Can You Take Collagen Supplements With Eliquis?

In our latest question and answer, the pharmacist discusses whether or not collagen peptides can be safely taken with the anticoagulant Eliquis.


Can I take Collagen or other arthritis supplements (creams or pills) with Eliquis?

Asked by Sara On Apr 08, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 09, 2022
Last updated May 09, 2022

Key points

  • There is no known interaction between Eliquis and collagen peptides. They are considered safe to take together.

Hello and thanks for reaching out!

I'm more than happy to answer this for you, but I do want you to know it will only be a partial answer.

I can go over collagen and its safety with the anticoagulant Eliquis (apixaban), but in your question, you also mention 'other arthritis supplements'.

Without knowing the specific supplements you are referring to, it's impossible to go over whether or not they have any potential interactions with Eliquis.

In fact, you have to take special care when combining arthritis pain medications with anticoagulants as many of them do have drug interactions.

For example, NSAIDs, like ibuprofen, and naproxen, generally shouldn't be used with anticoagulant drugs since they have anticoagulant effects on their own, and can increase the risk of bleeding.

Let's get back to collagen though.

What Are Collagen Peptides?

Collagen Peptides Container

Collagen peptides, which can go by several names (e.g. hydrolyzed collagen and collagen hydrolysate) have become an increasingly popular dietary supplement promoted for a variety of health benefits.

Collagen is a structural protein found in ligaments, tendons, skin, and bones, and collagen peptide supplements, are produced by hydrolyzing collagen into small peptides, which makes them more easily absorbable.

Since collagen is a protein, collagen peptides contain a range of amino acids, although the exact amino acid profile will vary by product and collagen source (e.g. marine collagen and bovine collagen have slightly different amino acid profiles).

Nevertheless, most collagen peptide supplements are high in the amino acids hydroxyproline, glycine, and proline.

Is Collagen Safe With Eliquis?

Tablets falling out of bottle

There are no known drug interactions between collagen peptide supplements and Eliquis. They are considered safe together.

Overall, it is highly unlikely that collagen peptide supplements have interactions with the vast majority of drugs on the market as collagen is essentially just a protein source.

Unless you are taking a specific drug, or have a specific condition, where you need to watch your intake of protein or specific amino acids, you can feel safe taking collagen peptides.

One example I have of where there is the potential for an issue in this regard is between the amino acid glycine and an antipsychotic drug called clozapine.

Studies have shown that glycine could theoretically decrease the effectiveness of clozapine.

However, this would generally only be relevant if you were taking very high doses of glycine.

As it concerns Eliquis, again, there have been no reported drug interactions with collagen peptides and there isn't any reason to think they would cause problems together.

Final Words

Thanks again for contacting us!

As mentioned at the beginning of this answer, it's tough to comment on other arthritis drugs you may have in mind without knowing what they are.

Feel free to send them our way and we'll get back to you!


  • Eliquis Prescribing Information, BMS
  • 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain, PubMed
  • Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia, PubMed
  • [An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing], PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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