Can You Take Claritin With Vistaril (Hydroxyzine)?

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between Claritin (loratadine) and Vistaril (hydroxyzine).

2 min read Updated Jun 2026 Read by 10,422 people
Can You Take Claritin With Vistaril (Hydroxyzine)?
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Jess asked

Can I take Vistaril 25mg with Claritin?

Sep 13, 2022
The quick answer
  • Claritin and Vistaril can be taken together, but both medications may increase drowsiness, fatigue, and dry mouth since they have overlapping side effects.
  • You should not exceed the recommended daily doses of either medication and should watch for excessive sleepiness or slow breathing while taking them together.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

Claritin and Vistaril can be taken together, but the side effects may be enhanced due to them both causing similar side effects. It is important to note no more than the recommended doses per day should be taken.

Side effects that may be enhanced by taking both would be:

  • Drowsiness
  • Fatigue
  • Dry mouth

First-generation antihistamines typically cause more side effects than second-generation antihistamines. Vistaril is classified as first-generation and Claritin is second-generation. They work somewhat differently, and therefore do not have the same incidence of causing side effects. Although Claritin has a smaller chance of causing side effects and sedation, it is still important to monitor for excessive sleepiness or slow breathing.

Per the prescribing information, Vistaril can be used for multiple reasons, one being for itching due to allergic conditions. Unless experiencing other allergic symptoms or the Vistaril is ineffective, Claritin may be useful.

Vistaril Information

Uses

  • Anxiety
  • Sedation
  • Nausea
  • Itching due to allergies

Cautions

  • Drowsiness and sedation may be increased with other CNS depressants, such as narcotics, barbiturates, non-narcotic analgesics, first-generation antihistamines, and alcohol
  • Risk of prolonged QT interval in combination with other medications that can prolong QT interval (antiarrhythmics, ziprasidone, iloperidone, clozapine, quetiapine, chlorpromazine, citalopram, azithromycin, erythromycin, clarithromycin, levofloxacin, moxifloxacin, methadone, ondansetron)
  • Risk of confusion and sedation in the elderly

Contraindications

  • Early pregnancy
  • Prolonged QT interval
  • Hypersensitivity to the medication or cetirizine or levocetirizine

Side effects

  • Dry mouth
  • Drowsiness
  • QT prolongation
  • Headache

Claritin Information

Uses

  • Relief of allergic symptoms (sneezing, itching, runny nose)

Cautions

  • Generally considered one of the preferred antihistamines in pregnancy, though use during pregnancy or breastfeeding should still be discussed with your doctor or pharmacist
  • Initial dose of 5 mg daily should be used in those with severe liver impairment

Contraindication

  • Hypersensitivity to the medication

Side effects (typically mild)

  • Nausea
  • Dry mouth
  • Headache
  • Fatigue
  • Drowsiness

Final Words

Thanks for your question! Reach back out anytime.

References & sources
  1. Hydroxyzine Prescribing Information — Pfizer
  2. Safe Use of Antihistamines — Poison Control
Glossary — Terms in This Answer
Antihistamines
Medications that block the effects of histamine, a natural chemical in the body that causes allergy symptoms.
First-generation antihistamines
Older antihistamines that cross into the brain more easily and tend to cause more side effects like drowsiness.
Second-generation antihistamines
Newer antihistamines designed to cause fewer side effects and less drowsiness than first-generation versions.
CNS depressants
Substances that slow down activity in the central nervous system and can increase drowsiness or sedation.
QT interval
A measurement on an electrocardiogram that shows the heart's electrical activity; prolongation can be dangerous.
Contraindications
Specific conditions or circumstances where a medication should not be used because it could be harmful.
Hypersensitivity
An abnormal reaction or allergy to a medication or substance.
Sedation
A state of reduced alertness or drowsiness caused by medication or other factors.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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