Home › NDC Lookup › RxCUI directory › RxCUI 283219

Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo — RxCUI 283219

RxNorm drug concept · Semantic clinical drug
RxCUI 283219 Semantic clinical drug · SCD ● Current RxNorm concept 38 FDA products 46 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI283219
Official namePiperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known aspiperonyl butoxide 4 % / pyrethrins 0.33 % Medicated Shampoo
FDA products mapped38
Package NDCs mapped46
Reported Medicaid activity (SDUD)5,855 prescriptions · 23 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Pyrethrin and Piperonyl Butoxide Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It treats lice — specifically head lice, pubic (sometimes called crab) lice, and body lice. You apply it directly to the affected area of skin or hair, not take it by mouth. It's n...
  • You leave it on for exactly 10 minutes — no longer — then wash it off with warm water and soap or shampoo. And yes, the second treatment 7 to 10 days later is really important. It...
  • How long do I leave it on, and do I really need a second treatment?
  • Combing is a key part of the treatment. After rinsing, towel-dry your hair and use a fine-tooth lice comb while the hair is still slightly damp. Work through sections starting at t...
📖 Read our full Pyrethrin and Piperonyl Butoxide Topical guide →

🕸️ Concept Web — How Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo RxCUI 283219

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 3

    The active substance itself — no strength, form, or brand attached yet.

    • Piperonyl butoxide 8345
    • Pyrethrins 8991
    • Piperonyl butoxide / pyrethrins 91299
  2. Brand names 3

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Herklin 1988405
    • Pronto Plus 729770
    • RID 35607
  3. Dose forms 10

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Piperonyl butoxide / pyrethrins Medicated Shampoo 377511
    • Piperonyl butoxide / pyrethrins Shampoo Product 1295306
    • Piperonyl butoxide / pyrethrins Medicated Shampoo [Herklin] 1988407
    • Piperonyl butoxide / pyrethrins Medicated Shampoo [Pronto Plus] 729772
    • Piperonyl butoxide / pyrethrins Medicated Shampoo [RID] 362502
    • Herklin Shampoo Product 1988408
    • Pronto Plus Shampoo Product 1296259
    • RID Shampoo Product 1296319
    • +2 more in this family
  4. Clinical & branded drugs 8

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Piperonyl butoxide 40 MG/ML 330135
    • Pyrethrins 3.3 MG/ML 333696
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [Herklin] 1988409
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [Pronto Plus] 729773
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [RID] 864131
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [Herklin] 1988406
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [Pronto Plus] 729771
    • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [RID] 864130
  5. Packs 2

    Fixed collections of drugs packaged and sold together, like dose packs.

    • {1 (60 ML) (benzalkonium chloride 1 MG/ML Topical Solution [Pronto Plus Lice Egg Remover]) / 1 (60 ML) (piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [Pronto Plus]) } Pack [Pronto Plus Complete Lice Remover System] 1049759
    • {1 (60 ML) (benzalkonium chloride 1 MG/ML Topical Solution) / 1 (60 ML) (piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo) } Pack 1049756

Showing up to 8 concepts per family — 24 of 26 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Piperonyl butoxide 40 MG/ML SCDC · 330135
  • Pyrethrins 3.3 MG/ML SCDC · 333696
  • Piperonyl butoxide / pyrethrins Medicated Shampoo SCDF · 377511
  • Piperonyl butoxide / pyrethrins Shampoo Product SCDG · 1295306
  • {1 (60 ML) (benzalkonium chloride 1 MG/ML Topical Solution) / 1 (60 ML) (piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo) } Pack GPCK · 1049756

Brand-Name Concepts

  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [Herklin] SBD · 1988409
  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [Pronto Plus] SBD · 729773
  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML Medicated Shampoo [RID] SBD · 864131
  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [Herklin] SBDC · 1988406
  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [Pronto Plus] SBDC · 729771
  • Piperonyl butoxide 40 MG/ML / pyrethrins 3.3 MG/ML [RID] SBDC · 864130
  • Piperonyl butoxide / pyrethrins Medicated Shampoo [Herklin] SBDF · 1988407
  • Piperonyl butoxide / pyrethrins Medicated Shampoo [Pronto Plus] SBDF · 729772
  • Piperonyl butoxide / pyrethrins Medicated Shampoo [RID] SBDF · 362502
  • Herklin Shampoo Product SBDG · 1988408

📦 FDA Products & Package NDCs

38 products · 46 package NDCs
46 package NDCs map to RxCUI 283219 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-1253-02 1 BOTTLE in 1 CARTON (0363-1253-02) / 59 mL in 1 BOTTLE Walgreens Lice Killing Walgreens CO 2019-02-21
00363-1253-04 118 mL in 1 BOTTLE (0363-1253-04) Walgreens Lice Killing Walgreens CO 2019-02-21
00363-1253-08 1 BOTTLE in 1 CARTON (0363-1253-08) / 237 mL in 1 BOTTLE Walgreens Lice Killing Walgreens CO 2019-02-25
00363-3255-01 1 KIT in 1 CARTON (0363-3255-01) * 118 mL in 1 BOTTLE * 5... Walgreens Lice Elimination Walgreens 2014-01-03
00904-7349-20 1 BOTTLE in 1 CARTON (0904-7349-20) / 118 mL in 1 BOTTLE Major Lice Killing Major Pharmaceuticals 2023-11-01
11383-0001-04 1 BOTTLE in 1 CARTON (11383-001-04) / 118 mL in 1 BOTTLE Lice No More Lice Killing Weeks & Leo Co., Inc 2025-07-01
11383-0253-02 1 BOTTLE in 1 CARTON (11383-253-02) / 59 mL in 1 BOTTLE Lice Killing Weeks & Leo Co., Inc. 2012-10-11
11383-0253-04 1 BOTTLE in 1 CARTON (11383-253-04) / 118 mL in 1 BOTTLE Lice Killing Weeks & Leo Co., Inc. 2012-10-11
11383-0253-06 1 BOTTLE in 1 CARTON (11383-253-06) / 177 mL in 1 BOTTLE Lice Killing Weeks & Leo Co., Inc. 2012-10-11
11383-0253-08 1 BOTTLE in 1 CARTON (11383-253-08) / 237 mL in 1 BOTTLE Lice Killing Weeks & Leo Co., Inc. 2017-10-11
11383-0255-01 1 KIT in 1 CARTON (11383-255-01) * 118 mL in 1 BOTTLE Weeks and Leo Complete Lice Treatment Weeks & Leo Co., Inc. 2014-01-03
11383-0310-02 1 BOTTLE in 1 CARTON (11383-310-02) / 59 mL in 1 BOTTLE Lice Killing Weeks & Leo Co., Inc. 2021-05-17
11383-0312-02 1 BOTTLE in 1 CARTON (11383-312-02) / 59 mL in 1 BOTTLE ABC Lice Killing Weeks & Leo Co., Inc. 2012-06-18
11822-6611-01 1 KIT in 1 CARTON (11822-6611-1) * 118 mL in 1 BOTTLE * 5... Rite Aid Complete Lice Elimination Kit Rite Aid 2023-08-29
11822-6616-01 1 BOTTLE in 1 CARTON (11822-6616-1) / 236 mL in 1 BOTTLE Rite Aid Lice Killing Rite Aid Corp 2023-11-01
24286-0253-04 1 BOTTLE in 1 CARTON (24286-0253-4) / 118 mL in 1 BOTTLE ZAP Lice Killing DLC laboratories Inc. 2019-02-21
24286-1253-02 1 BOTTLE in 1 CARTON (24286-1253-2) / 59 mL in 1 BOTTLE Quita Piojos Lice Killing DLC Laboratories 2019-02-21
30142-0252-01 1 KIT in 1 CARTON (30142-252-01) * 118 mL in 1 BOTTLE (301... Kroger Complete Lice Treatment Kit The Kroger Co 2023-10-01
30142-0253-08 1 BOTTLE in 1 CARTON (30142-253-08) / 236 mL in 1 BOTTLE Kroger Lice Killing The Kroger Co 2023-11-01
46122-0759-29 1 BOTTLE in 1 CARTON (46122-759-29) / 118 mL in 1 BOTTLE GNP Lice Killing AmerisourceBergen Drug Corporation 2023-11-01
48201-0006-08 1 BOTTLE in 1 CARTON (48201-006-08) / 237 mL in 1 BOTTLE Mata Piojos Lice GRANDALL DISTRIBUTING, LLC 2018-06-01
48201-0006-59 1 BOTTLE in 1 CARTON (48201-006-59) / 59 mL in 1 BOTTLE Mata Piojos Lice GRANDALL DISTRIBUTING, LLC 2015-07-09
50804-0253-04 1 BOTTLE in 1 CARTON (50804-253-04) / 118 mL in 1 BOTTLE GoodSense Lice Killing Perrigo Direct, Inc. 2023-11-01
50804-0255-01 1 KIT in 1 CARTON (50804-255-01) * 118 mL in 1 BOTTLE * 5... GoodSense Complete Lice Treatment Kit Perrigo Direct, LLC 2023-10-01
53943-0253-02 1 BOTTLE in 1 CARTON (53943-253-02) / 59 mL in 1 BOTTLE Discount Drug Mart Lice Killing Discount Drug Mart 2014-01-03
53943-0253-04 1 BOTTLE, DISPENSING in 1 CARTON (53943-253-04) / 118 mL in... Discount Drug Mart Lice Killing Discount Drug Mart 2010-10-28
53943-0255-01 1 KIT in 1 CARTON (53943-255-01) * 59 mL in 1 BOTTLE, SPRA... Discount Lice Treatment Discount drug mart 2014-01-03
55319-0253-08 1 BOTTLE in 1 CARTON (55319-253-08) / 236 mL in 1 BOTTLE Family Wellness Lice Killing Family Dollar 2023-11-01
55758-0253-02 1 BOTTLE in 1 CARTON (55758-253-02) / 59 mL in 1 BOTTLE El Piojito Lice Killing Pharmadel 2014-01-03
63941-0253-04 1 BOTTLE in 1 CARTON (63941-253-04) / 118 mL in 1 BOTTLE Best Choice Lice Killing Valu Merchandisers, CO. 2014-01-03
63941-0522-01 1 KIT in 1 CARTON (63941-522-01) * 59 mL in 1 BOTTLE, SPRA... Best Choice Lice Treatment Associated Wholesale Grocers, Inc. 2014-01-03
68016-0253-04 1 BOTTLE in 1 CARTON (68016-253-04) / 118 mL in 1 BOTTLE Lice Killing PHARMACY VALUE ALLIANCE LLC 2020-10-12
68016-0552-01 1 KIT in 1 CARTON (68016-552-01) * 118 mL in 1 BOTTLE * 5... Premier Value Lice Treatment Kit PHARMACY VALUE ALLIANCE LLC 2020-12-09
69842-0250-04 1 BOTTLE in 1 CARTON (69842-250-04) / 177 mL in 1 BOTTLE CVS Health Lice Killing CVS 2014-01-03
69842-0250-08 1 BOTTLE in 1 CARTON (69842-250-08) / 236 mL in 1 BOTTLE CVS Health Lice Killing CVS 2010-10-28
69842-0255-01 1 KIT in 1 CARTON (69842-255-01) * 118 mL in 1 BOTTLE CVS 3 Step Lice Solution CVS 2014-01-03
69842-0255-02 1 KIT in 1 CARTON (69842-255-02) * 59 mL in 1 BOTTLE, SPRA... CVS 3 Step Lice Solution CVS 2014-01-03
70000-0633-01 1 BOTTLE in 1 CARTON (70000-0633-1) / 118 mL in 1 BOTTLE Leader Lice Killing LEADER/ Cardinal Health 110, Inc. 2023-06-21
70677-1184-01 1 BOTTLE in 1 CARTON (70677-1184-1) / 118 mL in 1 BOTTLE Foster and Thrive Lice Killing Strategic Sourcing Services, LLC 2023-11-01
75940-0192-09 59 mL in 1 BOTTLE (75940-192-09) Herklin Lice Treatment MarcasUSA LLC 2018-07-16
76162-0253-08 1 BOTTLE in 1 CARTON (76162-253-08) / 236 mL in 1 BOTTLE Topcare Lice Killing Topco Associates, LLC 2023-11-01
76162-0255-01 1 KIT in 1 CARTON (76162-255-01) * 118 mL in 1 BOTTLE (761... Topcare Complete Lice Treatment Kit Topco Associates, LLC 2023-10-01
79481-2530-08 1 BOTTLE in 1 CARTON (79481-2530-8) / 236 mL in 1 BOTTLE Meijer Lice Killing Meijer, Inc. 2023-09-01
79481-2550-01 1 KIT in 1 CARTON (79481-2550-1) * 118 mL in 1 BOTTLE * 5... Meijer Complete Lice Treatment Kit Meijer, Inc. 2020-12-09
83324-0268-01 1 KIT in 1 CARTON (83324-268-01) * 118 mL in 1 BOTTLE Quality Choice Lice Treatment Chain Drug Marketing Association 2024-09-09
83324-0269-04 1 BOTTLE in 1 CARTON (83324-269-04) / 118 mL in 1 BOTTLE Quality Choice Lice Killing Quality Choice 2014-01-03
Observed labelers: Weeks & Leo Co., Inc. (7) · CVS (4) · Discount Drug Mart (3) · Walgreens CO (3) · GRANDALL DISTRIBUTING, LLC (2) · Meijer, Inc. (2) · +22 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.