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Piperacillin 4000 MG / tazobactam 500 MG Injection [Zosyn] — RxCUI 1659151

Name: Piperacillin 4000 MG / tazobactam 500 MG Injection [Zosyn] (RxCUI 1659151)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic branded drug

RxCUI 1659151 Semantic branded drug · SBD ● Current RxNorm concept 6 FDA products 6 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1659151

Official namePiperacillin 4000 MG / tazobactam 500 MG Injection [Zosyn]

Concept typeSemantic branded drug (SBD)

RxNorm statusCurrent RxNorm concept

Also known asZosyn (piperacillin / tazobactam) 4.5 GM Injection; Zosyn 4.5 GM Injection

FDA products mapped6

Package NDCs mapped6

Reported Medicaid activity (SDUD)4,202 prescriptions · 22 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Piperacillin and Tazobactam Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It treats certain serious bacterial infections, such as abdominal infections, pneumonia, skin infections, and female pelvic infections. Which ones apply depends on your age. It doe...
It is given through a vein, usually over about 30 minutes, every 6 to 8 hours. Your care team handles the dosing and timing. They set the length of treatment, often 7 to 14 days.
Diarrhea, constipation, nausea, headache, trouble sleeping, and mild rash are the most common. Most are mild. Tell your nurse if anything bothers you.
Tell your team immediately about trouble breathing, swelling, a spreading rash or peeling skin, seizures, muscle pain with dark urine, or unusual bleeding. Also report severe diarr...

📖 Read our full Piperacillin and Tazobactam Injection guide →

🕸️ Concept Web — How Piperacillin 4000 MG / tazobactam 500 MG Injecti... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Piperacillin 4000 MG / tazobactam 500 MG Injection [Zosyn] RxCUI 1659151 Semantic branded drug · SBD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 3

The active substance itself — no strength, form, or brand attached yet.
- Piperacillin 8339 IN
- Tazobactam 37617 IN
- Piperacillin / tazobactam 74169 MIN
Brand names 1

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Zosyn 74170 BN
Dose forms 6

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Piperacillin / tazobactam Injection 1659130 SCDF
- Piperacillin / tazobactam Injectable Product 1159278 SCDG
- Piperacillin / tazobactam Injection [Zosyn] 1659133 SBDF
- Zosyn Injectable Product 1186325 SBDG
- Injection 1649574 DF
- Injectable Product 1151126 DFG
Clinical & branded drugs 4

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Piperacillin 4000 MG / tazobactam 500 MG Injection 1659149 SCD
- Piperacillin 4000 MG 1659148 SCDC
- Tazobactam 500 MG 1656793 SCDC
- Piperacillin 4000 MG / tazobactam 500 MG [Zosyn] 1659150 SBDC

Showing up to 8 concepts per family — 14 of 14 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Piperacillin 4000 MG / tazobactam 500 MG Injection SCD · 1659149
Piperacillin 4000 MG SCDC · 1659148
Tazobactam 500 MG SCDC · 1656793
Piperacillin / tazobactam Injection SCDF · 1659130
Piperacillin / tazobactam Injectable Product SCDG · 1159278

Brand-Name Concepts

Piperacillin 4000 MG / tazobactam 500 MG [Zosyn] SBDC · 1659150
Piperacillin / tazobactam Injection [Zosyn] SBDF · 1659133
Zosyn Injectable Product SBDG · 1186325
Zosyn BN · 74170

📦 FDA Products & Package NDCs

6 products · 6 package NDCs

6 package NDCs map to RxCUI 1659151 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00206-8860-02	24 BAG in 1 BOX (0206-8860-02) / 50 mL in 1 BAG (0206-8860-...	Zosyn in Galaxy Containers	Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.	1998-03-01
00206-8861-02	24 BAG in 1 BOX (0206-8861-02) / 50 mL in 1 BAG (0206-8861-...	Zosyn in Galaxy Containers	Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.	1998-03-01
00206-8862-02	12 BAG in 1 BOX (0206-8862-02) / 100 mL in 1 BAG (0206-8862...	Zosyn in Galaxy Containers	Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.	1998-03-01
00338-9632-24	24 BAG in 1 CARTON (0338-9632-24) / 50 mL in 1 BAG (0338-96...	Zosyn	Baxter Healthcare Corporation	2023-04-01
00338-9636-24	24 BAG in 1 CARTON (0338-9636-24) / 50 mL in 1 BAG (0338-96...	Zosyn	Baxter Healthcare Corporation	2023-04-01
00338-9638-12	12 BAG in 1 CARTON (0338-9638-12) / 100 mL in 1 BAG (0338-9...	Zosyn	Baxter Healthcare Corporation	2023-04-01

Observed labelers: Baxter Healthcare Corporation (3) · Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. (3) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🧾 Billing Codes (HCPCS)

Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.

Code	Descriptor	Mapped packages	Sources
J2543	Piperacillin/tazobactam	3	CMS

⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.