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Acetaminophen 25 MG/ML / dextromethorphan hydrobromide 1.33 MG/ML / guaifenesin 20 MG/ML /... — RxCUI 1790651

Name: Acetaminophen 25 MG/ML / dextromethorphan hydrobromide 1.33 MG/ML / guaifenesin 20 MG… (RxCUI 1790651)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 1790651 Semantic clinical drug · SCD ● Current RxNorm concept 8 FDA products 8 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1790651

Official nameAcetaminophen 25 MG/ML / dextromethorphan hydrobromide 1.33 MG/ML / guaifenesin 20 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asacetaminophen 250 MG / dextromethorphan HBr 13.33 MG / guaifenesin 200 MG / phenylephrine HCl 5 MG per 10 ML Oral Solution; acetaminophen 250 MG / dextromethorphan HBr 13.33 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG in 10 mL Oral Solution; acetaminophen 500 MG / dextromethorphan HBr 26.66 MG / guaifenesin 400 MG / phenylephrine HCl 10 MG per 20 ML Oral Solution; APAP 25 MG/ML / Dextromethorphan Hydrobromide 1.33 MG/ML / Guaifenesin 20 MG/ML / Phenylephrine Hydrochloride 0.5 MG/ML Oral Solution

FDA products mapped8

Package NDCs mapped8

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
Can I use the nasal spray if I have high blood pressure or heart disease?

📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 25 MG/ML / dextromethorphan hydrob... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 25 MG/ML / dextromethorphan hydrobromide 1.33 MG/ML / guaifenesin 20 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution RxCUI 1790651 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 7

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Dextromethorphan 3289 IN
- Guaifenesin 5032 IN
- Phenylephrine 8163 IN
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine 689776 MIN
- Dextromethorphan hydrobromide 102490 PIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Solution 647321 SCDF
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Solution 2648619 SCDFP
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Liquid Product 1155904 SCDG
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Product 1155905 SCDG
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Liquid Product 2660160 SCDGP
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Product 2662312 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 4

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 25 MG/ML 315258 SCDC
- Dextromethorphan hydrobromide 1.33 MG/ML 1246337 SCDC
- Guaifenesin 20 MG/ML 316011 SCDC
- Phenylephrine hydrochloride 0.5 MG/ML 707273 SCDC

Showing up to 8 concepts per family — 19 of 20 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 25 MG/ML SCDC · 315258
Dextromethorphan hydrobromide 1.33 MG/ML SCDC · 1246337
Guaifenesin 20 MG/ML SCDC · 316011
Phenylephrine hydrochloride 0.5 MG/ML SCDC · 707273
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Solution SCDF · 647321
Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Solution SCDFP · 2648619
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Liquid Product SCDG · 1155904
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Product SCDG · 1155905
Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Liquid Product SCDGP · 2660160
Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Product SCDGP · 2662312

📦 FDA Products & Package NDCs

8 products · 8 package NDCs

8 package NDCs map to RxCUI 1790651 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
69729-0051-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-051-06) / 177 mL in 1...	Tenalif Multi Symptom Relief	OPMX LLC	2023-09-18
69729-0070-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-070-06) / 177 mL in 1...	Tenalif Children	OPMX LLC	2023-09-18
69729-0784-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-784-06) / 177 mL in 1...	Rompe Tos X Children	OPMX LLC	2023-09-18
69729-0785-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-785-06) / 177 mL in 1...	Rompe Tos X Adults	OPMX LLC	2023-09-18
69729-0786-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-786-06) / 177 mL in 1...	Tesalon Children	OPMX LLC	2024-09-27
69729-0787-06	1 BOTTLE, PLASTIC in 1 CARTON (69729-787-06) / 177 mL in 1...	Tesalon Jarabe Adulto	OPMX LLC	2024-09-27
69729-0789-06	1 BOTTLE in 1 CARTON (69729-789-06) / 177 mL in 1 BOTTLE	Pentrexcilina Children TOTAL RELIEF Multi-Symptom	OPMX LLC	2025-01-15
69729-0790-06	1 BOTTLE in 1 CARTON (69729-790-06) / 177 mL in 1 BOTTLE	Pentrexcilina Adult TOTAL RELIEF Multi-Symptom	OPMX LLC	2025-01-15

Observed labelers: OPMX LLC (8) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.