Taking Mucinex DM With Tylenol Cold And Head Congestion

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Mucinex DM and Tylenol Cold And Head Congestion

Question

Can I take Mucinex DM, Benadryl, and 'Tylenol Cold and Head Congestion' together?

Asked by Ashley On Nov 17, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 17, 2022
Last updated Apr 28, 2024

Key points

  • Mucinex DM and 'Tylenol Cold and Head Congestion' both contain guaifenesin, so should not be taken together.
  • Always read the labels of the over-the-counter products you are considering taking as many contain the same ingredients. It is important not to double-up on any particular drug.

Answer

Mucinex DM should not be taken at the same time as 'Tylenol Cold And Head Congestion' as they both contain guaifenesin. Taking both medications together is a therapeutic duplication and could potentially increase the risk of side effects.

It is important to always read the labels of the drugs you are looking to take, especially over-the-counter cold/flu medications, as they often contain similar ingredients.

Tylenol Cold And Head Congestion Ingredients

'Tylenol Cold And Head Congestion' contains the following active ingredients:

  • Acetaminophen
  • Phenylephrine
  • Guaifenesin

Acetaminophen is a pain reliever and the active ingredient in Tylenol.

Phenylephrine is a nasal decongestant and active ingredient in Sudafed PE.

Guaifenesin is an expectorant and the active ingredient in Mucinex. 

***Please note that since the first publication of this answer, Tylenol has changed the name of this product to 'Tylenol Sinus Severe'.***

Mucinex DM Ingredients

Mucinex DM contains the following active ingredients:

  • Dextromethorphan
  • Guaifenesin

Dextromethorphan is a cough suppressant.

As you can see, Mucinex DM and 'Tylenol Cold and Head Congestion' both contain guaifenesin.

Taking Mucinex DM With Tylenol Cold And Head Congestion

Since both of these medications contain guaifenesin, they should not be used together. It is important to always look at the labels of over-the-counter medications as they often contain more than one active ingredient.

If you are looking for cough relief, dextromethorphan is available as a single ingredient in products such as Delsym.

Final Words

You mentioned Benadryl in your question too. That is safe to take with all the drugs in question here (Mucinex DM and 'Tylenol Cold and Head Congestion').

I appreciate you reaching out to us!

If I could leave you with a final thought, it is that you should always read the labels of the drugs you are taking. This is especially true with over-the-counter medications.

Many products share a brand name (e.g., Tylenol, Mucinex, DayQuil, etc...) but can contain several different ingredients.

You want to be sure not to take two products that contain the same drug.

References

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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