Can You Crush Hydrochlorothiazide?

In our latest question and answer, the pharmacist discusses whether or not hydrochlorothiazide tablets can be crushed.

Question

I know hydrochlorothiazide tablets are small but for some reason, I'm still having issues swallowing them. Are they okay and safe to crush up?

Asked by Sallean On Jun 11, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jun 11, 2022
Last updated Jun 11, 2022

Key points

  • Hydrochlorothiazide tablets can be safely crushed and mixed with food or a liquid.
  • Hydrochlorothiazide capsules should not be crushed.
  • Hydrochlorothiazide is not available commercially in a liquid form but some pharmacies can compound it.

Thanks for reaching out!

Yes, hydrochlorothiazide tablets can be crushed and mixed with a liquid or food before taking.

I emphasize tablets because hydrochlorothiazide also is available in capsule form. The capsule form of hydrochlorothiazide should not be crushed, but, if you need to, the capsules can be opened and the contents mixed with liquid or food before taking.

After crushing a hydrochlorothiazide tablet, it is important to take your dose right away. You should not store the crushed powder for future use.

Is There A Liquid Version?

There is no commercially available liquid version of hydrochlorothiazide on the market currently.

There used to be a 50mg/5mL solution, manufactured by Hikma Pharmaceuticals, but that was discontinued, unfortunately.

If you are finding that you need to crush your hydrochlorothiazide tablets for every single dose you take, and you find that cumbersome, you may be able to find a pharmacy that can compound a liquid version for you.

Several studies have found that a liquid version, made at a concentration of either 2mg/mL or 5mg/mL, can be safely compounded and stored at room temperature for up to 10 weeks.

You likely would have to find a pharmacy specializing in compounding though to have this as an option. It may be much more expensive than just continuing to use tablets as well.

Final Words

Thanks again for your question and please don't hesitate to reach back out!

References

  • Neonates need tailored drug formulations, PubMed
  • Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids, PubMed
  • Luukkonen P, Totterman AM, Rasilainen M, et al: Formulation of enteral hydrochlorothiazide suspension intended for premature infants.

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at Hello@HelloPharmacist.com! You can also connect with Dr. Brian Staiger on LinkedIn.

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