Acetaminophen Rectal

28 interactions 489 cited references
Also sold as: Acephen Acephen Rectal Suppository® Feverall Feverall Rectal Suppository® Neopap Supprettes Rectal Suppository® Tylenol Rectal Suppository®
About Acetaminophen Rectal

Acetaminophen rectal is used to relieve mild to moderate pain from headaches or muscle aches and to reduce a fever. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Read the full Acetaminophen Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid
10 Major 13 Moderate 5 Minor
All (28) Major (10) Moderate (13) Minor (5)

Major

Acetaminophen Rectal Articaine An increased risk of methemoglobinemia Details Acetaminophen Rectal Carbamazepine Carbatrol An increased risk of acetaminophen hepatotoxicity and reduced acetaminophen exposure Details Acetaminophen Rectal Exenatide Bydureon Reduced oral acetaminophen absorption and reduced efficacy of oral acetaminophen Details Acetaminophen Rectal Flucloxacillin An increased risk of high anion gap metabolic acidosis (HAGMA) Details Acetaminophen Rectal Imatinib Gleevec Increased acetaminophen levels Details Acetaminophen Rectal Isoniazid An increased risk of hepatotoxicity Details Acetaminophen Rectal Lidocaine Akten An increased risk of methemoglobinemia Details Acetaminophen Rectal Pixantrone Increased CYP1A2 substrate exposure Details Acetaminophen Rectal Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate An inadequate immunologic response to the vaccine Details Acetaminophen Rectal Probenecid Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details

Moderate

Acetaminophen Rectal Acenocoumarol Potentiation of anticoagulant effect Details Acetaminophen Rectal Busulfan Busulfex Reduced busulfan clearance Details Acetaminophen Rectal Diflunisal Dolobid An increased risk of acetaminophen toxicity (hepatotoxicity) Details Acetaminophen Rectal Ethinyl Estradiol Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Rectal Fosphenytoin Cerebyx Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Rectal Lixisenatide Slowed absorption of acetaminophen Details Acetaminophen Rectal Norethindrone Aygestin Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Rectal Norgestimate Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Rectal Phenytoin Dilantin Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Rectal Piperaquine Reduced exposure of CYP2E1 substrates Details Acetaminophen Rectal Sulfinpyrazone Increased hepatotoxicity in acetaminophen overdose Details Acetaminophen Rectal Warfarin Coumadin An increased risk of bleeding Details Acetaminophen Rectal Zidovudine Retrovir Neutropenia; acetaminophen toxicity (hepatotoxicity) Details

Minor

Acetaminophen Rectal Chloramphenicol Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Rectal Cholestyramine Prevalite Decreased acetaminophen effectiveness Details Acetaminophen Rectal Fenoldopam Increased fenoldopam concentration Details Acetaminophen Rectal Lamotrigine Lamictal Decreased lamotrigine effectiveness Details Acetaminophen Rectal Metyrapone Metopirone An increased risk of acetaminophen toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.