J2543
J2543 – Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1. · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 119 NDCs crosswalked per 1.125 GM $1.218/unit ASP+6%
📋 J2543 summary
J2543 is a HCPCS Level II J-code used to bill piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams), billed per 1.125 GM. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J2543: Piperacillin-Tazobactam*, Piperacillin And Tazobactam And Sodium Chloride, Zosyn
Code J2543
Billing unit 1.125 GM Payment limit $1.218/unit NDC-Crosswalk 119
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ2543
DescriptorInjection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
Billing unit1.125 GM
Payment limit / unit$1.218
Est. ASP / unit$1.149 est.
Mapped NDCs119
Data periodQ3 2026
Last updated2026-08-20
💊 About Piperacillin and Tazobactam Injection DRUG GUIDE
Piperacillin and tazobactam injection treats several types of serious bacterial infections in adults and, for some uses, in children 2 months of age and older.
These include intra-abdominal infections (such as appendicitis with rupture or abscess and peritonitis), hospital-acquired pneumonia (nosocomial pneumonia), and community-acquired pneumonia of moderate severity.In adults, it is also used for uncomplicated and complicated skin and skin structure infections — including cellulitis, skin abscesses, and diabetic foot infections — as well as female pelvic infections such as postpartum endometritis and pelvic inflammatory disease.
All uses require that the infection is proven or strongly suspected to be caused by susceptible bacteria.
Clinical overview from our editorial drug guide for Piperacillin and Tazobactam Injection. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$1.218
Est. ASP / unit
$1.149 est.
Est. after 2% sequester
$1.194
HCPCS dosage
1.125 GM
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment group—
Action codeN — No maintenance this year
Effective date2001-01-01
Date added2000-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J2543 = 1.125 gm. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J2543 LEAST EXPENSIVE FIRST
119 NDCs map to J2543. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($1.218/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 00781-3113-95 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-3113... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS ASP |
| 44567-0802-10 | Piperacillin and Tazobactam 3 g/1; .375 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 BOX (44567-802-10) / 1 INJEC... | 3 g/1; .375 g/1 | 30 | $36.54 | $3.493 | ● Active | CMS ASP |
| 55150-0120-30 | Piperacillin and Tazobactam 3 g/1; .375 g/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-120-30) / 1 INJEC... | 3 g/1; .375 g/1 | 30 | $36.54 | $3.493 | ● Active | CMS ASP |
| 60505-6157-04 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Apotex | 10 VIAL, SINGLE-DOSE in 1 CARTON (60505-61... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 63323-0983-21 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-983... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 63323-0983-53 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-983... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 65219-0436-20 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 CARTON (65219-43... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 68001-0507-82 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | BluePoint | 10 VIAL, SINGLE-DOSE in 1 CARTON (68001-50... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 72485-0403-10 | piperacillin and tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Armas | 10 VIAL, SINGLE-DOSE in 1 BOX (72485-403-1... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 72572-0573-10 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Civica, | 10 VIAL, SINGLE-DOSE in 1 CARTON (72572-57... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 81284-0152-10 | PIPERACILLIN AND TAZOBACTAM 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Provepharm | 10 VIAL, SINGLE-DOSE in 1 CARTON (81284-15... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | $3.493 | ● Active | CMS + PDAC |
| 00264-3446-11 | Piperacillin and Tazobactam and Sodium Chloride 250 mg/50mL; 2 g/50mL INJECTION, SOLUTION | B. | 24 CONTAINER in 1 CASE (0264-3446-11) / 5... | 250 mg/50mL; 2 g/50mL | 48 | $58.46 | — | ● Active | CMS ASP |
| 00264-3448-11 | Piperacillin and Tazobactam and Sodium Chloride 375 mg/50mL; 3 g/50mL INJECTION, SOLUTION | B. | 24 CONTAINER in 1 CASE (0264-3448-11) / 5... | 375 mg/50mL; 3 g/50mL | 72 | $87.70 | — | ● Active | CMS ASP |
| 00264-3450-22 | Piperacillin and Tazobactam and Sodium Chloride 500 mg/100mL; 4 g/100mL INJECTION, SOLUTION | B. | 24 CONTAINER in 1 CASE (0264-3450-22) / 1... | 500 mg/100mL; 4 g/100mL | 96 | $116.93 | — | ● Active | CMS ASP |
| 00338-9632-24 | Zosyn piperacillin sodium and tazobactam 2 g/50mL; .25 g/50mL INJECTION, SOLUTION | Baxter | 24 BAG in 1 CARTON (0338-9632-24) / 50 mL... | 2 g/50mL; .25 g/50mL | 48 | $58.46 | — | ● Active | CMS + PDAC |
| 00338-9636-24 | Zosyn piperacillin sodium and tazobactam 3 g/50mL; .375 g/50mL INJECTION, SOLUTION | Baxter | 24 BAG in 1 CARTON (0338-9636-24) / 50 mL... | 3 g/50mL; .375 g/50mL | 72 | $87.70 | — | ● Active | CMS + PDAC |
| 00338-9638-12 | Zosyn piperacillin sodium and tazobactam 4 g/100mL; .5 g/100mL INJECTION, SOLUTION | Baxter | 12 BAG in 1 CARTON (0338-9638-12) / 100 m... | 4 g/100mL; .5 g/100mL | 48 | $58.46 | — | ● Active | CMS + PDAC |
| 00409-2999-14 | Piperacillin and Tazobactam 12 g/60mL; 1.5 g/60mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Hospira, | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 12 g/60mL; 1.5 g/60mL | 12 | $14.62 | — | ● Active | CMS + PDAC |
| 00409-3374-02 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 20 | $24.36 | — | — | CMS ASP |
| 00409-3378-13 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 30 | $36.54 | — | — | CMS ASP |
| 00409-3379-04 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 40 | $48.72 | — | — | CMS ASP |
| 00409-3383-02 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 20 | $24.36 | — | — | CMS ASP |
| 00409-3383-10 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Hospira, | 10 VIAL, SINGLE-USE in 1 CARTON (0409-3383... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 00409-3385-13 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 30 | $36.54 | — | — | CMS ASP |
| 00409-3385-15 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Hospira, | 10 VIAL, SINGLE-USE in 1 CARTON (0409-3385... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | — | ● Active | CMS + PDAC |
| 00409-3390-04 | Piperacillin Sodium-Tazobactam Sodium | Pfizer | — | — | 40 | $48.72 | — | — | CMS ASP |
| 00409-3390-10 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Hospira, | 10 VIAL, SINGLE-USE in 1 CARTON (0409-3390... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 00781-3110-95 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-3110... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS ASP |
| 00781-3114-95 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-3114... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS ASP |
| 00781-3180-94 | Piperacillin and Tazobactam 36 g/250mL; 4.5 g/250mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/250mL; 4.5 g/250mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 00781-9210-95 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-9210... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | Obsolete | CMS + PDAC |
| 00781-9213-95 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-9213... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | — | Obsolete | CMS + PDAC |
| 00781-9214-95 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sandoz | 10 VIAL, SINGLE-USE in 1 CARTON (0781-9214... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | Obsolete | CMS + PDAC |
| 25021-0164-30 | Piperacillin Sodium-Tazobactam Sodium | Sagent | — | — | 20 | $24.36 | — | — | CMS ASP |
| 25021-0165-30 | Piperacillin Sodium-Tazobactam Sodium | Sagent | — | — | 30 | $36.54 | — | — | CMS ASP |
| 25021-0166-48 | Piperacillin Sodium-Tazobactam Sodium | Sagent | — | — | 40 | $48.72 | — | — | CMS ASP |
| 25021-0181-99 | Piperacillin, Tazobactam 36 g/152mL; 4.5 g/152mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Sagent | 1 BOTTLE in 1 CARTON (25021-181-99) / 152... | 36 g/152mL; 4.5 g/152mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 44567-0801-10 | Piperacillin and Tazobactam 2 g/1; .25 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 BOX (44567-801-10) / 1 INJEC... | 2 g/1; .25 g/1 | 20 | $24.36 | — | ● Active | CMS ASP |
| 44567-0803-10 | Piperacillin and Tazobactam 4 g/1; .5 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 BOX (44567-803-10) / 1 INJEC... | 4 g/1; .5 g/1 | 40 | $48.72 | — | ● Active | CMS ASP |
| 44567-0804-01 | Piperacillin and Tazobactam 36 g/1; 4.5 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/1; 4.5 g/1 | 36 | $43.85 | — | ● Active | CMS ASP |
| 55150-0119-30 | Piperacillin and Tazobactam 2 g/1; .25 g/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-119-30) / 1 INJEC... | 2 g/1; .25 g/1 | 20 | $24.36 | — | ● Active | CMS ASP |
| 55150-0121-50 | Piperacillin and Tazobactam 4 g/1; .5 g/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-121-50) / 1 INJEC... | 4 g/1; .5 g/1 | 40 | $48.72 | — | ● Active | CMS ASP |
| 60505-6156-04 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, FOR SOLUTION | Apotex | 10 VIAL, SINGLE-DOSE in 1 CARTON (60505-61... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 60505-6159-04 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | Apotex | 10 VIAL, SINGLE-DOSE in 1 CARTON (60505-61... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 60505-6262-00 | Piperacillin and Tazobactam 4.5 g/180mL; 36 g/180mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Apotex | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 4.5 g/180mL; 36 g/180mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 61990-0110-02 | Piperacillin Sodium-Tazobactam Sodium | Apollo | — | — | 20 | $24.36 | — | — | CMS + PDAC |
| 61990-0120-02 | Piperacillin Sodium-Tazobactam Sodium | Apollo | — | — | 30 | $36.54 | — | — | CMS + PDAC |
| 61990-0130-02 | Piperacillin Sodium-Tazobactam Sodium | Apollo | — | — | 40 | $48.72 | — | — | CMS + PDAC |
| 61990-0150-01 | Piperacillin Sodium-Tazobactam Sodium | Apollo | — | — | 36 | $43.85 | — | — | CMS + PDAC |
| 63323-0981-21 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-981... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 63323-0981-53 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-981... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 65219-0256-00 | Piperacillin and Tazobactam 36 g/180mL; 4.5 g/180mL INJECTION, POWDER, FOR SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/180mL; 4.5 g/180mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 65219-0256-24 | Piperacillin and Tazobactam 36 g/180mL; 4.5 g/180mL INJECTION, POWDER, FOR SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/180mL; 4.5 g/180mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 65219-0256-28 | Piperacillin and Tazobactam 36 g/180mL; 4.5 g/180mL INJECTION, POWDER, FOR SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/180mL; 4.5 g/180mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 65219-0259-45 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (65219-259... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 65219-0259-55 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (65219-259... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 65219-0434-20 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 CARTON (65219-43... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 66794-0216-41 | Piperacillin Sodium-Tazobactam Sodium | Piramal | — | — | 20 | $24.36 | — | — | CMS + PDAC |
| 66794-0217-41 | Piperacillin Sodium-Tazobactam Sodium | Piramal | — | — | 30 | $36.54 | — | — | CMS + PDAC |
| 66794-0218-41 | Piperacillin Sodium-Tazobactam Sodium | Piramal | — | — | 40 | $48.72 | — | — | CMS + PDAC |
| 68001-0506-30 | Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL INJECTION, POWDER, FOR SOLUTION | BluePoint | 10 VIAL, SINGLE-DOSE in 1 CARTON (68001-50... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS + PDAC |
| 68001-0508-31 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | BluePoint | 10 VIAL, SINGLE-DOSE in 1 CARTON (68001-50... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 70860-0120-20 | Piperacillin Sodium-Tazobactam Sodium | Athenex | — | — | 20 | $24.36 | — | — | CMS + PDAC |
| 70860-0121-30 | Piperacillin Sodium-Tazobactam Sodium | Athenex | — | — | 30 | $36.54 | — | — | CMS + PDAC |
| 70860-0122-50 | Piperacillin Sodium-Tazobactam Sodium | Athenex | — | — | 40 | $48.72 | — | — | CMS + PDAC |
| 70860-0123-99 | Piperacillin Sodium-Tazobactam Sodium | Athenex | — | — | 36 | $43.85 | — | — | CMS + PDAC |
| 72485-0404-10 | piperacillin and tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | Armas | 10 VIAL, SINGLE-DOSE in 1 BOX (72485-404-1... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 72572-0414-10 | piperacillin and tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Civica, | 10 VIAL, SINGLE-USE in 1 CARTON (72572-414... | 3 g/15mL; .375 g/15mL | 30 | $36.54 | — | ● Active | CMS + PDAC |
| 72572-0418-10 | piperacillin and tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | Civica, | 10 VIAL, SINGLE-USE in 1 CARTON (72572-418... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 72572-0574-10 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | Civica, | 10 VIAL, SINGLE-DOSE in 1 CARTON (72572-57... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 81284-0151-10 | PIPERACILLIN AND TAZOBACTAM 2 g/10mL; .25 g/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Provepharm | 10 VIAL, SINGLE-DOSE in 1 CARTON (81284-15... | 2 g/10mL; .25 g/10mL | 20 | $24.36 | — | ● Active | CMS ASP |
| 81284-0153-10 | PIPERACILLIN AND TAZOBACTAM 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Provepharm | 10 VIAL, SINGLE-DOSE in 1 CARTON (81284-15... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 81284-0154-01 | Piperacillin and Tazobactam 12 g/60mL; 1.5 g/60mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Provepharm | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 12 g/60mL; 1.5 g/60mL | 12 | $14.62 | — | ● Active | CMS ASP |
| 81284-0155-01 | Piperacillin and Tazobactam 36 g/180mL; 4.5 g/180mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Provepharm | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 36 g/180mL; 4.5 g/180mL | 36 | $43.85 | — | ● Active | CMS + PDAC |
| 83634-0106-50 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, FOR SOLUTION | Avenacy, | 10 VIAL, SINGLE-DOSE in 1 CARTON (83634-10... | 4 g/20mL; .5 g/20mL | 40 | $48.72 | — | ● Active | CMS + PDAC |
| 83634-0105-30 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Avenacy, | 10 VIAL, SINGLE-DOSE in 1 CARTON (83634-10... | 3 g/15mL; .375 g/15mL | 3 | $3.65 | — | ● Active | PDAC |
| 25021-0175-20 | PIPERACILLIN AND TAZOBACTAM (SDV,PF,LATEX-FREE) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 25021-0177-50 | PIPERACILLIN AND TAZOBACTAM (SDV,PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 25021-0176-20 | PIPERACILLIN AND TAZOBACTAM (SDV,PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 70594-0078-02 | PIPERACILLIN AND TAZOBACTAM (SDV;USP,PF,LATEX-FREE) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 70594-0079-02 | PIPERACILLIN AND TAZOBACTAM (SDV;USP,PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 70594-0080-02 | PIPERACILLIN AND TAZOBACTAM (SDV;USP,PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 60505-6156-00 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 60505-6157-00 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 60505-6159-00 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 64679-0679-01 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 36 GM-4.5 GM | Unknown | — | — | 36 | $43.85 | — | — | PDAC |
| 64679-0012-01 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 64679-0034-01 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 64679-0056-01 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 72572-0577-10 | PIPERACILLIN AND TAZOBACTAM (SDV;USP,PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 72572-0576-10 | PIPERACILLIN AND TAZOBACTAM (SDV;USP,PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 63323-0982-54 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-982... | 4 g/20mL; .5 g/20mL | 4 | $4.87 | — | ● Active | PDAC |
| 71288-0002-31 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 71288-0003-31 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 71288-0004-51 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 61990-0110-01 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 61990-0140-01 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 12 GM-1.5 GM | Unknown | — | — | 12 | $14.62 | — | — | PDAC |
| 61990-0130-01 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 61990-0120-01 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 63323-0982-52 | Piperacillin and Tazobactam 4 g/20mL; .5 g/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL, SINGLE-USE in 1 CARTON (63323-982... | 4 g/20mL; .5 g/20mL | 4 | $4.87 | — | ● Active | PDAC |
| 39822-0123-02 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 39822-0125-04 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 39822-0127-06 | PIPERACILLIN AND TAZOBACTAM (PF,LATEX-FREE) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 39822-0139-07 | PIPERACILLIN AND TAZOBACTAM (PHARMACY BULK PACKAGE) 36 GM-4.5 GM | Unknown | — | — | 36 | $43.85 | — | — | PDAC |
| 67457-0521-22 | PIPERACILLIN AND TAZOBACTAM (SINGLE DOSE,PF) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 67457-0523-45 | PIPERACILLIN AND TAZOBACTAM (SINGLE USE,PF) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 00781-3367-95 | PIPERACILLIN AND TAZOBACTAM (SINGLE USE,PF) 4 GM-0.5 GM | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 00781-3344-95 | PIPERACILLIN AND TAZOBACTAM (SINGLE USE,PF) 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 60505-0687-01 | PIPERACILLIN AND TAZOBACTAM (SDV) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 63323-0300-30 | Piperacillin and Tazobactam 3 g/15mL; .375 g/15mL INJECTION, POWDER, FOR SOLUTION | Fresenius | 10 VIAL in 1 BOX (63323-300-30) / 15 mL i... | 3 g/15mL; .375 g/15mL | 3 | $3.65 | — | ● Active | PDAC |
| 60505-0687-04 | PIPERACILLIN AND TAZOBACTAM (SDV) 3 GM-0.375 GM | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 60505-0773-00 | PIPERACILLIN AND TAZOBACTAM (PHARMACY BULK PACKAGE) 36 GM-4.5 GM | Unknown | — | — | 36 | $43.85 | — | — | PDAC |
| 00206-8859-10 | ZOSYN (PHARMACY BULK VIAL) 36 GM-4.5 GM | Unknown | — | — | 36 | $43.85 | — | — | PDAC |
| 00206-8852-16 | ZOSYN 2 GM-0.25 GM | Unknown | — | — | 2 | $2.44 | — | — | PDAC |
| 00206-8855-16 | ZOSYN (SDV,10X100ML) 4 GM/100 ML-0.5 GM/100 ML | Unknown | — | — | 4 | $4.87 | — | — | PDAC |
| 00206-8854-16 | ZOSYN (SDV,10X50ML) 3 GM/50 ML-0.375 GM/50 ML | Unknown | — | — | 3 | $3.65 | — | — | PDAC |
| 00206-8862-02 | Zosyn in Galaxy Containers TAZOBACTAM SODIUM and PIPERACILLIN 500 mg/100mL; 4 g/100mL INJECTION, SOLUTION | Wyeth | 12 BAG in 1 BOX (0206-8862-02) / 100 mL i... | 500 mg/100mL; 4 g/100mL | 0.04 | $0.05 | — | Obsolete | PDAC |
| 00206-8861-02 | Zosyn in Galaxy Containers TAZOBACTAM SODIUM and PIPERACILLIN 375 mg/50mL; 3 g/50mL INJECTION, SOLUTION | Wyeth | 24 BAG in 1 BOX (0206-8861-02) / 50 mL in... | 375 mg/50mL; 3 g/50mL | 0.06 | $0.07 | — | Obsolete | PDAC |
| 00206-8860-02 | Zosyn in Galaxy Containers TAZOBACTAM SODIUM and PIPERACILLIN 250 mg/50mL; 2 g/50mL INJECTION, SOLUTION | Wyeth | 24 BAG in 1 BOX (0206-8860-02) / 50 mL in... | 250 mg/50mL; 2 g/50mL | 0.04 | $0.05 | — | Obsolete | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$14.7K
Claims
873
Beneficiaries
285
Spend / beneficiary
$51.47
Spend / claim
$16.80
Trend by period
Where J2543 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #670 of 824
#665
HYPERTET J1670
$16.9K
#666
VANCOMYCIN HCL-0.9%... J3373
$16K
#667
PERSERIS J2798
$15.2K
#668
RUCONEST J0596
$15.2K
#669
ACYCLOVIR SODIUM J0133
$14.7K
#670
PIPERACILLIN-TAZOBAC... J2543
$14.7K
#671
MULTIHANCE MULTIPACK A9578
$13.7K
#672
FLUDARABINE PHOSPHAT... J9185
$13.6K
#673
MICAFUNGIN(J2248)* J2248
$13.4K
#674
CORTROSYN* J0834
$13.2K
#675
IMIPENEM-CILASTATIN... J0743
$13.1K
Total claims — #388 of 824
#383
CABENUVA J0741
920
#384
ORPHENADRINE CITRATE J2360
916
#385
PEMRYDI RTU J9324
903
#386
ENJAYMO J1302
892
#387
ASTAGRAF XL J7508
883
#388
PIPERACILLIN-TAZOBAC... J2543
873
#389
AMIKACIN SULFATE J0278
865
#390
LUMASON Q9950
846
#391
RELESE, PER SQ CM** Q4257
843
#392
LEUPROLIDE DEPOT* J1954
839
#393
VYLOY J1326
834
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $14.7K | 285 | 873 | $51.47 | $16.80 |
| 2025 (Q1-Q4) | $62.6K | 1,170 | 4,056 | $53.51 | $15.44 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$55.9K
Medicare paid
$43.8K
Submitted services
250,610
Denial rate
79.7%
Allowed / service
$1.10
Submitted charges
$3.69M
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
🗺️ Where J2543 is utilized CMS · BY PROVIDER · 2024
Medicare Part B services for this code by the rendering provider's state — 9,655 services across 6 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.
Hover or tap a state to see its numbers + top ZIP codes.
Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.
📊 What bills under J2543
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
119 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J2543 billing FAQ
What is HCPCS code J2543?
J2543 is a HCPCS Level II J-code used to bill Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams) under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2543?
One unit of J2543 represents 1.125 GM. Report the number of units equal to the dose administered divided by 1.125 GM.
How many units of J2543 should I bill?
Divide the dose administered by the code's unit size (1.125 GM) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2543?
The Medicare Part B payment limit is $1.218 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $1.194 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2543?
119 NDCs currently map to J2543 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2543 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.