Can You Take Claritin With Vistaril (Hyrdoxyzine)?

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between Claritin (loratadine) and Vistaril (hydroxyzine).


Can I take Vistatil 25mg with Claritin?

Asked by Jess On Sep 13, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 13, 2022
Last updated Sep 13, 2022

Key points

  • Claritin and Vistaril can be taken together, but you may experience additive side effects, such as drowsiness and fatigue.


Claritin and Vistaril can be taken together, but the side effects may be enhanced due to them both causing similar side effects. It is important to note no more than the recommended doses per day should be taken.

Side effects that may be enhanced by taking both would be:

  • Drowsiness
  • Fatigue
  • Dry mouth

First-generation antihistamines typically cause more side effects than second-generation antihistamines. Vistaril is classified as first-generation and Claritin is second-generation. They work somewhat differently, and therefore do not have the same incidence of causing side effects. Although Claritin has a smaller chance of causing side effects and sedation, it is still important to monitor for excessive sleepiness or slow breathing.

Per the prescribing information, Vistaril can be used for multiple reasons, one being for itching due to allergic conditions. Unless experiencing other allergic symptoms or the Vistaril is ineffective, Claritin may be useful.

Vistaril Information


  • Anxiety
  • Sedation
  • Nausea
  • Itching due to allergies


  • Drowsiness and sedation may be increased with other CNS depressants, such as narcotics, barbiturates, non-narcotic analgesics, first-generation antihistamines, and alcohol
  • Risk of prolonged QT interval in combination with other medications that can prolong QT interval (antiarrhythmics, ziprasidone, iloperidone, clozapine, quetiapine, chlorpromazine, citalopram, azithromycin, erythromycin, clarithromycin, levofloxacin, moxifloxacin, methadone, ondansetron)
  • Risk of confusion and sedation in the elderly


  • Early pregnancy
  • Prolonged QT interval
  • Hypersensitivity to the medication or cetirizine or levocetirizine

Side effects

  • Dry mouth
  • Drowsiness
  • QT prolongation
  • Headache

Claritin Information


  • Relief of allergic symptoms (sneezing, itching, runny nose)


  • Not recommended in pregnancy or breastfeeding women
  • Initial dose of 5 mg daily should be used in those with severe liver impairment


  • Hypersensitivity to the medication

Side effects (typically mild)

  • Nausea
  • Dry mouth
  • Headache
  • Fatigue
  • Drowsiness

Final Words

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Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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