Palonosetron Hydrochloride Injection shortage
Palonosetron Hydrochloride Injection is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Oct 2, 2026.
Teva is permanently stopping production of palonosetron hydrochloride injection 0.25 mg/5 mL. Other makers — including Sandoz, NorthStar Rx, Sagent, and Baxter — still list this medicine as available.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Palonosetron Hydrochloride Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Nov 14, 2025Currently in shortage1 of 1 product affected.
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Nov 14, 2025First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Teva Pharmaceuticals USA, Inc. 📞 800-545-8800 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Palonosetron Hydrochloride, Injection, .25 mg/5 mL (NDC 0703-4094-01) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Palonosetron Hydrochloride Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Palonosetron Hydrochloride Injection? options further down this page.
Why is Palonosetron Hydrochloride Injection in shortage?
Teva Pharmaceuticals has reported to the FDA that they are permanently stopping the manufacturing of their version of palonosetron hydrochloride injection 0.25 mg/5 mL (the vial size). This means that particular product from Teva will no longer be produced going forward.
No specific reason was shared publicly by Teva for why they are making this decision — they simply reported the discontinuation to the FDA. It's also worth knowing that this report only reflects Teva's product. Other manufacturers of palonosetron injection are listed separately and are not part of this specific report.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Palonosetron Hydrochloride Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Palonosetron Hydrochloride Injection?
Palonosetron hydrochloride injection, a medicine used to help prevent nausea and vomiting, is currently on the FDA shortage list. I want to walk you through what this means so you can plan calmly.
The strength affected is the 0.25 mg/5 mL injection. Teva Pharmaceuticals has reported this product as to be discontinued — the reason given is that they are stopping its manufacture. Because this reflects Teva's decision, it means their supply may not return, though this record covers only that one maker. The good part to keep in mind: several other companies still list the same medicine, so it is not gone from the market as a whole.
Here is what I suggest:
- Do not stop or change how you receive this medicine on your own. Since it is given by injection, your care team manages the dosing.
- Ask your pharmacy or clinic to check whether the same medicine is available from another maker. From our records, Sandoz, Baxter, Eugia, Apotex, Fresenius Kabi, Mylan, Cipla, and Meitheal list the 0.25 mg/5 mL form. It may not be in local stock, but your pharmacy can check wholesalers.
- Because Teva's version is being discontinued, ask your prescriber or pharmacist about the best next step, such as a clinician-chosen equivalent.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. This is general national information and may not match your local stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Palonosetron Hydrochloride Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Palonosetron Hydrochloride Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection, Solution · Intravenous | Sandoz Inc | 00781-3312-75 |
| Palonosetron | PALONOSETRON HYDROCHLORIDE .05 mg/mL | Injection, Solution · Intravenous | NorthStar Rx LLC | 16714-0834-01 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .05 mg/mL | Injection, Solution · Intravenous | Sagent Pharmaceuticals | 25021-0783-05 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection · Intravenous | Baxter Healthcare Corporation | 36000-0326-02 |
| Palonosetron | PALONOSETRON HYDROCHLORIDE .05 mg/mL | Injection, Solution · Intravenous | Dr.Reddy's Laboratories Limited | 55111-0694-07 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection, Solution · Intravenous | Eugia US LLC | 55150-0186-05 |
| Palonosetron | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection · Intravenous | Apotex Corp. | 60505-6193-01 |
| Palonosetron | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection, Solution · Intravenous | Fresenius Kabi USA, LLC | 63323-0673-05 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection, Solution · Intravenous | Mylan Institutional LLC | 67457-0317-25 |
| Palonosetron | PALONOSETRON HYDROCHLORIDE .05 mg/mL | Injection, Solution · Intravenous | BluePoint Laboratories | 68001-0355-25 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection · Intravenous | Cipla USA Inc. | 69097-0927-35 |
| Palonosetron Hydrochloride | PALONOSETRON HYDROCHLORIDE .25 mg/5mL | Injection, Solution · Intravenous | Meitheal Pharmaceuticals Inc. | 71288-0409-05 |
Therapeutic equivalents & pricing 19 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Palonosetron Hydrochloride .25 mg/5mL | Teva | 1 vial | — | — | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Sandoz | 1 vial | — | AP | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Sandoz | 1 vial | — | AP | Discontinued |
| Palonosetron .05 mg/mL | NorthStar | 1 vial | — | AP | FDA listed |
| palonosetron hydrochloride .05 mg/mL | Sagent | 1 vial | — | AP | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Baxter | 1 vial | — | — | FDA listed |
| Palonosetron .05 mg/mL | Dr.Reddy's | 1 vial | — | AP | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Eugia | 1 vial | — | AP | FDA listed |
| Palonosetron .25 mg/5mL | Apotex | 1 vial | — | — | FDA listed |
| Palonosetron .25 mg/5mL | Apotex | 1 vial | — | — | FDA listed |
| Palonosetron .25 mg/5mL | Fresenius | 1 vial | — | AP | FDA listed |
| Palonosetron .25 mg/5mL | Qilu | 1 vial | — | — | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Mylan | 1 vial | — | AP | FDA listed |
| Palonosetron .05 mg/mL | BluePoint | 1 vial | — | AP | FDA listed |
| palonosetron hydrochloride .25 mg/5mL | Cipla | 1 vial | — | — | FDA listed |
| Palonosetron Hydrochloride .25 mg/5mL | Meitheal | 1 vial | — | AP | FDA listed |
| Palonosetron Hydrochloride .05 mg/mL | Avenacy, | 1 vial | — | — | Discontinued |
| posfrea .25 mg/5mL | Avyxa | 1 vial | — | — | FDA listed |
| Palonosetron .25 mg/5mL | BLuePoint | 1 vial | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Palonosetron Hydrochloride Injection — that fall in the same broad treatment class (antiemetic/antivertigo agents) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other gastroenterology shortages
Palonosetron Hydrochloride Injection shortage FAQs
Is Palonosetron Hydrochloride Injection in shortage?
Which products are affected?
When will Palonosetron Hydrochloride Injection be available again?
Can I still get Palonosetron Hydrochloride somewhere?
What should I do if I take Palonosetron Hydrochloride Injection?
Still have a question about the Palonosetron Hydrochloride Injection shortage?
Ask a pharmacist about this shortage →View Palonosetron Hydrochloride Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.