J2151 NDC Crosswalk, Billing Units, ASP Payment & Medicare Reimbursement

📋 J2151 summary

J2151 is a HCPCS Level II J-code used to bill mannitol, 250 mg, billed per 250 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Brand names associated with J2151: Mannitol(J2151), Osmitrol

Code J2151 Billing unit 250 MG Payment limit $0.071/unit NDC-Crosswalk 11 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ2151

DescriptorInj, mannitol, 250 mg

Billing unit250 MG

Payment limit / unit$0.071

Est. ASP / unit$0.067 est.

Mapped NDCs11

Data periodQ3 2026

Last updated2026-08-20

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).

Medicare payment limit / unit

$0.071

Est. ASP / unit

$0.067 est.

Est. after 2% sequester

$0.070

HCPCS dosage

250 MG

The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J2151 = 250 mg. Enter a regimen to convert dose → billing units and project a full course.

Dose per administration (mg) Frequency — every days Number of doses NDC / package billed (optional)

Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J2151 WITH EST. MEDICARE PAY

11 NDCs map to J2151. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.071/unit) × that package's bill units.

NDC (11-digit)	Drug	Labeler	Package	Strength	Bill units	Est. pay / pkg	NADAC / unit	Status	Source
00404-9905-50	Mannitol 12.5 g/50mL INJECTION, SOLUTION	Henry	1 VIAL, SINGLE-DOSE in 1 BAG (0404-9905-50...	12.5 g/50mL	50	$3.55	—	● Active	CMS ASP
00409-4031-01	Mannitol 12.5 g/50mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-4031-...	12.5 g/50mL	1,250	$88.75	—	● Active	CMS + PDAC
00990-7715-02	Mannitol 20 g/100mL INJECTION, SOLUTION	ICU	24 POUCH in 1 CASE (0990-7715-02) / 1 BAG...	20 g/100mL	4,800	$340.80	—	● Active	CMS + PDAC
00990-7715-03	Mannitol 20 g/100mL INJECTION, SOLUTION	ICU	12 POUCH in 1 CASE (0990-7715-03) / 1 BAG...	20 g/100mL	4,800	$340.80	—	● Active	CMS + PDAC
51662-1468-01	MANNITOL 12.5 g/50mL INJECTION, SOLUTION	HF	50 mL in 1 VIAL, SINGLE-DOSE (51662-1468-1...	12.5 g/50mL	50	$3.55	—	● Active	CMS ASP
51662-1468-03	MANNITOL 12.5 g/50mL INJECTION, SOLUTION	HF	25 POUCH in 1 CASE (51662-1468-3) / 1 VIA...	12.5 g/50mL	1,250	$88.75	—	● Active	CMS ASP
63323-0024-25	Mannitol 250 mg/mL INJECTION, SOLUTION	Fresenius	25 VIAL, SINGLE-DOSE in 1 TRAY (63323-024-...	250 mg/mL	50	$3.55	—	● Active	CMS + PDAC
00264-7578-10	Mannitol 20 g/100mL INJECTION, SOLUTION	B.	24 CONTAINER in 1 CASE (0264-7578-10) / 5...	20 g/100mL	0.8	$0.06	—	● Active	PDAC
00338-0353-03	Osmitrol Mannitol 10 g/100mL INJECTION, SOLUTION	Baxter	500 mL in 1 BAG (0338-0353-03)	10 g/100mL	0.4	$0.03	—	● Active	PDAC
00338-0357-02	Osmitrol Mannitol 20 g/100mL INJECTION, SOLUTION	Baxter	250 mL in 1 BAG (0338-0357-02)	20 g/100mL	0.8	$0.06	—	● Active	PDAC
00338-0357-03	Osmitrol Mannitol 20 g/100mL INJECTION, SOLUTION	Baxter	500 mL in 1 BAG (0338-0357-03)	20 g/100mL	0.8	$0.06	—	● Active	PDAC

NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

⚠️ Don't confuse J2151 with… RELATED CODES

Adjacent HCPCS codes that share an ingredient or formulation with J2151. Billing units and payment limits differ — confirm the exact code, strength and form before billing.

Code	Descriptor	Billing unit	Payment limit / unit	How it differs from J2151
J2150	Mannitol injection	—	—	Related ingredient or formulation — confirm strength, form and billing unit before substituting.

Related codes matched on shared ingredient (CMS Medicare Part B Spending feed). Billing units and payment limits from the CMS ASP Pricing File. Always verify the precise HCPCS code for the product and strength administered.

📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)

Period

Total Part B spend

$2.8K

Claims

925

Beneficiaries

281

Spend / beneficiary

$9.98

Spend / claim

$3.03

Trend by period

Where J2151 ranks among Part B drugs · 2026 (Q1) · neighbors ±5

Total spending — #734 of 824

#729 HALDOL DECANOATE 100... J1631 $3.1K #730 GEMCITABINE HCL(J919... J9196 $3K #731 PAMIDRONATE DISODIUM J2430 $3K #732 LEVOFLOXACIN-D5W J1956 $2.9K #733 CLEOCIN PHOSPHATE* J0736 $2.8K #734 MANNITOL(J2151) J2151 $2.8K #735 CHLOROTHIAZIDE SODIU... J1205 $2.7K #736 AZMIRO J1072 $2.7K #737 DIPYRIDAMOLE J1245 $2.6K #738 PROCHLORPERAZINE EDI... J0780 $2.5K #739 PREDNISOLONE SODIUM... J7510 $2.4K

Total claims — #381 of 824

#376 POTELIGEO J9204 976 #377 LANREOTIDE ACETATE(J... J1932 970 #378 APRETUDE J0739 959 #379 OASIS ULTRA Q4124 939 #380 BLINCYTO J9039 933 #381 MANNITOL(J2151) J2151 925 #382 BEOVU J0179 920 #383 CABENUVA J0741 920 #384 ORPHENADRINE CITRATE J2360 916 #385 PEMRYDI RTU J9324 903 #386 ENJAYMO J1302 892

Full breakdown by period (2)

Period	Total spend	Beneficiaries	Claims	$/beneficiary	$/claim
2026 (Q1)	$2.8K	281	925	$9.98	$3.03
2025 (Q1-Q4)	$2.2K	258	894	$8.41	$2.43

Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.

Allowed charges

$2.2K

Medicare paid

$1.7K

Submitted services

39,475

Denial rate

7.4%

Allowed / service

$0.06

Submitted charges

$135.8K

Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

📊 What bills under J2151

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient

MANNITOL 4

Mannitol 2

NDC products by labeler

Baxter Healthcare Company 2

B. Braun Medical Inc. 1

Hospira, Inc. 1

ICU Medical Inc. 1

Fresenius Kabi USA, LLC 1

🔗 Related NDC directory pages

🧪 All Mannitol NDCsIngredient 🧪 All Mannitol NDCsIngredient 🏭 All Baxter labeler NDCsLabeler 00338 🏭 All B. labeler NDCsLabeler 00264 🏭 All Hospira, labeler NDCsLabeler 00409 🏭 All ICU labeler NDCsLabeler 00990 📚 All Osmotic Diuretic NDCsDrug class

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.

HCPCS code & descriptor

CMS HCPCS Level II code file

Not available in current dataset

Payment limit & billing unit

CMS Medicare Part B ASP Pricing File (quarterly)

Q3 2026 · as of 2026-08-20

NDC ↔ HCPCS crosswalk

CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)

11 NDCs mapped

NADAC acquisition cost

CMS National Average Drug Acquisition Cost (weekly)

Not available for mapped NDCs

Utilization & spend

CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners

Latest data year 2026

Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J2151 billing FAQ

What is HCPCS code J2151?

J2151 is a HCPCS Level II J-code used to bill Inj, mannitol, 250 mg under Medicare Part B and most medical (not pharmacy) benefits.

What is the billing unit for J2151?

One unit of J2151 represents 250 MG. Report the number of units equal to the dose administered divided by 250 MG.

How many units of J2151 should I bill?

Divide the dose administered by the code's unit size (250 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.

How much does Medicare pay for J2151?

The Medicare Part B payment limit is $0.071 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.070 per unit. Payment limits are revised quarterly.

Which NDCs bill under J2151?

11 NDCs currently map to J2151 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.

Does a crosswalk mean J2151 is covered?

No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.

J2151 – Inj, mannitol, 250 mg · NDC Crosswalk & Billing Units