Can You Take Buspar And Effexor Together?

Answer

While Buspar and Effexor are sometimes prescribed together, they do have an interaction that is important to be aware of.

In fact, there are essentially two different types of interactions between these drugs. They can:

• Increase the risk of a rare, but serious condition known as serotonin syndrome
• Increase the risk of bleeding as both have mild antiplatelet effects

Like all prescription drugs, it is important to weigh the risks and benefits of therapy.

Interaction Details

There are a number of drugs that affect the neurotransmitter serotonin, and both of these drugs do just that.

Effexor (venlafaxine) is classified as an SNRI (serotonin-norepinephrine reuptake inhibitor) and increases serotonin concentration in the brain. Buspar (buspirone) has activity at several different serotonin receptors, and is thought to affect some dopamine and GABA receptors as well.

Serotonin has wide-ranging effects on the body, and side effects with drugs that affect serotonin are well-documented. These risks increase if you take more than one drug that affects serotonin. These side effects include the rare but serious 'serotonin syndrome', and an increased bleeding risk.

How To Manage The Interaction

Even though there is an interaction between Effexor and Buspar, they are oftentimes prescribed together for those suffering from several mental health conditions, such as depression and anxiety.

The risk of side effects is important to be aware of so you can take appropriate action if they occur.

In regard to serotonin syndrome, it is important to look for the following symptoms:

• Muscle rigidity
• Increased body temperature
• Sweating
• Mental status changes
• Confusion
• Flu-like symptoms

It is important to be aware of these symptoms and seek medical attention should they occur.

I also mentioned there is an increased bleeding risk. Serotonin has complex effects on blood coagulation, and taking multiple serotonergic drugs can have an antiplatelet effect.

You want to be on the lookout for any unusual bruising or bleeding while taking Effexor and Buspar together. Generally, the increased risk of bleeding is predominately stomach bleeds, so look for black or tarry-looking stools.

These side effects (serotonin syndrome and bleeding risk) are relatively uncommon, but again, good to know about. Ideally, you should start at the lowest dose of each drug and increase slowly until you reach the desired clinical effects.

Final Words

I hope you found this answer helpful.

I want to emphasize that these drugs are sometimes used together. Even though the side effects I discussed sound serious (and they certainly can be), they are relatively uncommon.

It is always good to know what could happen, and what to look out for, so you and your doctor can make an informed decision about your therapy.