Can You Take DayQuil And Ibuprofen Together?

In our latest question and answer, the pharmacist discusses whether or not DayQuil and ibuprofen can safely be taken together.


I'm getting over a cold and taking DayQuil. I usually take ibuprofen when my arthritis flares up. Is it safe to combine both?

Asked by Luna On Nov 04, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 04, 2022
Last updated Jul 18, 2024

Key points

  • There is no known interaction between ibuprofen and any of the drugs contained in DayQuil.


It is safe to combine DayQuil and ibuprofen. There is no known drug interaction between them.

It is important to note that there are several 'DayQuil' products available on the market, including:

  • DayQuil Cold & Flu
  • DayQuil Cold & Flu Severe
  • DayQuil Cough DM+ Congestion
  • DayQuil High Blood Pressure

While all these products contain slightly different ingredients, they are all safe to take with ibuprofen.

Use Caution With 'DayQuil High Blood Pressure'

I do want to call out 'DayQuil High Blood Pressure' though. I'd assume if you are taking this DayQuil product, you are doing so because you have high blood pressure and want to make sure you aren't taking anything to raise it further.

NSAIDs, like ibuprofen, can raise blood pressure and increase the risk of cardiovascular events in certain individuals.

In general, NSAIDs like ibuprofen should be used cautiously if you have high blood pressure or if you have a heart condition.

So, while there is not a specific interaction between 'DayQuil High Blood Pressure' and ibuprofen, you should talk to your doctor first regarding whether or not ibuprofen is safe for you.

What Is In DayQuil?

Since you didn't mention a specific DayQuil product in your question, I'll assume for are referring to the original DayQuil. It contains:

  • Acetaminophen
  • Dextromethorphan
  • Phenylephrine

The 'severe' version of DayQuil also includes guaifenesin, an expectorant.

As mentioned, ibuprofen does not interact with any of the drugs in DayQuil.

In fact, some studies show that combining ibuprofen and acetaminophen (the pain reliever in DayQuil) can be more effective in treating pain and reducing fever than either alone. You can even get acetaminophen and ibuprofen in combination with one another (e.g., Advil Dual Action).

Final Words

Thanks for your great question and reach back out anytime!


  • Acetaminophen Monograph, PubChem
  • Dextromethorphan Monograph, PubChem
  • Ibuprofen Monograph, PubChem
  • Phenylephrine Monograph, PubChem
  • Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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