Can You Use Oral And Nasal Antihistamines Together?

In our latest question and answer, the pharmacist discusses whether or not oral and nasal antihistamines can be used together.


Can you take and antihistamine like Zyrtec D with a antihistamine nasal spray such as Olopatadine HCI?

Asked by Ash On Aug 07, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 07, 2022
Last updated Aug 07, 2022

Key points

  • In general, it is safe to combine oral antihistamines (like Zyrtec) and nasal antihistamines (like Astelin).
  • However, most studies find that the combination of oral and nasal antihistamines isn't more effective than using a nasal antihistamine alone.


Yes, oral antihistamines can be used in conjunction with nasal antihistamines, although current data suggests that the combination of the two is no more effective than using a nasal antihistamine as the sole treatment.

Below, we discuss the data available in regard to whether or not there is benefit in combining an oral antihistamine such as Zyrtec with a nasal antihistamine such as Patanase.

Oral Antihistamines For Allergies

Second-generation antihistamines are the most commonly used medications for the treatment and prevention of allergy symptoms. They are preferable over the first-generation antihistamines as they generally last about 24 hours per dose and, with the exception of Zyrtec, are non-drowsy. The available over-the-counter second-generation antihistamines include:

  • Claritin (loratadine)
  • Zyrtec (cetirizine)
  • Allegra (fexofenadine)
  • Xyzal (levocetirizine)

All of the above agents are comparable in terms of their efficacy and no one agent is typically recommended over another. However, Xyzal (levocetirizine) may be the most beneficial for allergic reactions manifested on the skin.

Nasal Antihistamines

A relatively new class of medications, nasal antihistamine products include:

  • Astelin/Astepro (azelastine)
  • Patanase (Olopatadine)

The nasal antihistamines have a similar mechanism of action as the oral antihistamines in that they are H1 (histamine receptor) antagonists or blockers. The nasal spray products are not as well absorbed into the body as oral antihistamines and they exert a more potent "local" effect in the nasal passages than oral products.

Studies have found that nasal antihistamines may be more effective for treating allergic rhinitis (i.e. inflammation of the nasal passages) than oral antihistamines. This is most likely due to nasal antihistamines preventing the release of histamine from mast cells and their pronounced local effect.

Use Of Oral & Nasal Antihistamines Together

While oral and nasal antihistamines are both histamine receptor blockers, multiple studies have evaluated their combined use in the treatment of allergic symptoms. 

In one study, it was found that the combined use of Allegra (fexofenadine) and Astelin (azelastine) were well tolerated and effective. However, the study also found that the use of Astelin was just as effective as the combination of Astelin and Allegra.

Another study found the combined use Astelin and Claritin were effective and well tolerated in individuals for the treatment of allergic rhinitis symptoms and were more effective than Claritin alone. Similar to the above-cited study, it doesn't appear that using both Astelin and Claritin is more effective than using Astelin alone.

So, while studies have found that it is safe and effective to use a combination of an oral antihistamine (e.g. Zyrtec) and a nasal antihistamine (e.g. Patanase), there is some uncertainty if the use of both drugs is more effective than using a nasal antihistamine alone.

Final Words

Thanks for reaching out to us! 


  • Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine, ScienceDirect
  • Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine, ScienceDirect

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