Is Elderberry Safe To Take With Lipitor?

In our latest question and answer, the pharmacist discusses whether or not Lipitor is safe to take with elderberry supplements.

3 min read Updated Jun 2026 2,387 views
Is Elderberry Safe To Take With Lipitor?
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Kat asked

I take Lipitor and recently came down with something. I have an over-the-counter supplement that has elderberry in it. Is it safe to take it with the Lipitor?

Jul 07, 2022
The quick answer
  • Elderberry and Lipitor are considered safe to take together with no known interactions between them. Elderberry is generally recognized as safe by the FDA and is one of the more well-researched supplements. You should avoid combining elderberry with medications that suppress the immune system.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
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Hello and thanks for reaching out to us! It's always a good idea to ask about potential drug interactions between your prescription medications and over-the-counter supplements. We're here to help!

Based on what we know about how elderberry works and how our body metabolizes it, there are no known or expected interactions between it and Lipitor (atorvastatin). They are considered safe to take together. I could find no information suggesting that they interfere with one another in any way.

It is always a challenge to definitively say there are no interactions between prescription drugs and dietary supplements due to the lack of large-scale published studies, but elderberry in particular is one of the more well-researched ones. You can feel safe supplementing with elderberry to help with your symptoms.

What Is Elderberry?

Elderberry has a long history of use medically for its purported immune system enhancing effects. It is mostly marketed in over-the-counter supplements to help shorten the duration of colds and the flu. Although there have been relatively few studies testing how well it works in this regard, some small clinical studies have shown it can affect different components of the immune system (e.g. cytokines) and may have positive benefits in healthy adults and children. Other studies have shown no benefit, however. More rigorous studies are needed to better understand exactly the benefits it can have as a supplement.

Regardless, elderberry seems relatively safe to use in amounts that would commonly be found in food. In fact, it is 'generally recognized as safe' (GRAS) by the FDA.

There are no known drug interactions between elderberry and prescription or over-the-counter medications. Based on studies showing that it may have immunostimulating effects, it theoretically could interact with immunosuppressants, but this has not been shown clinically. Regardless, simply due to the lack of studies, it should not be combined with drugs that are supposed to suppress the immune system.

What Is Lipitor?

Lipitor (atorvastatin) is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. It is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood.

Lipitor is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Final Words

Thanks again for reaching out to us!

References & sources
  1. Atorvastatin Monograph — PubChem
  2. Lipitor Prescribing Information — AccessFDA
  3. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial — PubMed
  4. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials — PubMed
Glossary — Terms in This Answer
Drug interactions
When two or more medications affect how each other works in your body, potentially causing unwanted effects or reducing effectiveness.
Metabolizes
The process by which your body breaks down and processes substances like food, supplements, and medications.
Cytokines
Signaling molecules produced by immune cells that help coordinate the immune system's response to infections and threats.
GRAS
An FDA designation meaning a substance is 'generally recognized as safe' for use in food and supplements based on scientific evidence.
Immunosuppressants
Medications that reduce or suppress the activity of the immune system.
HMG-CoA reductase inhibitors
A class of medications also known as statins that work by blocking an enzyme involved in cholesterol production.
LDL cholesterol
Low-density lipoprotein cholesterol, often called 'bad cholesterol' because it can build up in arteries and increase heart disease risk.
Triglycerides
A type of fat found in your blood that, when elevated, can increase the risk of heart disease.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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