Allopurinol Injection

26 interactions 333 cited references
Also sold as: Aloprim Aloprim® Zyloprim
About Allopurinol Injection

Allopurinol injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications who cannot take oral allopurinol. Allopurinol is in a class of medications called xanthine oxi… Read the full Allopurinol Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Didanosine Fezolinetant Acenocoumarol Azathioprine Capecitabine Captopril
2 Contraindicated 18 Major 5 Moderate 1 Minor
All (26) Contraindicated (2) Major (18) Moderate (5) Minor (1)

Contraindicated

Allopurinol Injection Didanosine Videx® Increased serum concentrations of didanosine Details Allopurinol Injection Fezolinetant Increased fezolinetant exposure Details

Major

Allopurinol Injection Acenocoumarol Increased INR Details Allopurinol Injection Azathioprine Azasan An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Allopurinol Injection Capecitabine Xeloda Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Allopurinol Injection Captopril Capoten® Hypersensitivity reactions (Stevens-Johnson syndrome, skin eruptions) Details Allopurinol Injection Clomipramine Anafranil Increased clomiPRAMINE exposure Details Allopurinol Injection Doxifluridine Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Allopurinol Injection Enalapril Epaned Hypersensitivity reactions (Stevens-Johnson syndrome, skin eruptions, anaphylactic coronary spasm) Details Allopurinol Injection Enalaprilat Hypersensitivity reactions (Stevens-Johnson syndrome, skin eruptions, anaphylactic coronary spasm) Details Allopurinol Injection Fluorouracil Adrucil Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Allopurinol Injection Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Allopurinol Injection Mercaptopurine Purinethol® An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Allopurinol Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Allopurinol Injection Pegloticase Increased risk of anaphylaxis and infusion reactions Details Allopurinol Injection Phenprocoumon Increased INR Details Allopurinol Injection Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Allopurinol Injection Tegafur Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Allopurinol Injection Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Allopurinol Injection Warfarin Coumadin Increased INR Details

Moderate

Allopurinol Injection Aluminum Hydroxide AlternaGEL® Decreased allopurinol effectiveness Details Allopurinol Injection Anisindione An increased risk of bleeding Details Allopurinol Injection Cyclosporine Atopica Increased cycloSPORINE exposure Details Allopurinol Injection Theophylline Accurbron® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Allopurinol Injection Vidarabine Neurotoxicity, tremors, impaired cognitive function Details

Minor

Allopurinol Injection Probenecid An increase in probenecid concentration Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.