Taking Mucinex DM With Tylenol Cold And Head Congestion
In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Mucinex DM and Tylenol Cold And Head Congestion

Question
Can I take Mucinex DM, Benadryl, and 'Tylenol Cold and Head Congestion' together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 02, 2025
Key points
- Mucinex DM and 'Tylenol Cold and Head Congestion' both contain guaifenesin, so should not be taken together.
- Always read the labels of the over-the-counter products you are considering taking as many contain the same ingredients. It is important not to double-up on any particular drug.
Answer
Mucinex DM should not be taken at the same time as 'Tylenol Cold And Head Congestion' as they both contain guaifenesin. Taking both medications together is a therapeutic duplication and could potentially increase the risk of side effects.
It is important to always read the labels of the drugs you are looking to take, especially over-the-counter cold/flu medications, as they often contain similar ingredients.
Tylenol Cold And Head Congestion Ingredients
'Tylenol Cold And Head Congestion' contains the following active ingredients:
- Acetaminophen
- Phenylephrine
- Guaifenesin
Acetaminophen is a pain reliever and the active ingredient in Tylenol.
Phenylephrine is a nasal decongestant and active ingredient in Sudafed PE.
Guaifenesin is an expectorant and the active ingredient in Mucinex.
***Please note that since the first publication of this answer, Tylenol has changed the name of this product to 'Tylenol Sinus Severe'.***
Mucinex DM Ingredients
Mucinex DM contains the following active ingredients:
- Dextromethorphan
- Guaifenesin
Dextromethorphan is a cough suppressant.
As you can see, Mucinex DM and 'Tylenol Cold and Head Congestion' both contain guaifenesin.
Taking Mucinex DM With Tylenol Cold And Head Congestion
Since both of these medications contain guaifenesin, they should not be used together. It is important to always look at the labels of over-the-counter medications as they often contain more than one active ingredient.
If you are looking for cough relief, dextromethorphan is available as a single ingredient in products such as Delsym.
Final Words
You mentioned Benadryl in your question too. That is safe to take with all the drugs in question here (Mucinex DM and 'Tylenol Cold and Head Congestion').
I appreciate you reaching out to us!
If I could leave you with a final thought, it is that you should always read the labels of the drugs you are taking. This is especially true with over-the-counter medications.
Many products share a brand name (e.g., Tylenol, Mucinex, DayQuil, etc...) but can contain several different ingredients.
You want to be sure not to take two products that contain the same drug.
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Dr. Brian Staiger, PharmD
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