Afatinib

54 interactions 114 cited references

Also sold as: Gilotrif Gilotrif®

About Afatinib

Afatinib is used to treat certain types of non-small cell lung cancer that has spread to nearby tissues or to other parts of the body. Afatinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multip… Read the full Afatinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Varicella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Yellow Fever Vaccine

9 Contraindicated 41 Major 4 Moderate

All (54) Contraindicated (9) Major (41) Moderate (4)

Contraindicated

Afatinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Afatinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Afatinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Afatinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Afatinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Afatinib Amiodarone Nexterone Increased exposure of afatinib Details Afatinib Apalutamide Erleada Decreased afatinib exposure Details Afatinib Berotralstat Orladeyo Increased P-gp substrate exposure Details Afatinib Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Afatinib Carbamazepine Carbatrol Decreased afatinib exposure Details Afatinib Carvedilol Coreg Increased exposure of afatinib Details Afatinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Afatinib Clarithromycin Biaxin Increased exposure of afatinib Details Afatinib Cobicistat Tybost Increased exposure of afatinib Details Afatinib Conivaptan Vaprisol Increased exposure of afatinib Details Afatinib Cyclosporine Atopica Increased exposure of afatinib Details Afatinib Dronedarone Multaq Increased exposure of afatinib Details Afatinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Ensitrelvir Increased risk of P-gp substrate exposure Details Afatinib Erythromycin Erythrocin Stearate Increased exposure of afatinib Details Afatinib Flibanserin Addyi Increased exposure of afatinib Details Afatinib Fosphenytoin Cerebyx Decreased afatinib exposure Details Afatinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib Itraconazole Sporanox Increased exposure of afatinib Details Afatinib Ketoconazole Extina Increased exposure of afatinib Details Afatinib Lapatinib Tykerb Increased exposure of afatinib Details Afatinib Lenacapavir Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Afatinib Phenytoin Dilantin Decreased afatinib exposure Details Afatinib Quinidine Cardioquin® Increased exposure of afatinib Details Afatinib Ranolazine Aspruzyo Increased exposure of afatinib Details Afatinib Rifampin Rifadin Decreased afatinib exposure Details Afatinib Ritonavir Norvir Increased exposure of afatinib Details Afatinib Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Afatinib St John's Wort Decreased afatinib exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.