Is Creatine Safe To Take With Meloxicam Or Other NSAIDs?

In our latest question and answer, the pharmacist discusses the safety of combining an NSAID like meloxicam and creatine.


Can creatine be taken while using a meloxicam prescription?

Asked by Ray On Aug 15, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 15, 2023
Last updated Jul 23, 2024

Key points

  • There is no known interaction between creatine and meloxicam but caution is advised due to potential kidney-related issues associated with long-term meloxicam use and infrequent reports of kidney problems linked to creatine usage.
Creatine and Meloxicam Interaction

Quick Answer

There is no strong evidence to suggest an interaction between creatine and meloxicam. While some concerns exist about the potential impact of long-term use of NSAIDs like meloxicam on kidney function, and there have been rare reports of kidney problems associated with creatine use, the overall risk of adverse effects appears to be low when meloxicam and creatine are taken together.

Detailed Answer

Creatine is a naturally occurring compound commonly used as a dietary supplement to enhance athletic performance and support muscle growth. It works by increasing the availability of adenosine triphosphate (ATP), the primary energy currency of cells, particularly during short bursts of high-intensity physical activity. Creatine is produced in the liver and kidneys and is stored in muscles.

Meloxicam, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) used to alleviate pain, inflammation, and fever. It functions by inhibiting enzymes responsible for producing prostaglandins, which are involved in inflammation and pain signaling. Meloxicam, like other NSAIDs, is primarily metabolized in the liver and excreted through the kidneys.

At present, no clinical evidence suggests a direct interaction between creatine and meloxicam.

Creatine is absorbed in the intestines and metabolized in the liver, and there is no substantial indication that it significantly interferes with the processing or elimination of meloxicam through the kidneys. There doesn't appear to be an increased risk of side effects with the combination either.

Kidney Concerns

Addressing kidney health with both creatine and meloxicam is important.

NSAIDs, including meloxicam, have been associated with potential kidney-related adverse effects, particularly when used long-term or in higher doses. These effects can include reduced blood flow to the kidneys, electrolyte imbalances, and even acute kidney injury, especially in susceptible individuals.

Creatine use has also been a subject of concern due to rare reports of kidney problems, although most studies have not found significant adverse effects in healthy individuals using recommended dosages. There does seem to be some risk, however, in instances where individuals have preexisting kidney conditions, and they may be more vulnerable to potential issues.

Overall, most studies evaluating the long-term safety of creatine note that it doesn't appear to affect kidney health. One such study concluded:

We believe that medium-term oral creatine supplements do not affect kidney function in healthy individuals.
The Lancet VOLUME 352, ISSUE 9123, P234, JULY 18, 1998

As a precaution, consulting a healthcare professional, such as your physician or pharmacist, is advisable before combining creatine and meloxicam, however. This is especially important for individuals with a history of kidney problems, as they may be at a higher risk of adverse effects.

Final Words

In conclusion, while current evidence does not strongly suggest a direct interaction between creatine and meloxicam, it's prudent to be cautious when combining these them, especially if you have kidney health concerns.


  • Renal dysfunction accompanying oral creatine supplements, The Lancet
  • Dietary creatine supplementation does not aVect some haematological indices, or indices of muscle damage and hepatic and renal function, BMJ

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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