Vyvanse Interaction With Several Supplements
In our latest question and answer, the pharmacist discusses interaction concerns between Vyvanse and several OTC supplements.
I take Elvanse 40mg for ADHD treatment. I usually take it in the morning with blackcurrant Robinson's Cordial, along with my breakfast (Weetabix chocolate chunk cereal and whole milk with yogurt). I also take my supplements at the same time: a multivitamin, fish oil capsule, cholecalciferol 2000 IU, and probiotic capsule. I tend to take these supplements on weekdays only. Would any of these interact with my Elvanse's absorption, or am I able to take these all together in the morning?
Apr 01, 2024- None of the supplements you mentioned (black currant, fish oil, cholecalciferol, multivitamin, yogurt, or probiotic capsule) are known to interact with Vyvanse. Yogurt is slightly acidic and theoretically could reduce Vyvanse effectiveness over time if consumed in large amounts, but this is unlikely with normal consumption. Vyvanse can be taken with or without food since its absorption isn't significantly affected by stomach pH.
Answer
Thanks for your question! Since I am in the United States, I will be referencing Elvanse as 'Vyvanse,' which is the brand name here in the States. Both drugs contain the same active ingredient, lisdexamfetamine.
You mentioned a number of different supplements, all of which I have taken into consideration:
- Black Currant
- 'Yogurt'
- Multivitamin
- Fish oil
- Cholecalciferol
- Probiotic capsule
None of these are known to interact with Vyvanse. Some of them certainly do have interactions that are important to know about (such as black currant and fish oil with anticoagulants), but again, there is no known interaction between anything in the above list and Vyvanse:
We don't have specific pages for 'multivitamins, yogurt or probiotic capsules', but there are no known problems between Vyvanse and any of those.
I will say, however, that the urinary elimination of amphetamines (like Vyvanse) can be affected by drugs or food that acidify or alkalinize the urine. Acidification of the urine speeds amphetamine elimination (which may reduce effectiveness).
Yogurt is slightly acidic, so, theoretically, if you ate a lot of it consistently, it may over time slightly reduce the effectiveness of Vyvanse due to acidification of urine. I really wouldn't expect this to happen with normal consumption though.
Additionally, the absorption of Vyvanse isn't known to be significantly affected by stomach pH, which is why the drug can be taken with or without food.
Final Words
Based on the information I have available, I don't see any interactions with what you listed.
Thanks for connecting with us! I hope this was helpful.
References & sources
Glossary — Terms in This Answer
- Lisdexamfetamine
- The active pharmaceutical ingredient in Vyvanse that treats attention and focus problems.
- Vyvanse
- The brand name for a prescription medication used in the United States containing lisdexamfetamine.
- Cholecalciferol
- Vitamin D, a nutrient the body uses to support bone health and immune function.
- Probiotic
- A supplement containing beneficial bacteria intended to support digestive and gut health.
- Anticoagulants
- Medications that help prevent blood clots by reducing the blood's ability to clot.
- Urinary elimination
- The process by which the kidneys remove drugs or substances from the body through urine.
- Acidify
- To make something more acidic, which can affect how quickly certain drugs are removed from the body.
- Stomach pH
- A measure of acidity or alkalinity in the stomach that can affect how medications are absorbed into the bloodstream.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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