Can You Take Doxycycline With NyQuil?

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between NyQuil and doxycycline.

Question

I was put on doxycycline for an infection I have. It is safe to take NyQuil at night?

Asked by Luna On Dec 15, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Dec 15, 2022
Last updated Apr 30, 2024

Key points

  • There is no known interaction between NyQuil and doxycycline.

Answer

Thanks for reaching out to us! Doxycycline is perfectly safe to take with NyQuil. There is no known interaction between them.

This applies to all the different NyQuil products, which include:

  • NyQuil
  • NyQuil Severe
  • NyQuil Cough DM + Congestion
  • NyQuil VapoCool

These NyQuil products are all safe to take with doxycycline and represent a good over-the-counter cough/cold medication to help relieve some of the symptoms you may be experiencing.

NyQuil Products With Doxycycline

All NyQuil products contain a combination of medications. For example, 'original' NyQuil contains:

  • Acetaminophen
  • Dextromethorphan
  • Doxylamine

Acetaminophen is an analgesic and fever reducer. It is the active ingredient in 'Tylenol'.

Dextromethorphan is a cough suppressant and helps to reduce the frequency and severity of coughing.

Doxylamine is a sedating antihistamine, similar to Benadryl (diphenhydramine). It can help to dry up mucus and post-nasal drip, while also helping you sleep due to its sedative effect.

A similar product, NyQuil 'Severe' adds on the nasal decongestant phenylephrine.

As mentioned, there are no known interactions between NyQuil products and doxycycline. In fact, NyQuil is safe to take with most antibiotics.

If you have any other questions about NyQuil and a specific antibiotic, let us know! We'll be happy to answer.

Final Words

Thanks for reaching out! Contact us again anytime.

References

  • NyQuil Manufacturer Website, Vicks
  • Doxycycline Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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