Can You Take Doxycycline With NyQuil?
In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between NyQuil and doxycycline.
I was put on doxycycline for an infection I have. Is it safe to take NyQuil at night?
Dec 15, 2022- Doxycycline is safe to take with all NyQuil products including NyQuil, NyQuil Severe, and NyQuil Cough DM, as there are no known interactions between them.
- NyQuil works well with doxycycline to help relieve cold and cough symptoms while you're taking the antibiotic.
Answer
Thanks for reaching out to us! Doxycycline is perfectly safe to take with NyQuil. There is no known interaction between them.
This applies to all the different NyQuil products, which include:
- NyQuil
- NyQuil Severe
- NyQuil Cough DM + Congestion
- NyQuil VapoCool
These NyQuil products are all safe to take with doxycycline and represent a good over-the-counter cough/cold medication to help relieve some of the symptoms you may be experiencing.
NyQuil Products With Doxycycline
All NyQuil products contain a combination of medications. For example, 'original' NyQuil contains:
- Acetaminophen
- Dextromethorphan
- Doxylamine
Acetaminophen is an analgesic and fever reducer. It is the active ingredient in 'Tylenol'.
Dextromethorphan is a cough suppressant and helps to reduce the frequency and severity of coughing.
Doxylamine is a sedating antihistamine, similar to Benadryl (diphenhydramine). It can help to dry up mucus and post-nasal drip, while also helping you sleep due to its sedative effect.
A similar product, NyQuil 'Severe' adds on the nasal decongestant phenylephrine.
As mentioned, there are no known interactions between NyQuil products and doxycycline. In fact, NyQuil is safe to take with most antibiotics.
If you have any other questions about NyQuil and a specific antibiotic, let us know! We'll be happy to answer.
Final Words
Thanks for reaching out! Contact us again anytime.
Glossary — Terms in This Answer
- Doxycycline
- An antibiotic medication used to treat bacterial infections.
- Analgesic
- A medication that relieves pain.
- Acetaminophen
- A common pain reliever and fever-reducing medication also known as Tylenol.
- Dextromethorphan
- A cough suppressant that reduces the urge and frequency of coughing.
- Antihistamine
- A medication that blocks histamine to reduce allergy symptoms and help dry up mucus.
- Doxylamine
- A sedating antihistamine that helps dry mucus and promotes sleep.
- Decongestant
- A medication that reduces nasal congestion and swelling in the sinuses.
- Phenylephrine
- A nasal decongestant that helps relieve congestion by narrowing blood vessels in the nose.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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