if...
  • What side effects should I just watch for, versus which ones mean I should call someone right away?
📖 Read our full Methotrexate Injection guide →

🕸️ Concept Web — How 0.4 ML methotrexate 25 MG/ML Auto-Injector Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept 0.4 ML methotrexate 25 MG/ML Auto-Injector RxCUI 1441402

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Methotrexate 6851
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Otrexup 1441403
  3. Dose forms 6

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Methotrexate Auto-Injector 1655203
    • Methotrexate Injectable Product 1162235
    • Methotrexate Auto-Injector [Otrexup] 1655205
    • Otrexup Injectable Product 1441406
    • Auto-Injector 1649570
    • Injectable Product 1151126
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 11 of 11 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Methotrexate 25 MG/ML SCDC · 328406
  • Methotrexate Auto-Injector SCDF · 1655203
  • Methotrexate Injectable Product SCDG · 1162235

Brand-Name Concepts

📦 FDA Products & Package NDCs

7 products · 21 package NDCs
21 package NDCs map to RxCUI 1441402 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
54436-0010-01 1 SYRINGE in 1 CARTON (54436-010-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0010-03 1 SYRINGE in 1 CARTON (54436-010-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0010-04 4 SYRINGE in 1 CARTON (54436-010-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2013-10-11
54436-0012-01 1 SYRINGE in 1 CARTON (54436-012-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0012-03 1 SYRINGE in 1 CARTON (54436-012-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0012-04 4 SYRINGE in 1 CARTON (54436-012-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2016-03-24
54436-0015-01 1 SYRINGE in 1 CARTON (54436-015-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0015-03 1 SYRINGE in 1 CARTON (54436-015-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0015-04 4 SYRINGE in 1 CARTON (54436-015-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2013-10-11
54436-0017-01 1 SYRINGE in 1 CARTON (54436-017-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0017-03 1 SYRINGE in 1 CARTON (54436-017-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0017-04 4 SYRINGE in 1 CARTON (54436-017-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2016-03-24
54436-0020-01 1 SYRINGE in 1 CARTON (54436-020-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0020-03 1 SYRINGE in 1 CARTON (54436-020-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0020-04 4 SYRINGE in 1 CARTON (54436-020-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2013-10-11
54436-0022-01 1 SYRINGE in 1 CARTON (54436-022-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0022-03 1 SYRINGE in 1 CARTON (54436-022-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2016-03-24
54436-0022-04 4 SYRINGE in 1 CARTON (54436-022-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2016-03-24
54436-0025-01 1 SYRINGE in 1 CARTON (54436-025-01) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0025-03 1 SYRINGE in 1 CARTON (54436-025-03) / .4 mL in 1 SYRINGE Otrexup Antares Pharma, Inc. 2013-10-11
54436-0025-04 4 SYRINGE in 1 CARTON (54436-025-04) / .4 mL in 1 SYRINGE (... Otrexup Antares Pharma, Inc. 2013-10-11
Observed labelers: Antares Pharma, Inc. (21) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.