Acetaminophen Rectal

Name: Acetaminophen Rectal Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

28 interactions 489 cited references

Also sold as: Acephen Acephen Rectal Suppository® Feverall Feverall Rectal Suppository® Neopap Supprettes Rectal Suppository® Tylenol Rectal Suppository®

About Acetaminophen Rectal

Acetaminophen rectal is used to relieve mild to moderate pain from headaches or muscle aches and to reduce a fever. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Read the full Acetaminophen Rectal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid

10 Major 13 Moderate 5 Minor

All (28) Major (10) Moderate (13) Minor (5)

Major

Acetaminophen Rectal Articaine An increased risk of methemoglobinemia Details Acetaminophen Rectal Carbamazepine Carbatrol An increased risk of acetaminophen hepatotoxicity and reduced acetaminophen exposure Details Acetaminophen Rectal Exenatide Bydureon Reduced oral acetaminophen absorption and reduced efficacy of oral acetaminophen Details Acetaminophen Rectal Flucloxacillin An increased risk of high anion gap metabolic acidosis (HAGMA) Details Acetaminophen Rectal Imatinib Gleevec Increased acetaminophen levels Details Acetaminophen Rectal Isoniazid An increased risk of hepatotoxicity Details Acetaminophen Rectal Lidocaine Akten An increased risk of methemoglobinemia Details Acetaminophen Rectal Pixantrone Increased CYP1A2 substrate exposure Details Acetaminophen Rectal Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate An inadequate immunologic response to the vaccine Details Acetaminophen Rectal Probenecid Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.