Acetazolamide

Name: Acetazolamide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

46 interactions 434 cited references

Also sold as: Diamox® Sequels®

About Acetazolamide

Acetazolamide is a diuretic medication used to treat glaucoma, altitude sickness, fluid retention, and certain types of epilepsy. Read the full Acetazolamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methenamine Amphetamine Arsenic Trioxide Methotrexate Injection Lithium Carbonate Aspirin Rectal

1 Contraindicated 36 Major 9 Moderate

All (46) Contraindicated (1) Major (36) Moderate (9)

Moderate

Acetazolamide Fosphenytoin Cerebyx An increased risk of osteomalacia Details Acetazolamide Licorice Increased risk of hypokalemia and/or reduced effectiveness of the diuretic Details Acetazolamide Phenytoin Dilantin An increased risk of osteomalacia Details Acetazolamide Salsalate Disalcid Metabolic acidosis and CNS toxicity (lethargy, confusion, urinary incontinence) Details Acetazolamide Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity Details Acetazolamide Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.