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Acetaminophen 80 MG / phenylephrine hydrochloride 2.5 MG Chewable Tablet — RxCUI 1539545

Name: Acetaminophen 80 MG / phenylephrine hydrochloride 2.5 MG Chewable Tablet (RxCUI 1539545)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 1539545 Semantic clinical drug · SCD ● Current RxNorm concept 1 FDA product 2 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1539545

Official nameAcetaminophen 80 MG / phenylephrine hydrochloride 2.5 MG Chewable Tablet

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asAPAP 80 MG / Phenylephrine Hydrochloride 2.5 MG Chewable Tablet; acetaminophen 80 MG / phenylephrine HCl 2.5 MG Chewable Tablet

FDA products mapped1

Package NDCs mapped2

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
Can I use the nasal spray if I have high blood pressure or heart disease?

📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 80 MG / phenylephrine hydrochlorid... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 80 MG / phenylephrine hydrochloride 2.5 MG Chewable Tablet RxCUI 1539545 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 4

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Phenylephrine 8163 IN
- Acetaminophen / phenylephrine 214186 MIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 12

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / phenylephrine Chewable Tablet 373376 SCDF
- Acetaminophen / phenylephrine hydrochloride Chewable Tablet 2647083 SCDFP
- Acetaminophen / phenylephrine Chewable Product 1295491 SCDG
- Acetaminophen / phenylephrine Oral Product 1151913 SCDG
- Acetaminophen / phenylephrine Pill 1151914 SCDG
- Acetaminophen / phenylephrine hydrochloride Chewable Product 2660903 SCDGP
- Acetaminophen / phenylephrine hydrochloride Oral Product 2663092 SCDGP
- Acetaminophen / phenylephrine hydrochloride Pill 2662558 SCDGP
- +4 more in this family
Clinical & branded drugs 2

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 80 MG 315270 SCDC
- Phenylephrine hydrochloride 2.5 MG 998604 SCDC

Showing up to 8 concepts per family — 14 of 18 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 80 MG SCDC · 315270
Phenylephrine hydrochloride 2.5 MG SCDC · 998604
Acetaminophen / phenylephrine Chewable Tablet SCDF · 373376
Acetaminophen / phenylephrine hydrochloride Chewable Tablet SCDFP · 2647083
Acetaminophen / phenylephrine Chewable Product SCDG · 1295491
Acetaminophen / phenylephrine Oral Product SCDG · 1151913
Acetaminophen / phenylephrine Pill SCDG · 1151914
Acetaminophen / phenylephrine hydrochloride Chewable Product SCDGP · 2660903
Acetaminophen / phenylephrine hydrochloride Oral Product SCDGP · 2663092
Acetaminophen / phenylephrine hydrochloride Pill SCDGP · 2662558

📦 FDA Products & Package NDCs

1 product · 2 package NDCs

2 package NDCs map to RxCUI 1539545 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
53145-0006-02	50 PACKET in 1 CARTON (53145-006-02) / 2 TABLET, CHEWABLE i...	Defensolito	Menper Distributors, Inc.	2012-02-21
53145-0006-30	1 BOTTLE in 1 BOX (53145-006-30) / 30 TABLET, CHEWABLE in 1...	Defensolito	Menper Distributors, Inc.	2012-02-21

Observed labelers: Menper Distributors, Inc. (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.