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Acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG... — RxCUI 1536477

RxNorm drug concept · Semantic clinical drug
RxCUI 1536477 Semantic clinical drug · SCD ● Current RxNorm concept 8 FDA products 16 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1536477
Official nameAcetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Effervescent Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 250 MG / Chlorpheniramine Maleate 2 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine Hydrochloride 5 MG Effervescent Oral Tablet; acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Effervescent Oral Tablet
FDA products mapped8
Package NDCs mapped16
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

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  • Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
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🕸️ Concept Web — How Acetaminophen 250 MG / chlorpheniramine maleate... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Effervescent Oral Tablet RxCUI 1536477

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 8

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Chlorpheniramine 2400
    • Dextromethorphan 3289
    • Phenylephrine 8163
    • Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine 689580
    • Chlorpheniramine maleate 142429
    • Dextromethorphan hydrobromide 102490
    • Phenylephrine hydrochloride 8164
  2. Dose forms 6

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Effervescent Oral Tablet 1536476
    • Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Effervescent Oral Tablet 2646315
    • Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Product 1154903
    • Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Product 2659525
    • Effervescent Oral Tablet 1535727
    • Oral Product 1151131
  3. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 250 MG 315259
    • Chlorpheniramine maleate 2 MG 999433
    • Dextromethorphan hydrobromide 10 MG 1014455
    • Phenylephrine hydrochloride 5 MG 1020198

Showing up to 8 concepts per family — 18 of 18 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 250 MG SCDC · 315259
  • Chlorpheniramine maleate 2 MG SCDC · 999433
  • Dextromethorphan hydrobromide 10 MG SCDC · 1014455
  • Phenylephrine hydrochloride 5 MG SCDC · 1020198
  • Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Effervescent Oral Tablet SCDF · 1536476
  • Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Effervescent Oral Tablet SCDFP · 2646315
  • Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Product SCDG · 1154903
  • Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Product SCDGP · 2659525

📦 FDA Products & Package NDCs

8 products · 16 package NDCs
16 package NDCs map to RxCUI 1536477 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00280-0088-01 20 POUCH in 1 CARTON (0280-0088-01) / 2 TABLET, EFFERVESCEN... Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz Bayer HealthCare LLC. 2022-04-05
00280-0088-02 12 POUCH in 1 CARTON (0280-0088-02) / 2 TABLET, EFFERVESCEN... Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz Bayer HealthCare LLC. 2023-03-08
00280-8268-01 2 TABLET, EFFERVESCENT in 1 POUCH (0280-8268-01) ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
00280-8268-16 8 POUCH in 1 CARTON (0280-8268-16) / 2 TABLET, EFFERVESCENT... ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
00280-8268-24 12 POUCH in 1 CARTON (0280-8268-24) / 2 TABLET, EFFERVESCEN... ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
00280-8268-48 24 POUCH in 1 CARTON (0280-8268-48) / 2 TABLET, EFFERVESCEN... ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
00280-8268-72 36 POUCH in 1 CARTON (0280-8268-72) / 2 TABLET, EFFERVESCEN... ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
00280-8271-24 12 POUCH in 1 CARTON (0280-8271-24) / 2 TABLET, EFFERVESCEN... ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve Bayer HealthCare LLC. 2026-06-01
66715-6531-02 2 POUCH in 1 CARTON (66715-6531-2) / 2 TABLET, EFFERVESCENT... Alka-Seltzer Plus Cold and Flu, CVP Lil' Drug Store Products, Inc. 2022-08-01
66715-7831-02 2 POUCH in 1 CARTON (66715-7831-2) / 2 TABLET, EFFERVESCENT... Alka-Seltzer Plus Cold and Flu, BASIX Lil' Drug Store Products, Inc. 2022-11-30
66715-9831-02 2 POUCH in 1 CARTON (66715-9831-2) / 2 TABLET, EFFERVESCENT... Alka-Seltzer Plus Cold and Flu Lil' Drug Store Products, Inc. 2022-04-25
66715-9831-08 25 TABLET, EFFERVESCENT in 1 BOX, UNIT-DOSE (66715-9831-8) Alka-Seltzer Plus Cold and Flu Lil' Drug Store Products, Inc. 2022-04-27
66715-9831-09 30 TABLET, EFFERVESCENT in 1 BOX, UNIT-DOSE (66715-9831-9) Alka-Seltzer Plus Cold and Flu Lil' Drug Store Products, Inc. 2022-05-17
67751-0217-01 1 POUCH in 1 CARTON (67751-217-01) / 1 TABLET, EFFERVESCENT... Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz Navajo Manufacturing Company Inc. 2022-06-01
67751-0217-02 1 POUCH in 1 CARTON (67751-217-02) / 2 TABLET, EFFERVESCENT... Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz Navajo Manufacturing Company Inc. 2022-06-01
70264-0016-01 30 POUCH in 1 CARTON (70264-016-01) / 2 TABLET, EFFERVESCEN... Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz R J General Corporation 2023-03-16
Observed labelers: Bayer HealthCare LLC. (8) · Lil' Drug Store Products, Inc. (5) · Navajo Manufacturing Company Inc. (2) · R J General Corporation (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.