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Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet — RxCUI 308297

RxNorm drug concept · Semantic clinical drug
RxCUI 308297 Semantic clinical drug · SCD ● Current RxNorm concept 168 FDA products 334 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI308297
Official nameAcetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet
FDA products mapped168
Package NDCs mapped334
Reported Medicaid activity (SDUD)11,352 prescriptions · 22 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Acetaminophen Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Great question. The IV form is used when you can't take medication by mouth — for example, after surgery, if you're nauseated, or if you need faster, more reliable absorption. It d...
  • Why am I getting acetaminophen through an IV instead of just taking a pill?
  • Yes, Acetaminophen Injection is approved for children — for pain relief in kids 2 years and older, and for fever reduction in patients of all ages, including premature newborns bor...
  • The most important things to watch for are signs of a serious allergic reaction — swelling of your face, mouth, or throat, trouble breathing, or hives — and any new skin rash. Eith...
📖 Read our full Acetaminophen Injection guide →

🕸️ Concept Web — How Acetaminophen 250 MG / aspirin 250 MG / caffeine... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet RxCUI 308297

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Aspirin 1191
    • Caffeine 1886
    • Acetaminophen / aspirin / caffeine 466584
  2. Brand names 6

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Anacin Advanced Headache Formula 721973
    • Arthriten Inflammatory Pain 1303154
    • Backaid IPF 1361397
    • Exaprin Plus 2723563
    • Excedrin 217020
    • Pamprin Max Formula 1052413
  3. Dose forms 24

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / aspirin / caffeine Oral Tablet 238142
    • Acetaminophen / aspirin / caffeine Oral Product 1154257
    • Acetaminophen / aspirin / caffeine Pill 1154258
    • Acetaminophen / aspirin / caffeine Oral Tablet [Anacin Advanced Headache Formula] 723532
    • Acetaminophen / aspirin / caffeine Oral Tablet [Arthriten Inflammatory Pain] 1303156
    • Acetaminophen / aspirin / caffeine Oral Tablet [Backaid IPF] 1361399
    • Acetaminophen / aspirin / caffeine Oral Tablet [Exaprin Plus] 2723567
    • Acetaminophen / aspirin / caffeine Oral Tablet [Excedrin] 369063
    • +16 more in this family
  4. Clinical & branded drugs 15

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

  5. Packs 2

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 28 of 51 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

📦 FDA Products & Package NDCs

168 products · 334 package NDCs
334 package NDCs map to RxCUI 308297 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
79903-0044-20 200 TABLET, COATED in 1 BOTTLE (79903-044-20) EXTRA STRENGTH HEADACHE RELIEF WAL-MART STORES INC 2022-03-09
79903-0044-42 1 BOTTLE in 1 CARTON (79903-044-42) / 24 TABLET, COATED in... EXTRA STRENGTH HEADACHE RELIEF WAL-MART STORES INC 2022-03-09
79903-0216-10 1 BOTTLE in 1 CARTON (79903-216-10) / 100 TABLET, FILM COAT... ACETAMINOPHEN ASPIRIN AND CAFFEINE WALMART INC. 2024-02-28
79903-0370-20 200 TABLET in 1 BOTTLE (79903-370-20) Headache Relief Walmart Inc. 2024-07-30
79903-0370-21 2 BOTTLE in 1 CARTON (79903-370-21) / 100 TABLET in 1 BOTTL... Headache Relief Walmart Inc. 2024-07-30
80513-0362-15 150 TABLET in 1 BOTTLE (80513-362-15) Extra Strength Headache Relief Advanced Rx LLC 2025-07-01
81522-0205-03 1 BOTTLE, PLASTIC in 1 CARTON (81522-205-03) / 100 TABLET i... Migraine Relief FSA STORE INC. 2023-01-11
82725-1023-01 300 TABLET in 1 BOTTLE (82725-1023-1) ValuMeds Extra Strength Headache Relief Cabinet Health P.B.C. 2025-01-25
82804-0002-30 30 TABLET, FILM COATED in 1 BOTTLE (82804-002-30) good sense migraine formula Proficient Rx LP 2023-08-24
82804-0002-60 60 TABLET, FILM COATED in 1 BOTTLE (82804-002-60) good sense migraine formula Proficient Rx LP 2023-08-24
82804-0002-90 90 TABLET, FILM COATED in 1 BOTTLE (82804-002-90) good sense migraine formula Proficient Rx LP 2023-08-24
82804-0008-30 30 TABLET, FILM COATED in 1 BOTTLE (82804-008-30) Acetaminophen, Aspirin, Caffeine Proficient Rx LP 2023-10-05
82804-0008-60 60 TABLET, FILM COATED in 1 BOTTLE (82804-008-60) Acetaminophen, Aspirin, Caffeine Proficient Rx LP 2023-10-05
82804-0008-90 90 TABLET, FILM COATED in 1 BOTTLE (82804-008-90) Acetaminophen, Aspirin, Caffeine Proficient Rx LP 2023-10-05
82804-0163-60 60 TABLET, FILM COATED in 1 BOTTLE (82804-163-60) EXTRA STRENGTH PAIN RELIEVER Proficient Rx LP 2024-10-31
83324-0099-24 1 BOTTLE, PLASTIC in 1 CARTON (83324-099-24) / 24 TABLET in... Migraine Relief CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-05-01
83324-0331-01 1 BOTTLE, PLASTIC in 1 CARTON (83324-331-01) / 100 TABLET,... Headache Relief Chain Drug Marketing Association, Inc. 2025-09-02
83324-0331-24 1 BOTTLE, PLASTIC in 1 CARTON (83324-331-24) / 24 TABLET, F... Headache Relief Chain Drug Marketing Association, Inc. 2025-09-02
84324-0007-01 100 TABLET in 1 BOTTLE (84324-007-01) Nuvicare Headache Relief NUVICARE LLC 2024-07-17
85237-1868-01 1 POUCH in 1 BLISTER PACK (85237-1868-1) / 2 TABLET, FILM C... Excedrin Extra Strength Headache Select Consumer Group 2024-01-01
85237-1868-02 2 POUCH in 1 BLISTER PACK (85237-1868-2) / 2 TABLET, FILM C... Excedrin Extra Strength Headache Select Consumer Group 2024-01-01
85237-1868-03 25 POUCH in 1 BOX, UNIT-DOSE (85237-1868-3) / 2 TABLET, FIL... Excedrin Extra Strength Headache Select Consumer Group 2025-12-24
85237-1868-06 50 POUCH in 1 BOX, UNIT-DOSE (85237-1868-6) / 2 TABLET, FIL... Excedrin Extra Strength Headache Select Consumer Group 2025-12-24
85237-1871-01 1 POUCH in 1 BLISTER PACK (85237-1871-1) / 2 TABLET, FILM C... Excedrin Migraine Select Consumer Group 2025-12-24
85237-1871-02 2 POUCH in 1 BLISTER PACK (85237-1871-2) / 2 TABLET, FILM C... Excedrin Migraine Select Consumer Group 2025-12-24
85237-1871-03 25 POUCH in 1 BOX, UNIT-DOSE (85237-1871-3) / 2 TABLET, FIL... Excedrin Migraine Select Consumer Group 2025-12-24
85237-1871-04 50 POUCH in 1 BOX, UNIT-DOSE (85237-1871-4) / 2 TABLET, FIL... Excedrin Migraine Select Consumer Group 2025-12-24
85237-1871-07 3 POUCH in 1 BLISTER PACK (85237-1871-7) / 2 TABLET, FILM C... Excedrin Migraine Select Consumer Group 2025-12-24
85766-0173-01 50 PACKET in 1 BOX (85766-173-01) / 2 TABLET, FILM COATED i... Medique Pain Off Sportpharm LLC 2026-02-27
85766-0173-02 100 PACKET in 1 BOX (85766-173-02) / 2 TABLET, FILM COATED... Medique Pain Off Sportpharm LLC 2026-02-27
85766-0173-05 250 PACKET in 1 BOX (85766-173-05) / 2 TABLET, FILM COATED... Medique Pain Off Sportpharm LLC 2026-02-27
85766-0180-01 1 BOTTLE in 1 CARTON (85766-180-01) / 100 TABLET, FILM COAT... good sense migraine formula Sportpharm LLC 2026-03-07
85786-0105-90 100 TABLET, COATED in 1 BOTTLE, PLASTIC (85786-105-90) Dr Simi Extra Strength Acetaminophen 250 mg, Aspirin 250 mg, and Caffeine 65 mg Farmacias De Similares TX LLC 2026-01-01
85828-0285-93 1 BOTTLE in 1 CARTON (85828-285-93) / 24 TABLET, FILM COATE... Headache Relief Extra Strength Grocery Outlet 2026-03-17
Observed labelers: Haleon US Holdings LLC (69) · Lil' Drug Store Products, Inc. (13) · WALGREENS (13) · Aurohealth LLC (12) · CVS Pharmacy (12) · Select Consumer Group (9) · +83 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.