Almotriptan

22 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Nasal Spray Methylergonovine Dihydroergotamine Injection Acetaminophen And Codeine Palonosetron Injection Granisetron Transdermal Patch
3 Contraindicated 18 Major 1 Moderate
All (22) Contraindicated (3) Major (18) Moderate (1)

Contraindicated

Almotriptan Dihydroergotamine Injection DHE-45® Injection Increased risk of coronary artery vasospasm Details Almotriptan Dihydroergotamine Nasal Spray Migranal Increased risk of coronary artery vasospasm Details Almotriptan Methylergonovine Methergine Prolonged vasospastic reactions Details

Major

Almotriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Almotriptan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Almotriptan Sertraline Explained An increased risk of serotonin syndrome Details Almotriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Almotriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Almotriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Almotriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Almotriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Almotriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Almotriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Almotriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Almotriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Almotriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Almotriptan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Almotriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Almotriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Almotriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Almotriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Almotriptan Ketoconazole Topical Extina® Foam Increased almotriptan exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.