Is It Safe To Take Zyrtec (Cetirizine) With Magnesium Supplements?

In our latest question and answer, the pharmacist discusses the combined use of cetirizine and magnesium supplements.

1 min read Updated Jun 2026 2,605 views
Is It Safe To Take Zyrtec (Cetirizine) With Magnesium Supplements?
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pete asked

Are there any interaction problems between cetirizine and magnesium supplements?

Jun 17, 2024
The quick answer
  • Zyrtec and magnesium supplements have no known interaction and are safe to take together. If your magnesium supplement contains other ingredients besides magnesium, check those ingredients for potential interactions with Zyrtec.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks for reaching out and great question!

Magnesium does interact with many different drugs, and we have quite a few interactions listed for magnesium in our drug-herbal interaction checker.

Most interactions with magnesium involve it reducing the absorption of other drugs (such as this interaction we have listed with ciprofloxacin), but it can interact with drugs via other mechanisms as well.

Fortunately, there is no known interaction between magnesium and Zyrtec (cetirizine). They are considered safe to take together. We discuss the combination of cetirizine and magnesium further on its own detail page (Magnesium - Cetirizine Interaction Details | HelloPharmacist).

I do want to point out that this answer is regarding magnesium supplements that only contain magnesium. If the supplement in question contains more ingredients than just magnesium, please be sure to consider those as well.

Final Words

Thanks for reaching out! Please feel free to contact us again only contain

Glossary — Terms in This Answer
Absorption
The process by which a drug enters the bloodstream and becomes available in the body.
Ciprofloxacin
An antibiotic medication used to treat bacterial infections.
Cetirizine
An antihistamine drug used to relieve allergy symptoms like itching and sneezing.
Interaction
When two substances affect how each other works in the body.
Supplements
Products taken by mouth containing vitamins, minerals, or other ingredients intended to supplement the diet.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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