Acetaminophen, Butalbital, Codeine Phosphate & Nutrient Depletion
Also searched as Phrenilin #3. What the clinical evidence reports, what it may mean, and what to discuss with your pharmacist.
Acetaminophen, Butalbital, Codeine Phosphate has been associated with depletion of GLUTATHIONE. This does not mean a deficiency will occur — it means these are worth knowing about and, if you take Acetaminophen, Butalbital, Codeine Phosphate long-term, worth raising with your pharmacist or healthcare provider.
Take more than one medication? Open the checker with Acetaminophen, Butalbital, Codeine Phosphate pre-loaded and add the rest to see overlapping nutrient signals.
Reported nutrient depletions with Acetaminophen, Butalbital, Codeine Phosphate
Each record below is shown as published in our licensed clinical database, with its evidence rating and citations. Expand a section for food sources and talking points.
GLUTATHIONE
Insufficient EvidenceACETAMINOPHEN
Chronic or excessive acetaminophen has been associated with low levels of glutathione. Usually a cysteine containing supplement is used to replenish glutathione. Cysteine is converted to glutathione in the body.
Glutathione is a natural antioxidant your body makes to protect cells from damage and help clear out harmful byproducts. The acetaminophen in this combination product is processed in the liver, and that process can use up glutathione, especially when acetaminophen is taken in large amounts or over a long period of time. That said, the evidence here is rated as insufficient, meaning researchers have not yet confirmed how much this matters at normal doses. If you take this medication regularly, it is worth mentioning to your pharmacist or doctor at your next visit.
Learn more about this nutrient: Glutathione — uses, safety & interactions
References (1)
- Herzenberg LA, De Rosa SC, Dubs JG, et al. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci USA 1997;94:1967-72. PubMed
This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.
Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
More about Acetaminophen, Butalbital, Codeine Phosphate
What drug-induced nutrient depletion means
Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.
Association is not deficiency
An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.
Evidence varies by pair
Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.
When to ask about labs
If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.
Don't self-supplement blindly
Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.
Never stop a medication over this
These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.
Food first, usually
For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.
Acetaminophen, Butalbital, Codeine Phosphate & nutrients: FAQs
Does Acetaminophen, Butalbital, Codeine Phosphate deplete GLUTATHIONE?
Should I take a supplement because I take Acetaminophen, Butalbital, Codeine Phosphate?
Should I stop taking Acetaminophen, Butalbital, Codeine Phosphate?
Where does this information come from?
Questions about Acetaminophen, Butalbital, Codeine Phosphate and your nutrition?
Ask a licensed pharmacist — free, no appointment needed.
Sources & How We Checked
Nutrient depletion records for Acetaminophen, Butalbital, Codeine Phosphate are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for drug-induced nutrient depletions, supplements, and interactions — the basis for this page.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for medication overviews across the site.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.