Almotriptan and Dihydroergotamine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Almotriptan
No brand names on recordDihydroergotamine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of coronary artery vasospasm
Interaction Deep Dive
Concurrent use of almotriptan and dihydroergotamine is contraindicated if used within 24 hours of each other as it may increase risk of coronary artery vasospasm1.
Why it happens (mechanism)
Additive vasoconstrictive effects
Literature reports
1 report — tap to read
a) Triptans (serotonin 5-HT1B/1D receptor agonists) have been reported to cause coronary artery vasospasm, and its effect could be additive with dihydroergotamine 1.
Common questions
Can I take Almotriptan and Dihydroergotamine Injection together?
Increased risk of coronary artery vasospasm Always confirm with your pharmacist or prescriber before making any change.
How serious is the Almotriptan and Dihydroergotamine Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Almotriptan or Dihydroergotamine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: BREKIYA® subcutaneous injection, dihydroergotamine mesylate subcutaneous injection. Amneal Specialty, a division of Amneal Pharmaceuticals LLC (per manufacturer), Bridgewater, NJ, 2025. DailyMed
Keep reading about Almotriptan
Keep reading about Dihydroergotamine Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist