Acecainide

23 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Ofloxacin Otic Arsenic Trioxide Ofloxacin Lacosamide Injection Chloroquine

23 Major

All (23) Major (23)

Major

Acecainide Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Buprenorphine Belbuca Explained Increased risk of QT prolongation Details Acecainide Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Arsenic Trioxide Injection Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Acecainide Chloroquine Aralen® Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Acecainide Dofetilide Tikosyn An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Acecainide Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Acecainide Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Acecainide Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Acecainide Levofloxacin Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Levofloxacin Injection Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Ofloxacin Floxin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Acecainide Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.