Can You Take NyQuil With Robitussin?

In our latest question and answer, the pharmacist discusses whether or not NyQuil can be taken with Robitussin.


Can you take Nyquil and Robitussin together?

Asked by Ria On Aug 17, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 17, 2022
Last updated Jul 18, 2024

Key points

  • Many NyQuil and Robitussin products contain the same drugs (e.g. dextromethorphan) and it is important not to double up on the same drug and take too much.
  • Always look at the labels of the products you are looking to use to ensure they don't contain the same ingredients.


In most cases, NyQuil should not be taken with Robitussin products as they share many of the same ingredients. Both Robitussin and NyQuil are brand names and there are a variety of products marketed under each. it is important to look at the label of the products to double-check whether or not they contain the same ingredients. You don't want to double up on the same drug.

Most Robitussin and NyQuil products contain dextromethorphan, a cough suppressant, and that is typically the drug to be concerned about getting too much of when taking multiple products.

NyQuil Ingredients

NyQuil contains the following ingredients:

  • Acetaminophen 650 mg (Pain reliever/fever reducer)
  • Dextromethorphan HBr 30 mg (Cough suppressant)
  • Doxylamine succinate 12.5 mg (Antihistamine)

Ingredients In Robitussin Products

As mentioned, there are a variety of Robitussin products on the market, and ingredients differ depending on the product. "Original" Robitussin contains only dextromethorphan, a cough suppressant. As NyQuil already contains dextromethorphan, they should not be used together.

Below, is a list of ingredients in the most common Robitussin products on the market:

Robitussin Cough & Chest Congestion DM

  • Dextromethorphan (cough suppressant)
  • Guaifenesin (expectorant)

Robitussin Night Time Cough DM

  • Dextromethorphan (cough suppressant)
  • Doxylamine (sedating antihistamine)

Robitussin 12-Hour Cough Relief

  • Dextromethorphan (cough suppressant)

Robitussin Severe Multi-Symptom Cough Cold & Flu

  • Acetaminophen (analgesic)
  • Dextromethorphan (cough suppressant)
  • Guaifenesin (expectorant)
  • Phenylephrine (nasal decongestant)

Robitussin Severe Multi-Symptom Cough Cold & Flu Nighttime

  • Acetaminophen (analgesic)
  • Diphenhydramine (sedating antihistamine)
  • Phenylephrine (nasal decongestant)

Robitussin Multi-Symptom Cold CF

  • Dextromethorphan (cough suppressant)
  • Guaifenesin (expectorant)
  • Phenylephrine (nasal decongestant)

Final Words

As evidenced above, most Robitussin products contain some of the same ingredients that NyQuil contains, and therefore they should not be dosed together. You certainly can find some Robitussin products that don't share any ingredients with NyQuil, and they would be fine to take. Just look at those labels!


  • Dextromethorphan Monongraph, PubChem
  • NyQuil Manufacturer Website, Vicks
  • Robitussin Manufacturer Website, Robitussin

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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