Epinephrine Injection shortage
Epinephrine Injection is currently listed in shortage by the FDA. The FDA lists 2 affected products. This page was last refreshed from FDA data on Sep 25, 2026.
Pfizer (Hospira) is permanently stopping its epinephrine injection 0.1 mg/mL. The same strength is still listed as available from other manufacturers.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Epinephrine Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Nov 7, 2025Currently in shortage2 of 2 products affected.
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Nov 7, 2025First reported to the FDA2 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Hospira, Inc., a Pfizer Company 📞 844-646-4398 2 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Epinephrine, Injection, .1 mg/1 mL (NDC 0409-4933-10) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Epinephrine, Injection, .1 mg/1 mL (NDC 0409-4933-01) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Epinephrine Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Epinephrine Injection? options further down this page.
Why is Epinephrine Injection in shortage?
Hospira, Inc. (a Pfizer company) has reported to the FDA that it is permanently stopping the manufacture of its epinephrine injection in the 0.1 mg/1 mL strength and package size. This affects two specific package configurations of that product (NDC 0409-4933-01 and NDC 0409-4933-10). Hospira did not share a specific public reason for why they made this decision — only that manufacturing of this particular product is being discontinued.
It's worth knowing that this report reflects only what Hospira submitted to the FDA about their own product. It does not mean epinephrine injection as a whole is going away — only this specific strength and packaging from this one manufacturer.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Epinephrine Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Epinephrine Injection?
Epinephrine Injection is currently on the FDA shortage list, and I want to walk you through what that means for you.
The strength involved is the 0.1 mg/1 mL injection. According to the report, this strength has no available source right now from the manufacturer who filed it, Hospira (a Pfizer company). The reason listed is that this manufacturer is discontinuing production of the drug. Because this is a discontinuation rather than a temporary delay, this particular supply problem may be permanent for that company's product.
It's important to know this report reflects only one manufacturer. Other companies still list the same medicine — the same 0.1 mg/mL epinephrine injection — including A-S Medication Solutions, HealthFirst, and International Medication Systems. Your pharmacy may be able to source one of these, though it may not be in local stock.
Here is what I'd suggest:
- Do not stop, skip, or change your dose on your own.
- Ask your pharmacy to check wholesalers and other manufacturers for the same medicine from another maker.
- Because this product is being discontinued, talk with your prescriber or pharmacist about a suitable option going forward.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. Local stock can differ from this national data.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Where else can I get Epinephrine Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Epinephrine Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Epinephrine | EPINEPHRINE .1 mg/mL | Injection · Intravenous | A-S Medication Solutions | 50090-7037-00 |
| Epinephrine | EPINEPHRINE .1 mg/mL | Injection · Intravenous | HF Acquisition Co LLC, DBA HealthFirst | 51662-1629-01 |
| Epinephrine | EPINEPHRINE .1 mg/mL | Injection · Intravenous | International Medication Systems, Limited | 76329-3318-01 |
Alternative dosage forms of Epinephrine
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 9 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Epinephrine 0.1 mg/mL | Hospira, | 1 syringe | $1.194 | — | Discontinued |
| Epinephrine .1 mg/mL | International | 1 syringe | $1.238 | — | Availability likely |
| Epinephrine .1 mg/mL | Henry | 1 syringe | — | — | FDA listed |
| Epinephrine .1 mg/mL | A-S | 1 ml | — | — | FDA listed |
| Epinephrine .1 mg/mL | HF | 1 syringe | — | — | FDA listed |
| Epinephrine .1 mg/mL | HF | 1 syringe | — | — | FDA listed |
| Epinephrine .1 mg/mL | REMEDYREPACK | 1 syringe | — | — | FDA listed |
| Epinephrine .1 mg/mL | Medical | 1 syringe | — | — | FDA listed |
| Epinephrine .1 mg/mL | Medical | 1 syringe | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Epinephrine Injection — that fall in the same broad treatment class (adrenergic agents,catecholamines) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other cardiovascular, endocrinology/metabolism shortages
Epinephrine Injection shortage FAQs
Is Epinephrine Injection in shortage?
Which products are affected?
When will Epinephrine Injection be available again?
Can I still get Epinephrine somewhere?
What should I do if I take Epinephrine Injection?
Still have a question about the Epinephrine Injection shortage?
Ask a pharmacist about this shortage →View Epinephrine Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.