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Hydrochlorothiazide 25 MG / spironolactone 25 MG Oral Tablet — RxCUI 198224

RxNorm drug concept · Semantic clinical drug
RxCUI 198224 Semantic clinical drug · SCD ● Current RxNorm concept 11 FDA products 23 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI198224
Official nameHydrochlorothiazide 25 MG / spironolactone 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asHCTZ 25 MG / spironolactone 25 MG Oral Tablet
FDA products mapped11
Package NDCs mapped23
Reported Medicaid activity (SDUD)24,202 prescriptions · 43 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Spironolactone and Hydrochlorothiazide: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Great question. Spironolactone and hydrochlorothiazide are two different diuretics (water pills) that work in different parts of the kidney. Together, they remove excess fluid and...
  • Usually no — and this is really important. Spironolactone already protects your potassium, so adding extra potassium through supplements, salt substitutes, or a very high-potassium...
  • Should I be taking a potassium supplement with this?
  • Common things you might notice include dizziness when you stand up quickly, some nausea or stomach upset, headache, or muscle cramps — those are generally manageable. Men sometimes...
📖 Read our full Spironolactone and Hydrochlorothiazide guide →

🕸️ Concept Web — How Hydrochlorothiazide 25 MG / spironolactone 25 MG... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Hydrochlorothiazide 25 MG / spironolactone 25 MG Oral Tablet RxCUI 198224

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 3

    The active substance itself — no strength, form, or brand attached yet.

    • Hydrochlorothiazide 5487
    • Spironolactone 9997
    • Hydrochlorothiazide / spironolactone 324042
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Aldactazide 17276
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Hydrochlorothiazide / spironolactone Oral Tablet 370639
    • Hydrochlorothiazide / spironolactone Oral Product 1162146
    • Hydrochlorothiazide / spironolactone Pill 1162147
    • Hydrochlorothiazide / spironolactone Oral Tablet [Aldactazide] 369279
    • Aldactazide Oral Product 1174846
    • Aldactazide Pill 1174847
    • Oral Tablet 317541
    • Oral Product 1151131
    • +1 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Hydrochlorothiazide 25 MG 316049
    • Spironolactone 25 MG 316728
    • Hydrochlorothiazide 25 MG / spironolactone 25 MG Oral Tablet [Aldactazide] 208112
    • Hydrochlorothiazide 25 MG / spironolactone 25 MG [Aldactazide] 568840

Showing up to 8 concepts per family — 16 of 17 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Hydrochlorothiazide 25 MG SCDC · 316049
  • Spironolactone 25 MG SCDC · 316728
  • Hydrochlorothiazide / spironolactone Oral Tablet SCDF · 370639
  • Hydrochlorothiazide / spironolactone Oral Product SCDG · 1162146
  • Hydrochlorothiazide / spironolactone Pill SCDG · 1162147

Brand-Name Concepts

  • Hydrochlorothiazide 25 MG / spironolactone 25 MG Oral Tablet [Aldactazide] SBD · 208112
  • Hydrochlorothiazide 25 MG / spironolactone 25 MG [Aldactazide] SBDC · 568840
  • Hydrochlorothiazide / spironolactone Oral Tablet [Aldactazide] SBDF · 369279
  • Aldactazide Oral Product SBDG · 1174846
  • Aldactazide Pill SBDG · 1174847
  • Aldactazide BN · 17276

📦 FDA Products & Package NDCs

11 products · 23 package NDCs
23 package NDCs map to RxCUI 198224 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00378-0403-01 100 TABLET in 1 BOTTLE, PLASTIC (0378-0403-01) Spironolactone and Hydrochlorothiazide Mylan Pharmaceuticals Inc. 1979-08-03
00378-0403-05 500 TABLET in 1 BOTTLE, PLASTIC (0378-0403-05) Spironolactone and Hydrochlorothiazide Mylan Pharmaceuticals Inc. 1979-08-03
42292-0017-20 100 BLISTER PACK in 1 CARTON (42292-017-20) / 1 TABLET in 1... Spironolactone and Hydrochlorothiazide Mylan Institutional Inc. 2017-05-12
48433-0090-20 100 BLISTER PACK in 1 CARTON (48433-090-20) / 1 TABLET in 1... Spironolactone and Hydrochlorothiazide Safecor Health LLC 2026-05-05
53489-0144-01 100 TABLET in 1 BOTTLE, PLASTIC (53489-144-01) Spironolactone and Hydrochlorothiazide Sun Pharmaceutical Industries, Inc. 1987-07-02
53489-0144-05 500 TABLET in 1 BOTTLE, PLASTIC (53489-144-05) Spironolactone and Hydrochlorothiazide Sun Pharmaceutical Industries, Inc. 1987-07-02
53489-0144-10 1000 TABLET in 1 BOTTLE, PLASTIC (53489-144-10) Spironolactone and Hydrochlorothiazide Sun Pharmaceutical Industries, Inc. 1987-07-02
63629-1068-01 100 TABLET in 1 BOTTLE, PLASTIC (63629-1068-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 1987-07-02
63629-1069-01 500 TABLET in 1 BOTTLE, PLASTIC (63629-1069-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 1987-07-02
63629-1071-01 30 TABLET in 1 BOTTLE, PLASTIC (63629-1071-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2020-09-15
63629-1071-02 60 TABLET in 1 BOTTLE, PLASTIC (63629-1071-2) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2020-09-24
63629-1071-03 1000 TABLET in 1 BOTTLE, PLASTIC (63629-1071-3) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2020-09-21
66993-0188-02 100 TABLET, FILM COATED in 1 BOTTLE (66993-188-02) Spironolactone and Hydrochlorothiazide Prasco Laboratories 2021-11-29
71335-2202-01 100 TABLET in 1 BOTTLE, PLASTIC (71335-2202-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2023-08-04
71335-2674-01 100 TABLET in 1 BOTTLE (71335-2674-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2025-06-26
71335-2674-02 30 TABLET in 1 BOTTLE (71335-2674-2) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2025-06-26
71335-2674-03 60 TABLET in 1 BOTTLE (71335-2674-3) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2025-06-26
72162-1625-00 1000 TABLET in 1 BOTTLE, PLASTIC (72162-1625-0) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
72162-1625-01 100 TABLET in 1 BOTTLE, PLASTIC (72162-1625-1) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
72162-1625-03 30 TABLET in 1 BOTTLE, PLASTIC (72162-1625-3) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
72162-1625-04 1000 TABLET in 1 BOTTLE, PLASTIC (72162-1625-4) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
72162-1625-05 500 TABLET in 1 BOTTLE, PLASTIC (72162-1625-5) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
72162-1625-06 60 TABLET in 1 BOTTLE, PLASTIC (72162-1625-6) Spironolactone and Hydrochlorothiazide Bryant Ranch Prepack 2024-08-05
Observed labelers: Bryant Ranch Prepack (15) · Sun Pharmaceutical Industries, Inc. (3) · Mylan Pharmaceuticals Inc. (2) · Mylan Institutional Inc. (1) · Prasco Laboratories (1) · Safecor Health LLC (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.